2021
DOI: 10.1101/2021.08.21.457230
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Rational Exploration of Fold Atlas for Human Solute Carrier Proteins

Abstract: Solute carrier superfamily (SLC) is the largest group responsible for transmembrane transport of substances in human cells. It includes more than 400 members that can be divided into 65 families according to their physiological function and sequence similarity. Different families of solute transporters can adopt the same or different folds that determines the working mechanism and reflects the evolutionary relationship between SLC members. Analysis of structural data shows that there are 13 different folds in … Show more

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Cited by 4 publications
(4 citation statements)
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“…The numbers of integral transmembrane protein structures lag far behind water-soluble proteins. Recently, several groups have systematically analyzed the known structures and at least 16 different folds of ~ 400 members, 65 families of the solute carrier transporter 52,53 . These studies further provide insights into molecular structures and functions of these transporters.…”
Section: Analysis Of the Hydrophobic Surface Of Native Transporters A...mentioning
confidence: 99%
“…The numbers of integral transmembrane protein structures lag far behind water-soluble proteins. Recently, several groups have systematically analyzed the known structures and at least 16 different folds of ~ 400 members, 65 families of the solute carrier transporter 52,53 . These studies further provide insights into molecular structures and functions of these transporters.…”
Section: Analysis Of the Hydrophobic Surface Of Native Transporters A...mentioning
confidence: 99%
“…Fig.2New membrane proteins. PDB structures for probable flagellin 1 (Q9YAN8; 7TXI[73]), protein-serine O-palmitoleoyltransferase porcupine (Q9H237; 7URD[74]), choline transporter-like protein 1 (Q8WWI5; 7WWB[75]), S-layer protein SlpA (Q9RRB6; 7ZGY[76]), and membrane protein (P0DTC5; 8CTK[77]). Transmembrane segments (dark purple) predicted by TMbed; membrane boundaries (dotted lines: red = outside, blue = inside) predicted by the PPM[45] web server.…”
mentioning
confidence: 99%
“…PDB structures for probable flagellin 1 (Q9YAN8; 7TXI (75)), protein-serine O-palmitoleoyltransferase porcupine (Q9H237; 7URD (76)), choline transporter-like protein 1 (Q8WWI5; 7WWB (77)), S-layer protein SlpA (Q9RRB6; 7ZGY (78)), and membrane protein (P0DTC5; 8CTK (79)). Transmembrane segments (dark purple) predicted by TMbed; membrane boundaries (dotted lines: red=outside, blue=inside) predicted by the PPM (45) web server.…”
Section: Resultsmentioning
confidence: 99%