Ratio of fetal anteroposterior to transverse cerebellar diameter for detection of the cerebellar hypoplasia in the second trimester and comparison with trisomy 18

Takano, Mayumi; Hirata, Hiroko; Kagawa, Yukiko; Murata, Susumu; Fujiwara, Masazumi; Nakata, Masahiko

doi:10.1111/jog.12795

Cited by 5 publications

(6 citation statements)

References 12 publications

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“…Ultrasound examinations were performed using an ARIETTA 60 or 70 ultrasound machine (Hitachi, Ltd.) and a GE Voluson E8 ultrasound machine (GE Healthcare UK Ltd.). Fetal TCD and APCD were measured as previously described . In brief, we identified the cerebellar hemispheres in the posterior fossa of the plane that was obtained by slightly rotating the transducer below the thalamic plane.…”

Section: Methodsmentioning

confidence: 99%

“…A small transverse cerebellar diameter (TCD) and enlarged cisterna magna have been reported in trisomy 18, but evaluation of these areas, particularly in the early second trimester, is often normal. Our previous study and a study by Hayata et al . both showed that a small anteroposterior cerebellar diameter (APCD) is a complication of trisomy 18.…”

Section: Introductionmentioning

confidence: 94%

“…both showed that a small anteroposterior cerebellar diameter (APCD) is a complication of trisomy 18. Additionally, we reported that the ratio of APCD to TCD (APCD/TCD ratio) could be a useful index to detect trisomy 18 in the second trimester . However, cerebellar biometric information for the assessment of fetal cerebellar hypoplasia is still limited.…”

Section: Introductionmentioning

confidence: 99%

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Utility of fetal anteroposterior to transverse cerebellar diameter ratio to exclude cerebellar hypoplasia in trisomy 18

Takano

Nakata

Oji

et al. 2018

J of Obstet and Gynaecol

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Utility of fetal anteroposterior to transverse cerebellar diameter ratio to exclude cerebellar hypoplasia in trisomy 18

Takano

Nakata

Oji

et al. 2018

J of Obstet and Gynaecol

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“…Starting at 28 weeks of gestation, the references deviate from each other, e. g. the TCD in the third trimester is larger according to Verburg than according to Snijders and Goldstein [16]. Other standards for size parameters are published: ratio of anteroposterior (AP) to transverse cerebellar diameter [21], circumference and area of the cerebellar hemispheres [22].…”

Section: Transcerebellar Diameter (Tcd)mentioning

confidence: 99%

The Fetal Posterior Fossa on Prenatal Ultrasound Imaging: Normal Longitudinal Development and Posterior Fossa Anomalies

Pertl¹,

Eder²,

Stern³

et al. 2019

Ultraschall in Med

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Fetal neurosonography and the assessment of the posterior fossa have gained in importance during the last 2 decades primarily due to the development of high-resolution ultrasound probes and the introduction of 3 D sonography. The anatomical development of the posterior fossa can be visualized well with the newest ultrasound technologies. This allows better knowledge of the anatomical structures and helps with understanding of the development of malformations of the posterior fossa. In this article the longitudinal development of the posterior fossa structures will be reviewed. The embryologic description will be compared with ultrasound descriptions. These embryologic and anatomic illustrations form the basis for the screening and diagnosis of malformations of the posterior fossa. During the first trimester, screening for open spina bifida as well as cystic malformations of the posterior fossa is possible. In the second and third trimester, malformations of the posterior fossa can be subdivided into 3 groups: fluid accumulation in the posterior fossa (Dandy-Walker malformation, Blake’s pouch cyst, mega cisterna magna, arachnoid cyst, vermian hypoplasia), decreased cerebellar biometrics (volume) (cerebellar hypoplasia, pontocerebellar hypoplasia) and suspicious cerebellar anatomy (Arnold-Chiari malformation, rhombencephalosynapsis, Joubert syndrome). This algorithm, in combination with knowledge of normal development, facilitates the diagnostic workup of malformations of the posterior fossa.

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“…However, CH was the most severe in trisomy 18 than in trisomy 21 and 13 . Anteroposterior cerebellum diameter (APCD) and APCD to transverse cerebellum diameter (TCD) ratio seemed more remarkable and effective for CH than TCD . The aim of this study is to compare CSP/APCD and APCD/TCD ratios in normal fetuses with those in aneuploid fetuses, and to propose a new, simple ratio, CSP/APCD ratio for the identification of fetuses suspected of trisomy 18, and to validate the APCD/TCD ratio which had been studied.…”

Section: Introductionmentioning

confidence: 99%

The ratio of cavum septi pellucidi width to anteroposterior cerebellar diameter: A novel index as a diagnostic adjunct for prenatal diagnosis of trisomy 18

Xie

et al. 2019

J of Obstet and Gynaecol

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Aim To explore the effectiveness of cavum septi pellucidi (CSP) width to anteroposterior cerebellar diameter (APCD) ratio as a diagnostic adjunct for prenatal diagnosis of trisomy 18. Methods Images of normal fetal brain within 15 and 35 weeks were stored in our center from 2016 to 2017. Images of aneuploid fetuses were retrospectively collected from 2004 to 2017. The transverse cerebellar diameter, APCD and CSP width were measured. CSP/APCD and APCD/transverse cerebellar diameter ratios were calculated and compared between euploid and aneuploid fetuses. Results One thousand and forty one fetuses were analyzed, including 817 euploid fetuses and 224 aneuploid fetuses (trisomy 21 117 cases, trisomy 18 82 cases, trisomy 13 9 cases, sex‐linked 16 cases). No correlation had been found between both ratios and gestational weeks (P > 0.05). In aneuploid groups, means of ratios were both significantly different just between trisomy 18 group and euploid group (P < 0.05). The best area under the curve was shown by the CSP/APCD ratio. The cutoff value of CSP/APCD was 0.46 (sensitivity 87.0%, specificity 85.0%). Conclusion A wide CSP or cerebellar hypoplasia warrants a more detailed ultrasound screening and genetic counseling. A larger CSP/APCD ratio alerts us to trisomy 18 syndrome, especially in cases with subtle anomalies.

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Ratio of fetal anteroposterior to transverse cerebellar diameter for detection of the cerebellar hypoplasia in the second trimester and comparison with trisomy 18

Cited by 5 publications

References 12 publications

Utility of fetal anteroposterior to transverse cerebellar diameter ratio to exclude cerebellar hypoplasia in trisomy 18

Utility of fetal anteroposterior to transverse cerebellar diameter ratio to exclude cerebellar hypoplasia in trisomy 18

The Fetal Posterior Fossa on Prenatal Ultrasound Imaging: Normal Longitudinal Development and Posterior Fossa Anomalies

The ratio of cavum septi pellucidi width to anteroposterior cerebellar diameter: A novel index as a diagnostic adjunct for prenatal diagnosis of trisomy 18

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