Rates of Neuropsychiatric Disorders and Gestational Age at Birth in a Danish Population

Xia, Yuntian; Xiao, Jingyuan; Yu, Yongfu; Tseng, Wan‐Ling; Lebowitz, Eli R.; DeWan, Andrew T.; Pedersen, Lars Henning; Olsen, Jørn; Li, Jiong; Liew, Zeyan

doi:10.1001/jamanetworkopen.2021.14913

Cited by 16 publications

(16 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous register-based studies have reported inconsistent findings between preterm birth, poor foetal growth and anxiety disorders, both in children and adults. [5][6][7][8][13][14][15] The inconsistencies could be explained by the differences in the study designs as well by the limitations of the studies. The age ranges varied from young children to older adults and the outcome diagnoses and exposures varied substantially.…”

Section: Discussionmentioning

confidence: 99%

“…Paternal confounders were poorly taken into account, as paternal age and psychopathology only included in one study each. 7,8 Most of all, none of the previous studies examined the impact that comorbidities had on the associations between GA, WGA and anxiety disorders. Including possible comorbidities in the analyses was of major importance, as preterm birth and poor foetal…”

Section: Discussionmentioning

confidence: 99%

“…14 The other five register studies focused on mixed age groups and broader diagnostic outcomes and also produced contradictory results. [5][6][7][8]15 No significant associations have been observed between SGA and anxiety disorders just among children and adolescents. 13,14,16 However, three of the register studies that included adults found associations between being born SGA and anxietyrelated disorders.…”

mentioning

confidence: 99%

“…4 Being born preterm or with poor foetal growth, defined as being born small for gestational age (SGA), have been associated with various psychiatric disorders. [5][6][7][8][9][10] The rates for preterm births vary globally, but the overall worldwide estimate is 9.6%-11.1%. 11 In Finland, 5%-6% of children are born preterm, 12 before 37 weeks of gestation.…”

mentioning

confidence: 99%

“…Seven register-based studies that examined preterm birth, birth weight or SGA and anxiety disorders were identified. [5][6][7][8][13][14][15] Only two of these specifically reported results on anxiety disorders among children and adolescents. 13,14 One Canadian register study of 7,800 children and adolescents with anxiety disorders reported that being born late preterm or early term increased the odds for anxiety disorders.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Preterm birth, poor foetal growth and anxiety disorders in a Finnish nationwide register sample

et al. 2022

View full text Add to dashboard Cite

Aim We examined the associations between preterm birth, poor foetal growth and anxiety disorders among children and adolescents. Additionally, we examined the impact of common comorbidities and specific anxiety disorders separately. Methods Three Finnish registers provided data on a nationwide birth cohort of 22,181 cases with anxiety disorders and 74,726 controls. Conditional logistic regression was used to examine the associations. Results Extremely very preterm birth and moderate‐late preterm birth were associated with increased adjusted odds ratios (aOR) for anxiety disorders (aOR 1.39, 95% CI 1.11–1.75 and aOR 1.13, 95% CI 1.03–1.23, respectively). Weight for gestational age of less than −2SD (aOR 1.29, 95% CI 1.17–1.42) and −2SD to −1SD (aOR 1.08, 95% CI 1.03–1.14) were associated with increased odds ratios for anxiety disorders. When comorbidities were considered, the associations became statistically insignificant for pure anxiety disorders, but remained significant in the groups with comorbid depressive or neurodevelopmental disorders. Conclusion Preterm birth and poor foetal growth increased the odds for anxiety disorders. However, the associations seem to be explained by the conditions of comorbid depressive and neurodevelopmental disorders. Comorbidities should be considered when examining and treating child and adolescent anxiety disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Preterm birth, poor foetal growth and anxiety disorders in a Finnish nationwide register sample

et al. 2022

View full text Add to dashboard Cite

show abstract

An atlas of genetic correlations between gestational age and common psychiatric disorders

Yao

Meng

et al. 2022

Autism Research

View full text Add to dashboard Cite

We aim to systematically explore the potential genetic correlations between five major psychiatric disorders and gestational ages. Genome‐wide association study (GWAS) summary datasets of attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD) in discovery were downloaded from the Psychiatric GWAS Consortium (PGC) website. Suggestive (Raw p < 0.05) genetic associations in the discovery phrase were further replicated in independent GWASs which downloaded from PGC, the FinnGen study or Integrative Psychiatric Research (iPSYCH) website. GWASs of gestational duration, preterm and post‐term birth were derived from previous studies of infants from the Early Growth Genetics (EGG) Consortium, the iPSYCH study, and the Genomic and Proteomic Network for Preterm Birth Research (GPN). We calculated genetic correlations using linkage disequilibrium score (LDSC) regression. Mendelian randomization (MR) analyses were performed to investigate the causal effects. We identified four suggestive genetic correlations between psychiatric disorders and gestational age factors in discovery LDSC and two replicated in a confirmation LDSC: gestational duration and ADHD (rg = −0.1405, FDR p = 0.0406), post‐term birth and SCZ (rg = −0.2003, FDR p = 0.0042). We also observed causal effect of post‐term birth on SCZ by MR (PWeighted median = 0.037, PInverse variance weighted = 0.007). Our analysis suggested no significant evidence of horizontal pleiotropy and heterogeneity. This study showed the genetic correlation evidences between gestational age phenotypes and psychiatric disorders, providing novel clues for understanding the pathogenic factors of common psychiatric disorders. Lay Summary Whereas gestational age factors were reported to be associated with psychiatric disorders, the genetic relationship and causality remain to be revealed. The present study reported the first large‐scale genetic correlations investigation of the associations between gestational age phenotypes and psychiatric disorders. Results indicate causal relationships between post‐term birth and schizophrenia (SCZ), as well as suggestive genetic correlations between gestational duration and attention deficit/hyperactivity disorder (ADHD). This study provided novel clues for understanding the pathogenic factors of common psychiatric disorders.

show abstract

Exposures during pregnancy and at birth are associated with the risk of offspring eating disorders

Ozsvar,

Gissler,

Lavebratt

et al. 2023

Intl J Eating Disorders

View full text Add to dashboard Cite

BackgroundEating disorders (ED) are severe psychiatric disorders, commonly debuting early. Aberrances in the intrauterine environment and at birth have been associated with risk of ED. Here, we explore if, and at what effect size, a variety of such exposures associate with offspring ED, that is, anorexia nervosa (AN), bulimia nervosa (BN), and eating disorder not otherwise specified (EDNOS).MethodsThis population‐based cohort study, conducted from September 2021 to August 2023, used Finnish national registries of all live births in 1996–2014 (N = 1,097,753). Cox proportional hazards modeling was used to compare ED risk in exposed versus unexposed offspring, adjusting for potential confounders and performing sex‐stratified analyses.ResultsA total of 6614 offspring were diagnosed with an ED; 3668 AN, 666 BN, and 4248 EDNOS. Lower risk of offspring AN was seen with young mothers, continued smoking, and instrumental delivery, while higher risk was seen with older mothers, inflammatory disorders, prematurity, small for gestational age, and low Apgar. Offspring risk of BN was higher with continued smoking and prematurity, while lower with postmature birth. Offspring risk of EDNOS was lower with instrumental delivery, higher for older mothers, polycystic ovary syndrome, insulin‐treated pregestational diabetes, antibacterial treatment, prematurity, and small for gestational age. Sex‐specific associations were found.ConclusionsSeveral prenatal and at birth exposures are associated with offspring ED; however, we cannot exclude confounding by maternal BMI. Nevertheless, several exposures selectively associate with risk of either AN, BN, or EDNOS, and some are sex‐specific, emphasizing the importance of subtype‐ and sex‐stratified analyses of ED.Public SignificanceWe define environmental factors involved in the development of different ED, of importance as preventive measure, but also in order to aid in defining the molecular pathways involved and thus in the longer perspective contribute to the development of pharmacological treatment of ED.

show abstract

Rates of Neuropsychiatric Disorders and Gestational Age at Birth in a Danish Population

Cited by 16 publications

References 62 publications

Preterm birth, poor foetal growth and anxiety disorders in a Finnish nationwide register sample

Preterm birth, poor foetal growth and anxiety disorders in a Finnish nationwide register sample

An atlas of genetic correlations between gestational age and common psychiatric disorders

Exposures during pregnancy and at birth are associated with the risk of offspring eating disorders

Contact Info

Product

Resources

About