Rate of Sterilization as a Factor in the Selection of Ophthalmic Solutions

Ophthalmic Pharmacology and Toxicology

“…For preparation of self-sterilizing collyria the incorporation of one of these antibiotics, polymyxin B sulfate, has been demonstrated in careful experimental work to provide more rapid and reliable results, particularly in eliminating Pseudomonas aeruginosa, than do the usual additions of benzalkonium or chlorobutanol. 93 Isoniazid, a chemotherapeutic agent which has proved valuable in treatment of pulmonary tuberculosis, has been evaluated for use in ophthalmic therapy. In rabbits this drug has been found to have low toxicity and to penetrate readily into the anterior segment from the conjunctival sac and into the posterior segment from the circulation.…”