Ratiometric fluorescent signals-driven smartphone-based portable sensors for onsite visual detection of food contaminants

Shen, Yizhong; Wei, Yingjin; Zhu, Chao; Cao, Jinxuan; Han, Deman

doi:10.1016/j.ccr.2022.214442

Cited by 155 publications

(56 citation statements)

References 146 publications

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“…However, the single-wavelength emission of it easily suffered interferences from the test environment changes and instrument parameters. In contrast, the dual-emission ratiometric fluorescence assay possessed a favorable feature of the built-in self-calibration to address these obstacles. − Although several AIE-based ratiometric fluorescent probes have been designed for a ClO – response, they have mainly focused on cell or in vivo imaging through cumbersome chemical preparation, − and there was a very rare concern for their applications in food safety assessment.…”

Section: Introductionmentioning

confidence: 99%

Aggregation-Induced Emission Fluorophore-Incorporated Curcumin-Based Ratiometric Nanoprobe for Hypochlorite Detection in Food Matrices

Shen

Nie

Zhu

et al. 2022

J. Agric. Food Chem.

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The development of efficient, economic, reliable, and accurate monitoring of hypochlorite (ClO − ) in food matrices is in great demand for food safety assessment, particularly during its massive use against the COVID-19 epidemic. Here, we prepared an aggregation-induced emission (AIE) fluorophore tetraphenylethylene (TPE)-incorporated curcumin-based hybrid ratiometric fluorescence nanoprobe (Curcumin/TPE@HyNPs) through amphiphilic phospholipid polymer-powered nanoprecipitation, which exhibited a fast, highly sensitive, and selective response to the residual ClO − in real food matrices. Because of the inner filter effect (IFE) from curcumin toward TPE inside the nanoprobe, the bright fluorescence of TPE aggregation at ∼437 nm was effectively quenched, along with an enhanced fluorescence of curcumin at ∼478 nm. Once there was a ClO − residue in food matrices, ClO − triggered the oxidation of o-methoxyphenol inside curcumin and led to the almost complete absorption collapse, thereby terminating curcumin fluorescence at ∼478 nm and the IFE process. Accordingly, the fluorescence of TPE at ∼437 nm was recovered. In this case, a ratiometric fluorescent response of Curcumin/TPE@HyNPs toward the residual ClO − in food matrices (e.g., milk) was proposed with a low detection limit of 0.353 μM and a rapid response time of 140.0 s. Notably, the phospholipid polymer as the protection layer effectively reduced/evaded the nonspecific binding of signal reporters inside the nanoprobe, facilitating it to directly monitor the residual ClO − in real food matrices. This work provided a novel approach to utilize the unconventional AIE luminophors for constructing the efficient and reliable early warning mechanisms toward various food contaminants.

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Section: Introductionmentioning

confidence: 99%

Aggregation-Induced Emission Fluorophore-Incorporated Curcumin-Based Ratiometric Nanoprobe for Hypochlorite Detection in Food Matrices

Shen

Nie

Zhu

et al. 2022

J. Agric. Food Chem.

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“…Characteristically, these are very costly large instruments with complex operational procedures, and they require time-taking sample detection procedures and professional manpower; they also restrict sample preconcentration procedures. [5][6][7][8][9][10][11] Hitherto, despite their outreach, these conventional strategies are being constrained within sophisticated laboratories. These limitations make them suitable for real-time, point-of-care (POC), in situ, and on-site detection.…”

mentioning

confidence: 99%

“…These devices are fast, economic, simple, and portable analytical techniques; these characteristics have helped them gain considerable attention for the on-site detection of various food contaminants. [1][2][3][4][5][6][7][8][9][10]12 Among the various sensing strategies, colorimetric, fluorescence, and electrochemical assays are widely used candidates for the detection of contaminants. [3][4][5][6][7]9 These assays exhibited great promise for food quality and food safety, which are highly suitable for the execution of onsite sensing of food contaminants, especially in the resource-limited settings.…”

mentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10]12 Among the various sensing strategies, colorimetric, fluorescence, and electrochemical assays are widely used candidates for the detection of contaminants. [3][4][5][6][7]9 These assays exhibited great promise for food quality and food safety, which are highly suitable for the execution of onsite sensing of food contaminants, especially in the resource-limited settings. Actually, up to now, onsite sensing strategies are still designated as significant desirable assays for simply attaining accurate information about the contaminants in foods, both rapidly and at the point of care.…”

mentioning

confidence: 99%

“…Effective portable sensing devices aim to achieve precise on-site monitoring of toxic food contaminants, which is immensely important for safeguarding food safety and human health. [3][4][5][6][7][8][9] Portable Electrochemical Devices for On-Site Detection of Food Contaminants…”

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confidence: 99%

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Review—Emerging Trends in the Development of Electrochemical Devices for the On-Site Detection of Food Contaminants

et al. 2022

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Traditional laboratory-based sensing strategies for food contaminant detection are often limited because they are time consuming and expensive and require trained personnel, which makes them unsuitable for routine sensing. Therefore, the scientific and industrial community is showing enormous interest in the design and development of portable sensing devices for the on-site and point-of-care detection of food contaminants. Portability is one of the chief characteristic features of designing contemporary analytical devices. Portable devices have received tremendous attention, as these novel devices have advanced the field of sensing. Various sensing strategies have been utilized for on-site detection of food contaminants. Among these, portable electrochemical devices have emerged vigorously in the past few years. Scientists and industrialists have worked tirelessly to develop portable electrochemical devices for a minute amount of food contaminant detection in water bodies and food products. The current work aims to demonstrate recent research progress related to the design, development, and improvement of portable electrochemical devices for detection of food contaminants.

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Polyphenol‐based Materials as Sensors: Recent Trends in Chemo‐ and Bio‐sensing

Wei,

Feng,

Wang

2024

Science and Engineering of Polyphenols

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Ratiometric fluorescent signals-driven smartphone-based portable sensors for onsite visual detection of food contaminants

Cited by 155 publications

References 146 publications

Aggregation-Induced Emission Fluorophore-Incorporated Curcumin-Based Ratiometric Nanoprobe for Hypochlorite Detection in Food Matrices

Aggregation-Induced Emission Fluorophore-Incorporated Curcumin-Based Ratiometric Nanoprobe for Hypochlorite Detection in Food Matrices

Review—Emerging Trends in the Development of Electrochemical Devices for the On-Site Detection of Food Contaminants

Polyphenol‐based Materials as Sensors: Recent Trends in Chemo‐ and Bio‐sensing

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