Rational Design of Conjugated Photosensitizers with Controllable Photoconversion for Dually Cooperative Phototherapy

Ye, Shuyue; Rao, Jiaming; Qiu, Shihong; Zhao, Jinglong; He, Hui; Yan, Ziling; Yang, Tao; Deng, Yibin; Ke, Hengte; Yang, Hong; Zhao, Yuliang; Guo, Zhengqing; Chen, Huabing

doi:10.1002/adma.201806346

Cited by 22 publications

(23 citation statements)

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“…BDP‐based conjugated polymers (including oligomer) are widely applied into optoelectronics, few are reported in the biological field. Ye et al reported BDP conjugated dimer and trimer ( BDP 16 , Figure and Table ) for PDT and PTT (Figure b) (Ye et al, ). The mixture of BDP and amphiphilic polymer called poly(ethylene glycol)‐ b ‐poly(caprolactone) (PEG‐PCL) could self‐assemble into nanoparticles.…”

Section: Physical Encapsulationmentioning

confidence: 99%

Tailoring nanoparticles based on boron dipyrromethene for cancer imaging and therapy

Lin

Colombani-Garay

Huang

et al. 2020

WIREs Nanomed Nanobiotechnol

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Boron dipyrromethene (BODIPY), as a traditional fluorescent dye, has drawn increasing attention because of its excellent photophysical properties like adjustable spectra and outstanding photostability. BODIPY dyes could be assembled into nanoparticles for cancer imaging and therapy via rational design. In this review, the bio‐applications of BODIPY‐containing nanoparticles are introduced in detail, such as cellular imaging, near‐infrared fluorescence imaging, computed tomography imaging, photoacoustic imaging, phototherapy, and theranostics. The construction strategies of BODIPY‐containing nanoparticles are emphasized so the review has three sections—self‐assembly of small molecules, chemical conjugation with hydrophilic compounds, and physical encapsulation. This review not only summarizes various and colorific bio‐applications of BODIPY‐containing nanoparticles, but also provides reasonable design methods of BODIPY‐containing nanoparticles for cancer theranostics. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging

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Section: Physical Encapsulationmentioning

confidence: 99%

Tailoring nanoparticles based on boron dipyrromethene for cancer imaging and therapy

Lin

Colombani-Garay

Huang

et al. 2020

WIREs Nanomed Nanobiotechnol

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“…The system could deplete intracellular glutathione and thus enhance the PDT outcome (Hu et al, ). Apart from ICG, other PSs or nanocomposites such as self‐assembled PS micelles, polymeric vesicles, gold nanstructures, cypate, and naphthalocyanine also have absorption in the NIR region (Guo et al, ; He et al, ; Taratula, Schumann, Duong, Taylor, & Taratula, ; Vankayala, Huang, Kalluru, Chiang, & Hwang, ; Yang et al, ; Ye et al, ). The nanocomposites have the ability of changing physic‐chemical properties of PS.…”

Section: Nanocarriers Used In Deep Pdtmentioning

confidence: 99%

Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers

Zhao

Wang

et al. 2019

WIREs Nanomed Nanobiotechnol

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Photodynamic therapy (PDT) has been used in the treatment of cancers and other benign diseases for several years in clinic. However, the hypoxia of tumors and the penetration limitation of excitation light to tissues can dramatically reduce the efficacy of PDT to cancers. To overcome these drawbacks, various assembled nanocarriers such as nanoparticles, nanocapsules, nanocrystals, and so on were introduced. The assembled nanocarriers have the ability of loading photosensitizers, delivering O2 into tumors, generating O2 in situ in tumors, as well as turning near‐infrared (NIR) light, X‐rays, and chemical energy into ultraviolet or visible light. Therefore, it is easy for the nanocarriers to improve the hypoxia microenvironment or increase the treatment depth of cancers, which will improve the efficiency of PDT to some degree. In recent years, a number of investigations were focused on these subjects. We will summarize the advances of nanocarriers in PDT, especially in O2 introduction PDT and deep PDT. The perspectives, challenges, and potential in translation of PDT will also be discussed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology‐Inspired Nanomaterials > Lipid‐Based Structures Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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“…Photochemical internalization (PCI) is recently used as a promising technology to overcome the membrane barrier of the endocytic vesicles 205. This technology is mainly based on the use of photosensitizers located in the endocytic vesicles that under light irradiation induces lysosomal membrane disruption and release macromolecules from the compartmentalization 206. So far, various nanostructures have been constructed relying on this mechanism.…”

Section: Biological Applications Of Light-responsive Nanomaterialsmentioning

confidence: 99%

Precise cell behaviors manipulation through light-responsive nano-regulators: recent advance and perspective

Thang¹,

Wang²,

Lü

et al. 2019

Theranostics

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Nanotechnology-assisted spatiotemporal manipulation of biological events holds great promise in advancing the practice of precision medicine in healthcare systems. The progress in internal and/or external stimuli-responsive nanoplatforms for highly specific cellular regulations and theranostic controls offer potential clinical translations of the revolutionized nanomedicine. To successfully implement this new paradigm, the emerging light-responsive nanoregulators with unparalleled precise cell functions manipulation have gained intensive attention, providing UV-Vis light-triggered photocleavage or photoisomerization studies, as well as near-infrared (NIR) light-mediated deep-tissue applications for stimulating cellular signal cascades and treatment of mortal diseases. This review discusses current developments of light-activatable nanoplatforms for modulations of various cellular events including neuromodulations, stem cell monitoring, immunomanipulation, cancer therapy, and other biological target intervention. In summary, the propagation of light-controlled nanomedicine would place a bright prospect for future medicine.

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Rational Design of Conjugated Photosensitizers with Controllable Photoconversion for Dually Cooperative Phototherapy

Cited by 22 publications

References 0 publications

Tailoring nanoparticles based on boron dipyrromethene for cancer imaging and therapy

Tailoring nanoparticles based on boron dipyrromethene for cancer imaging and therapy

Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers

Precise cell behaviors manipulation through light-responsive nano-regulators: recent advance and perspective

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