Rational design, synthesis and SAR study of novel warfarin analogous of 4-hydroxy coumarin-beta-aryl propanoic acid derivatives as potent anti-inflammatory agents

Pawar, Varsha; Shastri, Lokesh A.; Gudimani, Parashuram; Joshi, Shrinivas D.; Kumbar, Vijay; Sunagar, Vinay A.

doi:10.1016/j.molstruc.2021.132300

Cited by 8 publications

(4 citation statements)

References 41 publications

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“…Coumarin dyes are widely used in uorescent probes because of their low biotoxicity, high uorescence sensitivity, good photostability and easy modi cation of the main chain [22][23][24][25][26][27][28][29][30] . Coumarin derivatives can also be used as uorescence markers or imaging agents to identify tumor lesions and study the subcellular localization of drugs [31][32][33][34][35][36][37][38][39][40][41][42] . In this paper, two novel uorescent probes were synthesized using coumarin with an aldehyde (CHO group) as the uorophore.…”

Section: Introductionmentioning

confidence: 99%

Two Novel coumarin-based fluorescent probes for the detection of Cu2+ and biological applications

Zhang

Huang

Wang

et al. 2023

Preprint

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Large accumulations of copper (Cu) ions in the human body may cause damage, including organ and brain damage. In recent years, studies have proven that a large accumulation of Cu ions can lead to Parkinson's disease and Alzheimer's disease, therefore it is great important to develop novel strategies for detecting trace Cu in environmental and biological samples. In this work, we designed two new coumarin-based colorimetric and fluorescent probes HQ1 and HQ2. These two probes could selectively respond to Cu2+ with obvious color and fluorescence changes, and the presence of other metal ions had no effect on these changes. The two probes also exhibited high sensitivity for Cu2+, with a detection limit as low as 1.81×10-8 M/ 1.57×10-8 M. Notably, the two probes showed potential practical applications and were successfully used for detecting Cu2+ in a test strip, A549 cells and living zebrafish larvae.

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Section: Introductionmentioning

confidence: 99%

Two Novel coumarin-based fluorescent probes for the detection of Cu2+ and biological applications

Zhang

Huang

Wang

et al. 2023

Preprint

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“…Different natural products, including calanolides, calanone, and calophyllolides belong to this category of derivatives. [21] Catalysts, especially eco-friendly materials, play an undeniable role in organic chemistry and synthesis. Another area of interest is the contribution of catalysts to synthesizing heterocyclic compounds using MCRs.…”

Section: Introductionmentioning

confidence: 99%

“…Efficient techniques should be introduced to organic chemistry to synthesize functionalized pyran scaffolds and discover new drugs. Different natural products, including calanolides, calanone, and calophyllolides belong to this category of derivatives [21] . Catalysts, especially eco‐friendly materials, play an undeniable role in organic chemistry and synthesis.…”

Section: Introductionmentioning

confidence: 99%

One‐pot Multicomponent Synthesis of Novel Chromene Derivatives Using New Organic Phosphate Salt Catalysts

Salmalian,

Mahmoodi,

Sheykhan

2023

ChemistrySelect

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A new method for synthesizing chromene derivatives as an essential class of heterocyclic compounds has been reported. This research described synthesizing and identifying three new organic salt catalysts based on phosphate moieties. Among the synthesized new phosphate‐based organic salt catalysts, disodium ethyl (phenyl) amino phosphate (DSEAP) plays an essential role and reusable catalyst for the preparation of chromene derivatives under different reaction conditions following the principles of green chemistry. Cost‐effectiveness, non‐toxicity and easy availability are among the salient features of this environmentally friendly catalyst. Furthermore, the catalyst was satisfactorily recycled up to four times without significant performance degradation in the yield of synthesized chromenes. X‐ray diffraction (XRD), infrared spectroscopy (FT‐IR), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) were employed to illustrate the structural and morphologic characteristics of the catalysts. Some synthesized chromene derivatives, including 4I and 4P, showed good antibacterial and biological antioxidant activity compared to the standard drug, respectively. In this research, DSEAP was used as a heterogeneous catalyst in performing one‐pot 3MCRs of aryl aldehyde, an active methylene group e. g. ethyl acetoacetate or diethyl malonate and 5,5‐dimethyl‐1,3‐cyclohexanedione.

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“…[22][23][24][25][26][27][28][29][30][31][32] Coumarin derivatives can also be used as fluorescence markers or imaging agents to identify tumor lesions and study the subcellular localization of drugs. [33][34][35][36][37][38][39][40][41][42][43][44] The development of a sensor with high selectivity and sensitivity to copper ions remains an important challenge. In this paper, two novel fluorescent probes were synthesized using coumarin with an aldehyde (CHO group) as the fluorophore.…”

Section: Introductionmentioning

confidence: 99%

Two novel coumarin-based fluorescent probes for the detection of Cu²⁺ and biological applications

Zhang,

Huang,

Wang

et al. 2023

Journal of Chemical Research

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Large accumulations of copper (Cu) ions in the human body may cause damage, including organ and brain damage. In recent years, studies have proven that a large accumulation of Cu ions can lead to Parkinson’s disease and Alzheimer’s disease; therefore, it is great important to develop novel strategies for detecting trace Cu in environmental and biological samples. In this work, we designed two new coumarin-based colorimetric and fluorescent probes, HQ1 and HQ2. These two probes could selectively respond to Cu2+ with obvious color and fluorescence changes, and the presence of other metal ions had no effect on these changes. The two probes also exhibited high sensitivity for Cu2+, with a detection limit as low as 1.81 × 10–8 M/1.57 × 10–8 M. Notably, the two probes showed potential practical applications and were successfully used for detecting Cu2+ in a test strip, A549 cells, and living zebrafish larvae.

show abstract

Rational design, synthesis and SAR study of novel warfarin analogous of 4-hydroxy coumarin-beta-aryl propanoic acid derivatives as potent anti-inflammatory agents

Cited by 8 publications

References 41 publications

Two Novel coumarin-based fluorescent probes for the detection of Cu2+ and biological applications

Two Novel coumarin-based fluorescent probes for the detection of Cu2+ and biological applications

One‐pot Multicomponent Synthesis of Novel Chromene Derivatives Using New Organic Phosphate Salt Catalysts

Two novel coumarin-based fluorescent probes for the detection of Cu²⁺ and biological applications

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Rational design, synthesis and SAR study of novel warfarin analogous of 4-hydroxy coumarin-beta-aryl propanoic acid derivatives as potent anti-inflammatory agents

Cited by 8 publications

References 41 publications

Two Novel coumarin-based fluorescent probes for the detection of Cu2+ and biological applications

Two Novel coumarin-based fluorescent probes for the detection of Cu2+ and biological applications

One‐pot Multicomponent Synthesis of Novel Chromene Derivatives Using New Organic Phosphate Salt Catalysts

Two novel coumarin-based fluorescent probes for the detection of Cu2+ and biological applications

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Product

Resources

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Two novel coumarin-based fluorescent probes for the detection of Cu²⁺ and biological applications