Rational design of multifunctional magnetic mesoporous silica nanoparticle for tumor-targeted magnetic resonance imaging and precise therapy

Chen, Wei‐Hai; Luo, Guo‐Feng; Lei, Qi; Cao, Fengyi; Fan, Jin‐Xuan; Qiu, Wen‐Xiu; Jia, Hui‐Zhen; Hong, Sihui; Fang, Fang; Zhang, Xuan; Zhuo, Ren‐Xi; Zhang, Xian‐Zheng

doi:10.1016/j.biomaterials.2015.10.053

Cited by 131 publications

(68 citation statements)

References 51 publications

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“…156-158 Our group extensively investigated the effect of both dense (dSiO 2 ) and mesoporous (mSiO 2 ) silica shells and their thickness on the MRI relaxation of Gd 3+ -based upconversion nanoparticles (UCNPs) (Fig. 10a).…”

Section: Factors Influencing Relaxivity Of Mri Contrast Agentsmentioning

confidence: 99%

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

et al. 2017

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Magnetic resonance imaging (MRI) is a highly valuable non-invasive imaging tool owing to its exquisite soft tissue contrast, high spatial resolution, lack of ionizing radiation, and wide clinical applicability. Contrast agents (CAs) can be used to further enhance the sensitivity of MRI to obtain information-rich images. Recently, extensive research efforts have been focused on the design and synthesis of high-performance inorganic nanoparticle-based CAs to improve the quality and specificity of MRI. Herein, the basic rules, including the choice of metal ions, effect of electron motion on water relaxation, and involved mechanisms, of CAs for MRI have been elucidated in detail. In particular, various design principles, including size control, surface modification (e.g. organic ligand, silica shell, and inorganic nanolayers), and shape regulation, to impact relaxation of water molecules have been discussed in detail. Comprehensive understanding of how these factors work can guide the engineering of future inorganic nanoparticles with high relaxivity. Finally, we have summarized the currently available strategies and their mechanism for obtaining high-performance CAs and discussed the challenges and future developments of nanoparticulate CAs for clinical translation in MRI.

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Section: Factors Influencing Relaxivity Of Mri Contrast Agentsmentioning

confidence: 99%

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

et al. 2017

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“…Target molecules allow the MSNs to reach the tumor tissue only through a molecular recognition mechanism. Then, once in the internal tissue, the stimuliresponsive capping agent [5,34] permits the release of the drug as a response to internal (change of pH [42][43][44][45], temperature [46][47][48], redox reactions [40,[49][50][51][52]) or external (irradiation with light [53][54][55], magnetic field [55][56][57]) stimuli.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

Nairi¹,

Magnolia²,

Piludu³

et al. 2018

Colloids and Surfaces B: Biointerfaces

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Mesoporous silica nanoparticles (MSNs) were functionalized with amino groups (MSN-NH) and then with hyaluronic acid, a biocompatible biopolymer which can be recognized by CD44 receptors in tumor cells, to obtain a targeting drug delivery system. To this purpose, three hyaluronic acid samples differing for the molecular weight, namely HA (8-15 kDa), HA (30-50 kDa) and HA (90-130 kDa), were used. The MSN-HA, MSN-HA, and MSN-HA materials were characterized through zeta potential and dynamic light scattering measurements at pH = 7.4 and T = 37 °C to simulate physiological conditions. While zeta potential showed an increasing negative value with the increase of the HA chain length, an anomalous value of the hydrodynamic diameter was observed for MSN-HA, which was smaller than that of MSN-HA and MSN-HA samples. The cellular uptake of MSN-HA samples on HeLa cells at 37 °C was studied by optical and electron microscopy. HA chain length affected significantly the cellular uptake that occurred at a higher extent for MSN-NH and MSN-HA than for MSN-HA and MSN-HA samples. Cellular uptake experiments carried out at 4 °C showed that the internalization process was inhibited for MSN-HA samples but not for MSN-NH. This suggests the occurrence of two different mechanisms of internalization. For MSN-NH the uptake is mainly driven by the attractive electrostatic interaction with membrane phospholipids, while MSN-HA internalization involves CD44 receptors overexpressed in HeLa cells.

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“…(16–19) A number of drug-CD complexes have been marketed using the features of CDs, including good bioavailability, reversible binding and release of guest drugs governed by the thermodynamics of the complexes. (16) We hypothesize that loading small molecular MRI contrast agents to a cyclodextrin-containing nanocarrier by the reversible host-guest interaction would benefit from these advantageous features to develop targeted nanoparticular contrast agents for effective cancer molecular MRI and to facilitate the excretion of the contrast agents by their release from the host to minimize the potential contrast related toxic side effects.…”

Section: Introductionmentioning

confidence: 99%

A targeted nanoglobular contrast agent from host-guest self-assembly for MR cancer molecular imaging

2016

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The clinical application of nanoparticular Gd(III) based contrast agents for tumor molecular MRI has been hindered by safety concerns associated with prolonged tissue retention, although they can produce strong tumor enhancement. In this study, a targeted well-defined cyclodextrin-based nanoglobular contrast agent was developed through self-assembly driven by host-guest interactions for safe and effective cancer molecular MRI. Multiple β-cyclodextrins attached POSS (polyhedral oligomeric silsesquioxane) nanoglobule was used as host molecule. Adamantane–modified macrocyclic Gd(III) contrast agent, cRGD (cyclic RGDfK peptide) targeting ligand and fluorescent probe was used as guest molecules. The targeted host-guest nanoglobular contrast agent cRGD-POSS-βCD-(DOTA-Gd) specifically bond to αvβ3 integrin in malignant 4T1 breast tumor and provided greater contrast enhancement than the corresponding non-targeted agent. The agent also provided significant fluorescence signal in tumor tissue. The histological analysis of the tumor tissue confirmed its specific and effective targeting to αvβ3 integrin. The targeted imaging agent has a potential for specific cancer molecular MR and fluorescent imaging.

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Rational design of multifunctional magnetic mesoporous silica nanoparticle for tumor-targeted magnetic resonance imaging and precise therapy

Cited by 131 publications

References 51 publications

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

A targeted nanoglobular contrast agent from host-guest self-assembly for MR cancer molecular imaging

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