Rational design of poly(peptide-ester) block copolymers for enzyme-specific surface resorption

Abstract

Tissue resorption and remodeling are pivotal steps in successful healing and regeneration, and it is important to design biomaterials that are responsive to regenerative processes in native tissue. The cell...

Recent research progress on tumour-specific responsive hydrogels

“…Another strategy involves integrating MMP-degradable sequences into primary peptide designs, forming enzyme-responsive hydrogel systems with multidomain peptides and β-hairpin peptides. 74 The rationale behind this approach is to exploit the unique biochemical conditions of the tumour microenvironment. When an enzyme-degradable hydrogel comes into contact with a tumour, the overexpressed enzyme cleaves the peptide in the hydrogel, leading to its degradation.…”