Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL)

Ellis, Kathryn A.; Szoeke, Cassandra; Bush, Ashley I.; Darby, David; Graham, Petra L.; Lautenschlager, Nicola T.; Macaulay, S. Lance; Martins, Ralph N.; Maruff, Paul; Masters, Colin L.; McBride, Simon; Pike, Kerryn E.; Rainey-Smith, Stephanie R.; Rembach, Alan; Robertson, Joanne; Rowe, Christopher C.; Savage, Greg; Villemagne, Victor L.; Woodward, Michael; Wilson, William J.; Zhang, Ping; Ames, David

doi:10.1017/s1041610213001956

Cited by 45 publications

(44 citation statements)

References 23 publications

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“…Even in other research, there is no general consensus on when a Bonferroni adjustment should be used [25,27]. Previous cognitive studies have not made adjustments to significance levels [28][29][30][31][32][33][34][35][36][37]. The current study remained consistent with previous works.…”

Section: Discussionsupporting

confidence: 88%

Grandparenting predicts late-life cognition: Results from the Women's Healthy Ageing Project

Burn

Szoeke

2015

Maturitas

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Section: Discussionsupporting

confidence: 88%

Grandparenting predicts late-life cognition: Results from the Women's Healthy Ageing Project

Burn

Szoeke

2015

Maturitas

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“…Analysis was performed on data (N = 972) collected for the Australian Imaging, Biomarkers and Lifestyle (AIBL) study at its second time point in 2008-2009 (mean age 73.8 years; Range = 61.41-97.2) (Ellis et al, 2009;2014 Participants were grouped based on cut-off points for depressive symptoms, i.e. GDS-15 score of ࣙ5 and/or a HADS-D score of ࣙ8 (Bjelland et al, 2002;Wancata et al, 2006).…”

mentioning

confidence: 99%

Comparing the Performance of the HADS and the GDS-15 in the AIBL Study

Campbell

Bryant

Ellis

et al. 2015

Int. Psychogeriatr.

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Screening measures such as the 15-item Geriatric Depression Scale (GDS-15) (Sheikh and Yesavage, 1986) and the Hospital Anxiety and Depression Scale (HADS) (Zigmond and Snaith, 1983) are important tools in the recognition of depressive symptoms in older people. While these measures are widely used, there is evidence of specific weaknesses in some cohorts and contexts, with the GDS-15 showing limitations in the context of cognitive impairment (Gilley and Wilson, 1997), and the depression subscale of the HADS (HADS-D) losing sensitivity in the context of older participants in hospital inpatient settings (Davies et al., 1993).

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“…Evidence suggests that a decline in naming and verbal fluency might reflect an early onset of cognitive deterioration [19][20][21][22] . However, in the combined sample of 535 individuals, 19% of the participants performed the test in a language different from their native tongue.…”

Section: Discussionmentioning

confidence: 99%

Improving the Measurement of Cognitive Ability in Geriatric Patients

Lebedeva

Gallant²,

Tsai³

et al. 2015

Dement Geriatr Cogn Disord

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Background/Aims: No single tool is available in geriatric clinical settings to quantitatively measure global cognitive ability at different stages ranging from normal functioning to severe impairment. We developed an adaptive test to measure cognitive ability in geriatric populations (Geriatric Rapid Adaptive Cognitive Estimate, GRACE); however, the test failed to discriminate between high-functioning individuals. This study aimed to estimate the extent to which adding more difficult items to the GRACE would improve measurement precision in the upper range of cognitive ability. Methods: The original data used to develop the GRACE was merged with newly collected data of patients who presented at local geriatric clinics. The Rasch analysis was used to estimate the difficulty level of the newly added items and evaluate whether the psychometric properties of the GRACE were improved. Results: One newly added item (Sequencing 5) had a higher difficulty level than all of the previous items in the GRACE. The rest of the new items were located in the high difficulty range. Conclusion: The psychometric properties of our adaptive screening tool were improved, and we were able to distinguish between individuals who had higher levels of cognitive functioning.

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Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL)

Abstract: There was a high retention rate after 18 months. Rates of transition from healthy aging to MCI, and MCI to AD, were consistent with established estimates. Follow-up of this cohort over longer periods will elucidate robust predictors of future cognitive decline.

Cited by 45 publications

References 23 publications

Grandparenting predicts late-life cognition: Results from the Women's Healthy Ageing Project

Grandparenting predicts late-life cognition: Results from the Women's Healthy Ageing Project

Comparing the Performance of the HADS and the GDS-15 in the AIBL Study

Improving the Measurement of Cognitive Ability in Geriatric Patients

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