Rational Design of Cancer-Targeted Benzoselenadiazole by RGD Peptide Functionalization for Cancer Theranostics

Yang, Li‐Ye; Li, Wenying; Huang, Yanyu; Zhou, Yangliang; Chen, Tianfeng

doi:10.1002/marc.201500243

Cited by 16 publications

(18 citation statements)

References 31 publications

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“…First, CS‐RP was synthesized through an amidation reaction of CS, RC‐12, and PG‐6 peptide ,,. Briefly, solutions of RC‐12 and PG‐6 peptide (5 mg) were dissolved in DMSO (1 mL), and then EDC and NHS were added with stirring for 2 h at ambient temperature and pressure.…”

Section: Methodssupporting

confidence: 90%

Dual‐Targeted Selenium Nanoparticles for Synergistic Photothermal Therapy and Chemotherapy of Tumors

Fang

Zheng

et al. 2018

Chemistry An Asian Journal

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A combination of chemo- and photothermal therapy has emerged as a promising tactic for cancer therapy. However, the intricacy of accurate delivery and the ability to initiate drug release in specific tumor sites remains a challenging puzzle. Hence, to assure that the chemotherapeutic drug and photothermal agent are synchronously delivered to a tumor area for their synergistic effect, dual-target (RC-12 and PG-6 peptides) functionalized selenium nanoparticles loaded with both doxorubicin (DOX) and indocyanine green (ICG) were designed and successfully synthesized. The as-synthesized nanoparticles exhibited good monodispersity, size stability, and consistent spectral characteristics compared with those of ICG or DOX alone. The nanoparticles underwent self-immolated cleavage under irradiation from a near-IR laser and released the loaded drug owing to sufficient hyperthermia. Moreover, the internalized nanoparticles triggered the overproduction of intracellular reactive oxygen species to induce cell apoptosis. Taken together, this study provides a sequentially triggered nanosystem to achieve precise drug delivery by chemo-photothermal combination.

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Section: Methodssupporting

confidence: 90%

Dual‐Targeted Selenium Nanoparticles for Synergistic Photothermal Therapy and Chemotherapy of Tumors

Fang

Zheng

et al. 2018

Chemistry An Asian Journal

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“…This compound also enhanced the sensitivity of cancerous cells to X-ray induced apoptosis by inhibition of TrxR, with good results in vitro and in vivo . Related benzo[ c ][1,2,5]selenadiazole-5-carboxylic acid was conjugated into polyethylenimine (PEI) nanoparticles with RGD (Arg-Gly-Asp) peptide as integrin targeting molecule, achieving good selectivity in human glioma cells and provoking apoptosis by ROS-mediated p53 phosphorylation pathway . Conjugation in mesoporous silica nanoparticles (MSNs) improved blood–brain barrier (BBB) permeability and cellular uptake in glioma cells, achieving cell death .…”

Section: 25-selenadiazolesmentioning

confidence: 99%

Development and Therapeutic Potential of Selenazo Compounds

et al. 2019

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Incorporation of selenium (Se) atom into small molecules can substantially enhance their antioxidant, antiinflammatory, antimutagenic, antitumoral or chemopreventive, antiviral, antibacterial, antifungal, antiparasitic, and neuroprotective effects. Specifically, selenazo compounds have received great attention owing to their chemical properties, pharmaceutical applications, and low toxicity. In this Perspective, we compile extensive literature evidence with the description and discussion of the most recent advances in different selenazo and selenadiazo motifs as potential pharmacological candidates. We also provide some perspectives on the challenges and future directions in the advancement of these selenazo compounds, each of which could generate drug candidates for various diseases.

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“…In recent years, with the rapid development of oncology and nanomaterials, nanodrug delivery systems (NDDS) have shown remarkable therapeutic effects in tumor diagnosis and treatment, and a variety of nanodrug carriers have been applied to tumor treatment [ 10 , 11 , 12 , 13 ]. Compared with drug delivery methods, NDDS have the advantages of improving drug utilization, achieving stimulated release, and reducing drug toxicity and side effects [ 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

CRPC Membrane-Camouflaged, Biomimetic Nanosystem for Overcoming Castration-Resistant Prostate Cancer by Cellular Vehicle-Aided Tumor Targeting

Lü

et al. 2022

IJMS

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Castration-resistant prostate cancer (CRPC) is the most common malignant tumor of the male urinary system. Nanodrug delivery systems (NDDS) have been widely applied in drug delivery for tumor therapy; however, nanotherapeutics encounter various biological barriers that prevent successful accumulation of drugs, specifically at diseased sites. Therefore, there is an urgent need to develop a CRPC-targeting nanocomposite with fine biocompatibility for penetrating various biological barriers, delivering sufficient drugs to the targeting site and improving therapeutic efficiency. In this work, CRPC cell membranes were firstly adapted as biomimetic vectors for the encapsulating PEG−PLGA polymer containing the chemotherapy drug docetaxel (DTX). The CRPC membrane-camouflaged nanoparticles can easily escape early recognition by the immune system, penetrate the extracellular barrier, and evade clearance by the circulatory system. In addition to the characteristics of traditional nanoparticles, the CRPC cell membrane contains an arsenal of highly specific homotypic moieties that can be used to recognize the same cancer cell types and increase the targeted drug delivery of DTX. In vivo fluorescence and radionuclide dual-model imaging were fulfilled by decorating the biomimetic nanosystem with near-infrared dye and isotope, which validated the homotypic targeting property offered by the CRPC cell membrane coating. Importantly, remarkably improved therapeutic efficacy was achieved in a mice model bearing CRPC tumors. This homologous cell membrane enabled an efficient drug delivery strategy and enlightened a new pathway for the clinical application of tumor chemotherapy drugs in the future.

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Rational Design of Cancer-Targeted Benzoselenadiazole by RGD Peptide Functionalization for Cancer Theranostics

Cited by 16 publications

References 31 publications

Dual‐Targeted Selenium Nanoparticles for Synergistic Photothermal Therapy and Chemotherapy of Tumors

Dual‐Targeted Selenium Nanoparticles for Synergistic Photothermal Therapy and Chemotherapy of Tumors

Development and Therapeutic Potential of Selenazo Compounds

CRPC Membrane-Camouflaged, Biomimetic Nanosystem for Overcoming Castration-Resistant Prostate Cancer by Cellular Vehicle-Aided Tumor Targeting

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