2021
DOI: 10.1021/acs.chemrestox.1c00208
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Ratio of Propylene Glycol to Glycerol in E-Cigarette Reservoirs Is Unchanged by Vaping As Determined by 1H NMR Spectroscopy

Abstract: E-cigarette liquids (e-liquids) contain propylene glycol (PG) and/or glycerol (GL) to deliver flavorants/nicotine. It has recently been suggested that the PG:GL ratio in ecigarette reservoirs changes during vaping, leaving almost entirely GL after aerosolizing much of a 30:70 PG:GL mixture. To evaluate this directly, we analyzed e-liquids from e-cigarettes before and after aerosolization using 4 different coils, and aerosol samples generated using high and low e-liquid levels. The PG:GL ratios of initial and f… Show more

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Cited by 3 publications
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“…The most common determination methods are based on gas chromatography in combination with different detectors, either flame ionization [18][19][20] or mass spectrometry [21,22]. Some of the techniques for the determination of glycerol, propylene glycol, and nicotine are based on proton nuclear magnetic resonance ( 1 HNMR) [23][24][25]. Despite these efforts, to the best of the author's knowledge, there is no method that uses liquid chromatography coupled with mass spectrometry (LC-MS) or tandem mass spectrometry (LC-MS/MS) in determination of nicotine, propylene glycol, and glycerol.…”
Section: Introductionmentioning
confidence: 99%
“…The most common determination methods are based on gas chromatography in combination with different detectors, either flame ionization [18][19][20] or mass spectrometry [21,22]. Some of the techniques for the determination of glycerol, propylene glycol, and nicotine are based on proton nuclear magnetic resonance ( 1 HNMR) [23][24][25]. Despite these efforts, to the best of the author's knowledge, there is no method that uses liquid chromatography coupled with mass spectrometry (LC-MS) or tandem mass spectrometry (LC-MS/MS) in determination of nicotine, propylene glycol, and glycerol.…”
Section: Introductionmentioning
confidence: 99%