As for the 2 F 3 hypergeometric function of the formwhere all of parameters are assumed to be positive, we give sufficient conditions on (b 1 , b 2 , b 3 ) for its positivity in terms of Newton polyhedra with vertices consisting of permutations of (a 2 , a 1 + 1/2, 2a 1 ) or (a 1 , a 2 + 1/2, 2a 2 ). As an application, we obtain an extensive validity region of (α, λ, µ) for the inequality x 0 (x − t) λ t µ J α (t) dt ≥ 0 (x > 0).