Rational Design of Plasmonic Nanoparticle‐Molecule Complexes for Chirality Sensing^†

Abstract

Comprehensive SummarySensing the chirality of molecules is of great importance to fields such as enantioselective synthesis, pharmaceutical industry, and biomedicine. Plasmonic nanoparticles are ideal candidates for molecular sensing due to their inherent plasmonic properties that significantly enhance their sensitivity to surrounding molecules. Developing plasmonic nanoparticle‐molecule complexes for chirality sensing has drawn enormous attention in recent years due to their intriguing properties and potential applications. Thus, in this review, we believe it is timely to circumnavigate the rational design of plasmonic nanoparticle‐molecule complexes and widen the scope of their emerging applications in chirality sensing. First, we present different fundamental mechanisms for plasmon‐based chirality that are built on the system of plasmonic nanoparticle‐molecule complexes. Second, we review the typical applications of plasmonic nanoparticle‐molecule complexes in chirality sensing. Third, we discuss the emerging biomedical applications that the plasmon‐based chirality has attracted enormous interest. Finally, we provide an outlook on the challenges and opportunities in the field of plasmonic approaches for chirality sensing.This article is protected by copyright. All rights reserved.

Tuning the Geometry and Optical Chirality of Pentatwinned Au Nanoparticles with 5-Fold Rotational Symmetry

“…In organic chemistry, enantiomers consist of the same composition but exhibit significantly different behaviors in biochemical reactions in living organisms. Unlike chiral molecules that have been deeply investigated in both synthetic methodologies and performances in various scenarios, chirality in inorganic materials brings intriguing physiochemical properties; however, is not yet well understood. − In particular, integrating chirality with plasmonic materials has attracted much attention because of their inherent localized surface plasmon resonance (LSPR), which endows their capacity for strong interaction with light. − Artificial chiral plasmonic nanomaterials have emerged as a promising platform in chirality sensing, − enantioselective catalysis, , and biomedicine. − For example, chiral plasmonic nanoparticles (NPs) can be utilized to regulate the course of immunization due to their enantioselectivities. , Therefore, the capability of fine-tuning the geometric chirality and the corresponding circular dichroism (CD) spectra of chiral plasmonic nanostructures has become increasingly important but still represents a significantly challenging task.…”