Rational choice of antibacterial drug for the treatment of ent organs in outpatient practice

Eremin, Sergei A.; Рязанцев, С. В.; Коноплёв, О. И.

doi:10.21518/2079-701x-2018-20-8-12

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…В Москве заболеваемость ОРС составляет 1420 случаев на 100 тыс. взрослого населения [5]. Для ОРС характерна сезонность: заболеваемость растет осенью, зимой и ранней весной и значительно снижается в теплое время года.…”

Section: Introductionunclassified

“…ОРС, как правило, возникает в результате вирусной инфекции, которая попадает в околоносовые пазухи из полости носа через естественные соустья, т.е. не может протекать изолированно [5,12]. Развитие воспалительного процесса сопровождается активным выбросом провоспалительных медиаторов, деструкцией мерцательного эпителия, развитием отека, что приводит к инактивации мукоцилиарного транспорта и нарушению аэрации синусов [13].…”

Section: Introductionunclassified

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Topical therapy in the treatment of patients with acute rhinosinusitis in adults

Старостина¹,

Sivokhin²

2021

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Acute rhinosinusitis is one of the most common diseases in the world, characterized by acute inflammatory processes in the nasal cavity and paranasal sinuses, lasting less than 4 weeks. According to statistics, in Russia, this disease is recorded in 6–15% of the population annually, in European countries in every seventh person, while there is a tendency to an increase in the incidence. Acute viral rhinosinusitis has the highest incidence among all rhinosinusitis and occurs in most patients in a mild form, however, untimely treatment of inflammation of the nasal mucosa can lead to obstruction of the natural anastomoses, impaired physiological ventilation and drainage of the paranasal sinuses, stagnation of secretions with further development acute bacterial rhinosinusitis. The overuse of local vasoconstrictor drugs (intranasal decongestants) leads to the development of drug-induced rhinitis, long-term imbalance of autonomic innervation of the nasal mucosa and edema, called "rebound syndrome". In the article we consider the issues of etiology, pathogenesis, features of the course of rhinosinusitis. The principles of differential diagnosis of viral and bacterial rhinosinusitis are stated, taking into account the latest recommendations and research in this area. The features of the use of the most frequently used topical preparations in acute rhinosinusitis in the practice of an ENT doctor have been analyzed.

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Section: Introductionunclassified

Topical therapy in the treatment of patients with acute rhinosinusitis in adults

Старостина¹,

Sivokhin²

2021

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Antimicrobial Activity of Dioxidine and Dioxidine-Containing Medicine «nosolin-Ultra, Nasal Drops»

Detusheva

Fursova

Korovkin³

2020

RCLD

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The study is devoted to the study of the antimicrobial activity of the antioxidant dioxidin and the complex dioxin-containing preparation Nosolin-ultra, nasal drops against planktonic and biofilm cultures of pathogens of ENT infections, the dynamics of the formation of microbial resistance to dioxidine. 11 reference strains and 9 clinical strains of microorganisms were used in the study: Streptococcus spp., Staphylococcus spp., Micrococcus luteus, Haemophilus influenzae, Acinetobacter pittii, Klebsiella pneumoniae, Moraxella catarrhalis, Pseudomonas aeruginosa. The antimicrobial activity of preparations against planktonic cultures was determined by serial dilution in broth and spot method on solid nutrient media, against biofilms by the applicator method. The dynamics of dioxidine resistance formation was studied by passaging cultures in a liquid nutrient medium with increasing concentrations of antiseptic. Based on the study, it was found that Dioxidin showed antimicrobial activity against plankton cells of all strains (MBC=0.08-5 mg/ml), except S. pyogenes SN345 (MBC>5 mg/ml), inhibited the growth of formed biofilms (MBC=0.08-2.5 mg/ml) of all strains except S. pyogenes SN345 (MBC>5 mg/ml). The drug «Nosolin-ultra, nasal drops» was highly active against plankton cells (MBC=0.04-0.63 mg/ml) and biofilms (MBC=0.02-0.31 mg/ml) of gram-negative bacteria, except A. pittii (MBC>2.5 mg/ml), less active against plankton cells (MBC=1.25-2.5 mg/ml) and biofilms (MBC=0.02-0.31 mg/ml) of gram-positive bacteria and C. albicans. One strain (S. aureus) formed a variant resistant to dioxidine at a concentration of 20 mg/ml, which exceeded the concentration of dioxidine in the complex preparation; other strains (P. aeruginosa, K. pneumoniae, C. albicans) did not form such variants. The data obtained indicate that the drug «Nosolin-ultra, nasal drops» can be effectively used against most pathogens of ENT infections. It is worth noting that with prolonged use of the drug for some types of ENT pathogens in the future, a slight decrease in effectiveness may be noted.

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Systemic antibiotic therapy of patients with acute bacterial sinusitis taking into account resistance

Старостина

Sivokhin

2021

Medicinskij sovet

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Acute rhinosinusitis is one of the most common diseases in the world. According to statistics, about 10 million cases are registered in Russia every year.Acute bacterial rhinosinusitis (ABRS) in most cases develops as a result of an acute respiratory viral disease, proceeds easily and it does not require antibiotic therapy. However, it significantly reduces the patient's quality of life in cases of moderate and severe disease, and in the absence of timely treatment, can lead to intracranial complications (meningitis, encephalitis, intracranial abscesses, etc.) and orbital (reactive edema of the eyelid, phlegmon of the orbit, periorbital abscesses, etc.). To avoid complications, with exacerbation of rhinosinusitis, it is necessary to choose the right antibiotic therapy, taking into account the resistance of the microorganisms that caused the disease.The article describes the differential diagnosticprinciples of bacterial rhinosinusitis according to the latest recommendations and research in this area, the most common antibiotic-resistant pathogens in the practice of an ENT doctor are presented, the issue of choosing the correct systemic antibiotic therapy for the treatment of patients with moderate and severe acute bacterial rhinosinusitis is considered according to modern data on the sensitivity of bacterial pathogens to antibacterial drugs prescribed in the otorhinolaryngologist's practice. The article presents data on a new universal cephalosporin of the 3rd generation (the active ingredient is cefditoren), as a second- and third-line drug, due to its high activity against most causative agents of acute bacterial rhinosinusitis, and clinical observation using the above antibacterial agent within the framework of the considered topics.

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Rational choice of antibacterial drug for the treatment of ent organs in outpatient practice

Cited by 4 publications

References 14 publications

Topical therapy in the treatment of patients with acute rhinosinusitis in adults

Topical therapy in the treatment of patients with acute rhinosinusitis in adults

Antimicrobial Activity of Dioxidine and Dioxidine-Containing Medicine «nosolin-Ultra, Nasal Drops»

Systemic antibiotic therapy of patients with acute bacterial sinusitis taking into account resistance

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