Rational design of a trypanocidal peptide derived from Dinoponera quadriceps venom

Monteiro, Marília Lopes; Lima, Dânya Bandeira; Freire, Katielle Albuquerque; Pedron, Cibele Nicolaski; Magalhães, Emanuel Paula; Silva, Brenna Pinheiro; García-Jareño, Alicia Belén; Oliveira, Cyntia Silva de; Nunes, João Victor Serra; Marinho, Márcia Machado; Menezes, Ramon Róseo Paula Pessoa Bezerra de; Orzáez, Mar; Oliveira, Vani Xavier; Martins, Alice Maria Costa

doi:10.1016/j.ejmech.2022.114624

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…M-PONTX-Dq3a is an AMP isolated from the venom of the ant species Dinoponera quadriceps. Two fragments derived from this AMP (M-PONTX-Dq3a [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] and [Lys] 3 -M-PONTX-Dq3a [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]) have been demonstrated to possess trypanocidal activities similar to those of the parent peptide against all three forms of the T. cruzi Y strain but with lower toxicity, better bioavailability, and a lower cost of production [146,147]. Due to their reduced peptide lengths, both fragments reached the clinical application phase.…”

Section: Amps and Cpps To Combat T Cruzi Infectionmentioning

confidence: 99%

Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas Disease

Robledo,

Pérez-Silanes,

Fernández-Rubio

et al. 2023

Pathogens

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In 2020, the WHO established the road map for neglected tropical diseases 2021–2030, which aims to control and eradicate 20 diseases, including leishmaniosis and Chagas disease. In addition, since 2015, the WHO has been developing a Global Action Plan on Antimicrobial Resistance. In this context, the achievement of innovative strategies as an alternative to replace conventional therapies is a first-order socio-sanitary priority, especially regarding endemic zoonoses in poor regions, such as those caused by Trypanosoma cruzi and Leishmania spp. infections. In this scenario, it is worth highlighting a group of natural peptide molecules (AMPs and CPPs) that are promising strategies for improving therapeutic efficacy against these neglected zoonoses, as they avoid the development of toxicity and resistance of conventional treatments. This review presents the novelties of these peptide molecules and their ability to cross a whole system of cell membranes as well as stimulate host immune defenses or even serve as vectors of molecules. The efforts of the biotechnological sector will make it possible to overcome the limitations of antimicrobial peptides through encapsulation and functionalization methods to obtain approval for these treatments to be used in clinical programs for the eradication of leishmaniosis and Chagas disease.

show abstract

Section: Amps and Cpps To Combat T Cruzi Infectionmentioning

confidence: 99%

Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas Disease

Robledo,

Pérez-Silanes,

Fernández-Rubio

et al. 2023

Pathogens

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show abstract

“…Two fragments of the AMP M-PONTX-Dq3a, isolated from the Dinoponera quadriceps ant venom are M-PONTX-Dq3a [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] and [Lys] 3 -M-PONTX-Dq3a [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Both fragments have been demonstrated to possess trypanocidal activities similar to those of the parent peptide against all three forms of T. cruzi Y strain but with lower toxicity, better bioavailability and lower cost of production [144,145]. Due to their reduced peptide length, both fragments would have a better chance of reaching clinical application.…”

Section: Amps and Cpps To Combat T Cruzi Infectionmentioning

confidence: 99%

Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas

Robledo,

Pérez-Silanes,

Fernández-Rubio

et al. 2023

Preprint

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In 2020, the WHO established a road map for neglected tropical diseases 2021−2030 that aims to control and eradicate 20 diseases, including Leishmaniosis and Chagas disease. In addition, since 2015, the WHO has been developing a Global Action Plan on Antimicrobial Resistance. In this context, the achievement of innovative strategies as an alternative to replace conventional therapies is a first-order socio-sanitary priority, especially regarding endemic zoonoses in poor regions such as those caused by Trypanosoma cruzi and Leishmania spp infections. In this scenario, it is worth highlighting a group of natural peptide molecules (AMPs and CPPs) that are promising strategies for improving therapeutic efficacy against these neglected zoonoses, avoiding the development of toxicity and resistance of conventional treatments. This review presents the novelties of these peptide molecules and their ability to cross a whole system of cell membranes, as well as to stimulate the host immune defenses or even serve as a vector of molecules. The efforts of the biotechnological sector will make it possible to overcome the limitations of antimicrobial peptides through encapsulation and functionalization methods to obtain approval for these treatments to be used in clinical programs for the eradication of Leishmaniosis and Chagas disease.

show abstract

“…Proteo-transcriptomic investigations conducted on a panel of Hymenoptera now allow us to appreciate the full complexity of venoms and will accelerate the delineation of the biological activity of venom peptides. In particular, the analysis of ant, wasp, or velvet ant venoms, coupled with functional assays, has already identified several new insecticidal, 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 antimicrobial, 10 , 11 , 18 , 19 , 20 , 21 , 22 anthelminthic 15 , 23 , 24 and pain-causing 10 , 25 , 26 , 27 peptides. These studies led to the description of the hyperdiverse peptide gene superfamily, called aculeatoxins, which appears to be widespread in Hymenoptera particularly in ant venoms.…”

Section: Introductionmentioning

confidence: 99%

The mechanism underlying toxicity of a venom peptide against insects reveals how ants are master at disrupting membranes

Ascoët¹,

Touchard²,

Téné³

et al. 2023

iScience

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Rational design of a trypanocidal peptide derived from Dinoponera quadriceps venom

Cited by 7 publications

References 20 publications

Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas Disease

Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas Disease

Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas

The mechanism underlying toxicity of a venom peptide against insects reveals how ants are master at disrupting membranes

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