Ratiometric and absolute water-soluble fluorescent tripodal zinc sensor and its application in killing human lung cancer cells

Abstract

A new "naked-eye" and ratiometric fluorescent zinc sensor (TAQ) of carboxamidoquinoline with 2-chloro-N-(quinol-8-yl)-acetamide as a receptor was designed and synthesized. The sensor shows good water solubility and high selectivity for sensing; about a 15-fold increase in fluorescence quantum yield and a 100 nm red-shift of fluorescence emission upon binding Zn²⁺ in aqueous HEPES buffer solution are observed. The human lung cancer cell line (A549) activity is also demonstrated.

Fluorescence signaling of Zn2+ levels in synthetic urine by dipicolylamine-armed hydroxynaphthalimide

“…Tel. : +82 2 820 5199; fax: +82 2 825 4736. small-molecule-based sensors have been devised using the fluorophores of fluorescein [13,14], coumarin [15,16], 7-nitrobenz-2-oxa-1,3-diazole (NBD) [17,18], quinoline [19], and naphthalimide [20]. The most frequently used ligating sites for the recognition of Zn 2+ ions are dipicolylamine (DPA), macrocyclic aza-crown-ethers, and iminodiacetate moieties [21].…”

Novel Rearrangement Followed by Ring Contraction of Highly Selective and Sensitive Turn‐On Chromogenic and Fluorescent Chemodosimeters for Cu2+ Ions

“…The excellent ability to sense Cu 2+ ions is reflected in the limit of detection of 4.38 μ m for compound 1 and 2.64 μ m for compound 2 . Both 1 and 2 can sense the presence of Cu 2+ ions even in drain water (shown only for compound 1 in Figure S4).…”

Solvent-dependent turn-on probe for dual monitoring of Ag+ and Zn2+ in living biological samples

“…Among a variety of investigated ions, special attentions have been devoted to Ag + and Zn 2+ , due to their significant roles in environmental science, biology, medicine, and imaging industry [5][6][7][8]. To date, there are many reported sensors for Ag + and Zn 2+ , respectively [9][10][11][12][13]. However, relatively few dual functional sensors for both Ag + and Zn 2+ have been seen in literature.…”