Ratiometric co-delivery of hydroxychloroquine and calculated low-dose paclitaxel efficiently suppresses tumor growth in hepatocellular carcinoma mouse models in vivo

Wang, Wenbin; Sun, Hui; Gong, Yi; Liu, Xiangsheng; Liu, Xiao; Wang, Mengru; Li, Silu; Li, Jiulong; Zhu, Lin; Meng, Huan

doi:10.1016/j.nantod.2022.101446

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…Recently, many studies on combination of PTX with immune-associated drugs 184 , 185 , 186 , gene drugs 187 , 188 , 189 , 190 , 191 , 192 , anti-inflammatory drugs 193 , phototherapy-involved drugs 123 , 194 , 195 , anti-angiogenic agents 153 , autophagy inhibitors 196 , 197 , neuroregenerative drugs 198 , and P-glycoprotein inhibitors 199 , have attracted much attention. Modifying PTX with the above antitumor agents is a facile approach to achieve the synchronous combination.…”

Section: The Molecular Self-assembled Strategy Of Ptx Nanodrugsmentioning

confidence: 99%

Self-assembled nanoformulations of paclitaxel for enhanced cancer theranostics

Pei

Jiang

Hao

et al. 2023

Acta Pharmaceutica Sinica B

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Section: The Molecular Self-assembled Strategy Of Ptx Nanodrugsmentioning

confidence: 99%

Self-assembled nanoformulations of paclitaxel for enhanced cancer theranostics

Pei

Jiang

Hao

et al. 2023

Acta Pharmaceutica Sinica B

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“…(2) Liposomes also achieve drug co-delivery and synergistic effects. Wang et al [ 29 ] designed a liposomal nanocarrier using a thin-film hydrophobic method that co-encapsulated the autophagy inhibitor hydroxychloroquine (HCQ) and PTX to effectively inhibit tumor growth. Li et al [ 30 ] developed a nanocomposite (AuNS@ZrTCPP-GA, AZG) based on glycyrrhetinic acid (GA), gold nanostar (AuNS), tetra (4-carboxyphenyl) porphyrin (TCPP), and Zr 4+ .…”

Section: Nano-delivery Systems Loaded With Antitumor Active Ingredien...mentioning

confidence: 99%

Smart Targeted Delivery Systems for Enhancing Antitumor Therapy of Active Ingredients in Traditional Chinese Medicine

Kang

Wang

et al. 2023

Molecules

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As a therapeutic tool inherited for thousands of years, traditional Chinese medicine (TCM) exhibits superiority in tumor therapy. The antitumor active components of TCM not only have multi-target treatment modes but can also synergistically interfere with tumor growth compared to traditional chemotherapeutics. However, most antitumor active components of TCM have the characteristics of poor solubility, high toxicity, and side effects, which are often limited in clinical application. In recent years, delivering the antitumor active components of TCM by nanosystems has been a promising field. The advantages of nano-delivery systems include improved water solubility, targeting efficiency, enhanced stability in vivo, and controlled release drugs, which can achieve higher drug-delivery efficiency and bioavailability. According to the method of drug loading on nanocarriers, nano-delivery systems can be categorized into two types, including physically encapsulated nanoplatforms and chemically coupled drug-delivery platforms. In this review, two nano-delivery approaches are considered, namely physical encapsulation and chemical coupling, both commonly used to deliver antitumor active components of TCM, and we summarized the advantages and limitations of different types of nano-delivery systems. Meanwhile, the clinical applications and potential toxicity of nano-delivery systems and the future development and challenges of these nano-delivery systems are also discussed, aiming to lay the foundation for the development and practical application of nano-delivery systems of TCM in clinical settings.

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Development of Injectable Thermosensitive Nanocomposite Hydrogel for Ratiometric Drug Delivery to Treat Drug Resistant Chondrosarcoma In Vivo

Zhu,

Wei,

et al. 2024

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Chondrosarcoma(CS), a prevalent primary malignant bone tumor, frequently exhibits chemotherapy resistance attributed to upregulated anti‐apoptosis pathways such as the Bcl‐2 family. In this manuscript, a new strategy is presented to augment chemosensitivity and mitigate systemic toxicity by harnessing a nano‐enabled drug delivery hydrogel platform. The platform utilizes “PLGA‐PEG‐PLGA”, an amphiphilic triblock copolymer combining hydrophilic polyethylene glycol (PEG) and hydrophobic polylactide glycolide (PLGA) blocks, renowned for its properties conducive to crafting a biodegradable, temperature‐sensitive hydrogel. This platform is tailored to encapsulate a ratiometrically designed dual‐loaded liposomes containing a first‐line chemo option for CS, Doxorubicin (Dox), plus a calculated amount of small molecule inhibitor for anti‐apoptotic Bcl‐2 pathway, ABT‐737. In vitro and in vivo evaluations demonstrate successful Bcl‐2 suppression, resulting in the restoration of Dox sensitivity, evident through impeded tumor growth and amplified necrosis rates at the tumor site. This delivery system showcases remarkable thermal responsiveness, injectability, and biodegradability, all finely aligned with the clinical demands of CS treatment. Collectively, this study introduces a transformative avenue for tackling drug resistance in CS chemotherapy, offering significant clinical potential.

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Ratiometric co-delivery of hydroxychloroquine and calculated low-dose paclitaxel efficiently suppresses tumor growth in hepatocellular carcinoma mouse models in vivo

Cited by 5 publications

References 39 publications

Self-assembled nanoformulations of paclitaxel for enhanced cancer theranostics

Self-assembled nanoformulations of paclitaxel for enhanced cancer theranostics

Smart Targeted Delivery Systems for Enhancing Antitumor Therapy of Active Ingredients in Traditional Chinese Medicine

Development of Injectable Thermosensitive Nanocomposite Hydrogel for Ratiometric Drug Delivery to Treat Drug Resistant Chondrosarcoma In Vivo

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