Rational Design of Surface‐Enhanced Raman Scattering Substrate for Highly Reproducible Analysis

Abstract

Surface-enhanced Raman scattering (SERS) is an intense ongoing hot topic due to the ultrahigh sensitivity of intrinsic molecular fingerprint information. However, the reliable SERS analysis is restricted because of the lack of efficient control over the large scale of Raman substrates. With the evolution of nanotechnology, new approaches are being developed to produce substrates with higher reproducibility. In this review, we briefly introduce the factors that affect the reproducibility for SERS analysis. The recent progress in the design of SERSactive substrates is further summarized, including fabrication of uniform nanostructures, accurate control of nanogaps and molecular regulation. In the end, an outlook of the direction of reliable SERS detection is given. Rational design of SERS substrate for high reproducibility analysis Precisely Fabrication of NanostructuresSERS active substrates such as noble metal Au, Ag and Cu are prerequisites for SERS formation, with surface plasmon resonance properties. [10] However, these mental nanomaterials of [a

Self-Organized SERS Substrates with Efficient Analyte Enrichment in the Hot Spots

“…Surface-enhanced Raman spectroscopy (SERS) has already demonstrated its great potential for ultrasensitive chemical analysis of both organic − and inorganic ,, substances (analytes) and is paving its road to real-life applications. − ,,− Any kind of nanostructured noble metal that supports localized surface plasmon resonance (LSPR) and allows enhancement of the Raman signal of the analyte is referred to as the “SERS substrate.” Such plasmonic nanostructures can be formed on dielectric, semiconductor, and metal substrates. The bright perspectives of applications have been stimulating ever-growing research on the development and improvement of various types of SERS substrates for their better sensitivity, stability, and lateral uniformity of SERS intensity. − ,− …”

“…Surface-enhanced Raman spectroscopy (SERS) has already demonstrated its great potential for ultrasensitive chemical analysis of both organic 1 − 9 and inorganic 4 , 10 , 11 substances (analytes) and is paving its road to real-life applications. 1 − 3 , 5 , 12 − 18 Any kind of nanostructured noble metal that supports localized surface plasmon resonance (LSPR) and allows enhancement of the Raman signal of the analyte is referred to as the “SERS substrate.” Such plasmonic nanostructures can be formed on dielectric, semiconductor, and metal substrates.…”

Flexible Substrate of Cellulose Fiber/Structured Plasmonic Silver Nanoparticles Applied for Label-Free SERS Detection of Malathion

“…Much effort has been made to fabricate plasmonic substrates with a pronounced SERS effect [ 9 ]. Common SERS substrates are colloidal noble metal solutions (typically Ag, Au, and Cu) prepared with bottom-up techniques or rigid substrates fabricated using self-assembly, e-beam lithography, nanolithography, as well as the templating method [ 10 , 11 ]. Rigid substrates benefit over suspension systems due to prolonged storage stability and uniformity, and facilitate to a high concentration of coupled nanoparticles with a dramatically increased SERS effect [ 9 , 12 ].…”

Alkoxysilane-Mediated Decoration of Si Nanowires Vertical Arrays with Au Nanoparticles as Improved SERS-Active Platforms

“…A widespread wet-chemical method for synthesizing noble metal NPs involves forming colloidal solutions, possibly employing different precursors, reductants, solvents, and NP capping agents [12,13]. SERS-active transducers can then be fabricated by depositing the plasmonic nanostructures onto the substrates of interest via physical or chemical methods, with examples of excellent control in the geometry, coverage, and roughness (among other parameters) of the active surfaces [14][15][16].…”