Rational design of core–shell molecularly imprinted polymer based on computational simulation and Doehlert experimental optimization: application to the separation of tanshinone IIA from Salvia miltiorrhiza Bunge

Jia, Xianjun; Li, Hong; Luo, Jing; Lü, Qing; Peng, Yan; Shi, Lei; Liu, Liping; Du, Shouying; Zhang, Guijun; Chen, Lina

doi:10.1007/s00216-012-6078-4

Cited by 23 publications

(18 citation statements)

References 45 publications

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“…MIPs are robust, highly selective, workable in organic solvent, low cost, and could be casted in bulk, making it an attractive candidate in natural product extraction. In a recent study, an MIPs system has been established using core-shell structural nanoparticles and optimized by Doehlet design and computational modeling [41]. It exhibited large capacity, high recognition selectivity and fast kinetics in the separation of tanshinone IIA from crude extracts of S. miltiorrhiza .…”

Section: Sources Of Tanshinones Preparative and Analytical Methodmentioning

confidence: 99%

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Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities

Zhang

Jiang

et al. 2012

IJMS

223

157

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Tanshinones are a class of abietane diterpene compound isolated from Salvia miltiorrhiza (Danshen or Tanshen in Chinese), a well-known herb in Traditional Chinese Medicine (TCM). Since they were first identified in the 1930s, more than 40 lipophilic tanshinones and structurally related compounds have been isolated from Danshen. In recent decades, numerous studies have been conducted to investigate the isolation, identification, synthesis and pharmacology of tanshinones. In addition to the well-studied cardiovascular activities, tanshinones have been investigated more recently for their anti-cancer activities in vitro and in vivo. In this review, we update the herbal and alternative sources of tanshinones, and the pharmacokinetics of selected tanshinones. We discuss anti-cancer properties and identify critical issues for future research. Whereas previous studies have suggested anti-cancer potential of tanshinones affecting multiple cellular processes and molecular targets in cell culture models, data from in vivo potency assessment experiments in preclinical models vary greatly due to lack of uniformity of solvent vehicles and routes of administration. Chemical modifications and novel formulations had been made to address the poor oral bioavailability of tanshinones. So far, human clinical trials have been far from ideal in their design and execution for the purpose of supporting an anti-cancer indication of tanshinones.

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Section: Sources Of Tanshinones Preparative and Analytical Methodmentioning

confidence: 99%

“…It exhibited large capacity, high recognition selectivity and fast kinetics in the separation of tanshinone IIA from crude extracts of S. miltiorrhiza . The recovery yield of tanshinone IIA reached 93% with a one-step extraction and its purity was more than 98% [41]. …”

Section: Sources Of Tanshinones Preparative and Analytical Methodmentioning

confidence: 99%

Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities

Zhang

Jiang

et al. 2012

IJMS

223

157

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“…Then, 5 mL of ammonia was added into the above solution under magnetic stirring (500 r min −1 ) at room temperature and the mixture was allowed to react for 24 h. Finally, the products were separated from the mixed solution by centrifugation and washed with ethanol to remove the residual ammonia 11-13 .…”

Section: Methodsmentioning

confidence: 99%

“…Nevertheless, they exhibit some disadvantages, including incomplete template removal, low rebinding capacity, slow binding kinetics, poor site accessibility to target species and irregular shape 10,11 . One of the main reasons for these disadvantages is that the template molecules are located in the interior area of the MIPs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of surface nano-molecularly imprinted polymers for sensitive baicalin detection in biological samples

Wang

et al. 2015

RSC Adv.

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Surface molecularly imprinted polymers (MIP@SBA-15) imprinted on the surface of hybrid nanostructured organic/inorganic materials (SBA-15) were prepared for the selective extraction and detection of baicalin (BA) from biological samples. The surface morphologies and characteristics of the imprinted and non-imprinted polymers were characterized by Fourier transform infrared (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermo–gravimetric analysis (TGA) and nitrogen adsorption–desorption isotherms. The results indicated that the polymers were successfully grafted on the surface of SBA-15 and possessed a highly ordered mesoporous structure. In binding tests, MIP@SBA-15 reached saturated adsorption within 80 min and exhibited significant specific recognition toward BA with large adsorption capacity. Meanwhile, the prepared MIP@SBA-15 was used as a selective sorbent for solid-phase extraction of BA from biological samples. Recoveries of BA from the liver and spleen ranged from 90.6% to 90.9% with RSD < 3.7%. All these results reveal that this method is simple, rapid and sensitive for effectively extracting and detecting trace BA in biological samples.

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“…This fact has provoked an overuse of certain standard formulations (i.e. the typical 1:4:20 template:monomer: cross-linker molar ratio) [17].…”

Section: Molecularly Imprinted Solid-phase Extractionmentioning

confidence: 99%

Molecularly Imprinted Polymers for the Detection of Food Toxins: A Minireview

Saini¹,

Kaur²

2013

ANP

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Food contamination from natural or anthropogenic sources poses severe risks to human health. It is now largely accepted that continuous exposure to low doses of food Toxins such as mycotoxins, phycotoxins can be related to several chronic diseases, including some type of cancer and serious hormonal dysfunctions. Contemporary analytical methods have the sensitivity required for contamination detection and quantification, but direct application of these methods on real samples can be rarely performed because of matrix complexity. Thus, selective analytical methods, relying on intelligent functional materials are needed. Recent years have seen the increasing use of molecular imprinted polymers in contaminant analysis in food because these materials seem to be particularly suitable for applications where analyte selectivity is essential. It offers several advantages to the agrofood industry in areas such as analysis, sensoring, extraction, or preconcentration of components. It has the potential of becoming a tool for acquiring truly simple, rapid, and robust direct measurements.

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Rational design of core–shell molecularly imprinted polymer based on computational simulation and Doehlert experimental optimization: application to the separation of tanshinone IIA from Salvia miltiorrhiza Bunge

Cited by 23 publications

References 45 publications

Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities

Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities

Synthesis of surface nano-molecularly imprinted polymers for sensitive baicalin detection in biological samples

Molecularly Imprinted Polymers for the Detection of Food Toxins: A Minireview

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