Rational design of nanocarriers for mitochondria-targeted drug delivery

Huang, Lihua; Sun, Zonghao; Shen, Qian; Huang, Zhongxi; Wang, Shuangxi; Yang, Naidi; Li, Gongqiang; Wu, Qiong; Wang, Wei; Li, Lin

doi:10.1016/j.cclet.2022.02.047

Cited by 35 publications

(16 citation statements)

References 258 publications

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“…4 The fluorophore with AIE and 3PA activities reported by Tang et al effectively solves the problems faced by traditional fluorophores and they proposed that the strong AIE of the fluorophore contributes to the enhancement of the 3PA signal. 5–7 3PA in the near-infrared region is one of the most prominent nonlinear optical (NLO) effects and 3PF imaging technology utilizes high-order nonlinear local excitation in the NIR-II region (1000–1700 nm), resulting in a significantly improved penetration depth, spatiotemporal resolution, and signal-to-background ratio (SBR). 8,9 The limitation of Abbe's diffraction makes it difficult for traditional optical fluorescence microscopy to observe the nanoscale RNA structure.…”

Section: Introductionmentioning

confidence: 99%

Lighting up RNA-specific multi-photon and super-resolution imaging using a novel zinc complex

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Lighting up RNA-specific multi-photon and super-resolution imaging using a novel zinc complex

et al. 2023

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“…Triphenylphosphine (TPP), a nontoxic molecule with delocalized positive charge, has been widely used as mitochondrial targeting groups (Zielonka et al., 2017 ) for its strong binding affinity to the mitochondrial membrane (Huang et al., 2022 ). For instance, Tan et al.…”

Section: Introductionmentioning

confidence: 99%

The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery

et al. 2023

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In order to precisely deliver celastrol into mitochondria of tumor cells, improve antitumor efficacy of celastrol and overcome its troublesome problems in clinical application, a novel multistage-targeted celastrol delivery system (C-TL/HA) was developed via electrostatic binding of hyaluronic acid (HA) to celastrol-loaded cationic liposomes composed of natural soybean phosphatidylcholine and cholesterol modified with mitochondrial targeting molecular TPP. Study results in this article showed that C-TL/HA successfully transported celastrol into mitochondria, effectively activated apoptosis of mitochondrial pathway, exerted higher tumor inhibition efficiency and lower toxic side effects compared with free celastrol. More importantly, HA coating not only enabled this delivery system to have good stability and safety in vivo , but also increased drug uptake and facilitated tumor targeting through recognizing CD44 receptors rich on the surface of tumor cells. Conclusively, this HA-coated mitochondrial targeting liposomes may provide a prospect for the clinical application of celastrol in tumor therapy.

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“…Recently, more attention has been focused on the development of nanotechnology, biomedicine, and nanocarriers for controllable drug delivery and release to enhance the therapeutic effects and reduce adverse reactions [1][2][3]. Among many factors, nanocarriers have emerged as an effective nanotechnology to load and release drugs [4]. Up to now, various functional materials have been prepared and used as nanocarriers to realize this goal, such as polymer [5], graphene [6], metal oxide [7], quantum dot [8], mesoporous silica [9], and so on.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Metal–Organic-Framework-Based Nanocarriers for Controllable Drug Delivery and Release

et al. 2022

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Metal–organic frameworks (MOFs) have a good designability, a well-defined pore, stimulus responsiveness, a high surface area, and a controllable morphology. Up to now, various MOFs have been widely used as nanocarriers and have attracted lots of attention in the field of drug delivery and release because of their good biocompatibility and high-drug-loading capacity. Herein, we provide a comprehensive summary of MOF-based nanocarriers for drug delivery and release over the last five years. Meanwhile, some representative examples are highlighted in detail according to four categories, including the University of Oslo MOFs, Fe-MOFs, cyclodextrin MOFs, and other MOFs. Moreover, the opportunities and challenges of MOF-based smart delivery vehicles are discussed. We hope that this review will be helpful for researchers to understand the recent developments and challenges of MOF-based drug-delivery systems.

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Rational design of nanocarriers for mitochondria-targeted drug delivery

Cited by 35 publications

References 258 publications

Lighting up RNA-specific multi-photon and super-resolution imaging using a novel zinc complex

Lighting up RNA-specific multi-photon and super-resolution imaging using a novel zinc complex

The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery

Recent Advances in Metal–Organic-Framework-Based Nanocarriers for Controllable Drug Delivery and Release

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