Rational design of a small organic photosensitizer for NIR-I imaging-guided synergistic photodynamic and photothermal therapy

Lv, Shibo; Liu, Yuhan; Zhao, Yanliang; Lv, Fangyuan; Feng, Enmin; Liu, Dapeng; Song, Fengling

doi:10.1039/d2bm00661h

Cited by 8 publications

(3 citation statements)

References 58 publications

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“…Multimodal phototherapy was also achieved by TPA–BTZ, which showed NIR‐I emission at 800 nm and could generate ROS via mechanisms of both type I and type II for enhanced PDT upon irradiation. [ 175 ] TPA–BTZ had the propeller‐like TPA rotators that facilitated heat generation for PTT by intramolecular rotation. After being encapsulated with DSPE–mPEG 2000 via a nanoprecipitation method, the intermolecular spatial isolation created by alkyl chainsin the formed TPA–BTZ@PEG 2000 NPs allowed a sufficient intramolecular motion for PCE.…”

Section: Cancer Theranostics Based On Aiegensmentioning

confidence: 99%

Aggregation‐induced emission luminogens for in vivo molecular imaging and theranostics in cancer

et al. 2023

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Cancer is one of the most fatal diseases for decades. Aggregation‐induced emission luminogens (AIEgens) have been recently used as molecular imaging or therapeutic agents in cancers, due to the advantages of large Stokes shift, high quantum yield, great biocompatibility, and strong photostability. AIEgens can specifically target different types of cancer via diverse targeting strategies. AIEgen‐based fluorescence imaging, especially near‐infrared imaging, demonstrated deep penetration and suitable signal‐to‐noise ratio, which allows reliable in vivo cancer imaging. Combined with other imaging modalities, AIEgen‐based multimodal imaging could provide multidimensional cancer hallmarks from different perspectives. In addition, AIEgen‐based phototherapy can be used for photodynamic therapy and photothermal therapy, which facilitate ablation of cancer cells with good biosafety and high therapeutic effects in vivo. AIEgens nanoparticles fabricated with some specific chemicals, drugs, or siRNA, could display synergistic therapeutic effects for cancers. This paper comprehensively describes the current status and future perspectives of AIEgens, which have showed a great potential for the future preclinical and clinical translation on in vivo molecular imaging and theranostics in cancer.

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Section: Cancer Theranostics Based On Aiegensmentioning

confidence: 99%

Aggregation‐induced emission luminogens for in vivo molecular imaging and theranostics in cancer

et al. 2023

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“…However, PDT, as practiced clinically, is an oxygen-dependent treatment mode that limits its curative effect due to the hypoxic environment of tumor tissues. 8 Indeed, several PDT photosensitizers have received FDA approvals for specific indications. 9 Comparatively, current photothermal agents require relatively higher concentrations or light doses to exert photothermal efficiency.…”

Section: Introductionmentioning

confidence: 99%

Endoplasmic reticulum-targeted NIR-II phototherapy combined with inflammatory vascular suppression elicits a synergistic effect against TNBC

Wan

Chen

et al. 2023

Biomater. Sci.

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“…Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), [ 7 ] is receiving increasing attention due to its advantages of localized treatment and controllable irradiation and having emerged as a new paradigm for drug delivery. Photodynamic therapy (PDT) depends on the levels of light‐dependent reactive oxygen species (ROS) induced by photosensitizers.…”

Section: Introductionmentioning

confidence: 99%

Nano‐Econazole Enhanced PD‐L1 Checkpoint Blockade for Synergistic Antitumor Immunotherapy against Pancreatic Ductal Adenocarcinoma

Qin

Tian

et al. 2023

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Insufficienct T lymphocyte infiltration and unresponsiveness to immune checkpoint blockade therapy are still major difficulties for the clinical treatment of pancreatic ductal adenocarcinoma (PDAC). Although econazole has shown promise in inhibiting PDAC growth, its poor bioavailability and water solubility limit its potential as a clinical therapy for PDAC. Furthermore, the synergistic role of econazole and biliverdin in immune checkpoint blockade therapy in PDAC remains elusive and challenging. Herein, a chemo‐phototherapy nanoplatform is designed by which econazole and biliverdin can be co‐assembled (defined as FBE NPs), which significantly improve the poor water solubility of econazole and enhance the efficacy of PD‐L1 checkpoint blockade therapy against PDAC. Mechanistically, econazole and biliverdin are directly released into the acidic cancer microenvironment, to activate immunogenic cell death via biliverdin‐induced PTT/PDT and boost the immunotherapeutic response of PD‐L1 blockade. In addition, econazole simultaneously enhances PD‐L1 expression to sensitize anti‐PD‐L1 therapy, leading to suppression of distant tumors, long‐term immune memory effects, improved dendritic cell maturation, and tumor infiltration of CD8+T lymphocytes. The combined FBE NPs and α‐PDL1 show synergistic antitumor efficacy. Collectively, FBE NPs show excellent biosafety and antitumor efficacy by combining chemo‐phototherapy with PD‐L1 blockade, which has promising potential in a precision medicine approach as a PDAC treatment strategy.

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Rational design of a small organic photosensitizer for NIR-I imaging-guided synergistic photodynamic and photothermal therapy

Abstract: Developing a small molecular photosensitizer to achieve multimodal phototherapy has recently garnered attention as a promising strategy for efficient cancer treatment. However, synthesis of a multifunctional small molecular photosensitizer has...

Cited by 8 publications

References 58 publications

Aggregation‐induced emission luminogens for in vivo molecular imaging and theranostics in cancer

Aggregation‐induced emission luminogens for in vivo molecular imaging and theranostics in cancer

Endoplasmic reticulum-targeted NIR-II phototherapy combined with inflammatory vascular suppression elicits a synergistic effect against TNBC

Nano‐Econazole Enhanced PD‐L1 Checkpoint Blockade for Synergistic Antitumor Immunotherapy against Pancreatic Ductal Adenocarcinoma

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