Directional liquid dynamics show significant interest across various fields, including energy, environmental remediation, water harvesting, microfluidics, and heat transfer. Nature creatures have developed remarkable abilities to manipulate liquid through their distinct surface structures and chemical compositions, offering valuable insights for human endeavors. Understanding the fundamental principles governing liquid dynamics at the interfaces of liquids, air, and solids is crucial for developing novel technologies and solutions in diverse domains. By elucidating the underlying mechanisms of directional liquid dynamics in natural organisms, we can inspire innovative approaches for practical applications. This review aims to provide a comprehensive understanding of directional liquid dynamics by (1) exploring the fundamental principles governing liquid dynamics at interfaces, (2) introducing the underlying mechanisms of directional liquid dynamics in representative natural organisms, (3) presenting a range of innovations and applications inspired by natural phenomena, and (4) offering our insights into the current unresolved questions and persistent challenges within the realm of directional liquid dynamics on superwetting interfaces. By delineating these objectives, we aim to contribute to the advancement of knowledge in this critical area and pave the way for future research and technological developments.