Rational design of molecular phototheranostic platform for NIR-II fluorescence imaging guided chemodynamic-photothermal combined therapy

Tumor Microenvironment-Responsive One-for-All Molecular-Engineered Nanoplatform Enables NIR-II Fluorescence Imaging-Guided Combinational Cancer Therapy

“…The optical data of the reported molecular IR-FEP, FTEP, and FTEP-TBFc NPs are summarized in Figure e,f. According to the previous work of our group, − compared to IR-FEP NPs [λ ex /λ em = 777/1047 nm; quantum yields (QYs) = 2.0%], the FTEP NPs (λ ex /λ em = 824/1100 nm; QY = 1.0%) have an enhanced electron-feeding capacity and the conjugation length due to the inserted thiophene (as the second donor units), which reduces the energy band gap, effectively driving absorption and emission to longer wavelengths. The FTE-functionalized product FTEP-TBFc NPs (λ ex /λ em = 800/1092 nm; QY = 0.8%) exhibited a weak blue-shift in absorption and emission and maintained stable NIR-II fluorescence imaging properties.…”

“…Therefore, the depletion of intracellular GSH could elude tumor resistance to redox imbalance for improving the efficacy of CDT and PDT and downregulate glutathione peroxidase 4 (GPX4) to elicit the increase of lipid hydroperoxides to induce the ferroptosis process . As evidenced in our prior research, the combination of PTT/CDT or PTT/PDT has proven effective in attaining the intended therapeutic outcome . Nonetheless, ensuring the safety and clinical appropriateness of low-power treatments while maintaining the original efficacy aligns with the criteria set forth by the U.S. Food and Drug Administration (FDA) for skin exposure.…”

Iron-chelated semiconducting oligomer nanoparticles for NIR-II fluorescence imaging-guided enhanced chemodynamic/photothermal combination therapy

“…These materials usually can not only generate OH, but also deplete glutathione (GSH) to regulate the redox balance of cancer cells, showing great promise in cancer therapy. [10][11][12] Although CDT has shown great potential, several issues still need to be addressed to further promote its efficacy. During circulation, only a small amount of nanomedicine can accumulate at the tumor site.…”

“…These materials usually can not only generate ˙OH, but also deplete glutathione (GSH) to regulate the redox balance of cancer cells, showing great promise in cancer therapy. 10–12…”

Cu2SnTe3 Nanoparticles for Chemodynamic/Photodynamic /Photothermal Combination Tumor Therapy

“…The temperature increase caused by PTT not only accelerates the production of ∙ OH, but also accelerates the oxidation of intracellular biological substances by ∙ OH, thus causing irreversible damage to cancer cells and improving the effectiveness of CDT in cancer treatment. [ 18 ] In addition, CDT can overcome the limitation of the light penetration problem of PTT and improve the therapeutic effect of PTT. [ 19 ] Therefore, strategies for achieving efficient CDT/PTT synergistic tumor treatment by rationally designed nanomaterials are of great significance.…”