We present an operator-coefficient version of Sato's infinite-dimensional Grassmann manifold, and τ -function. In this context, the Burchnall-Chaundy ring of commuting differential operators becomes a C*-algebra, to which we apply the Brown-Douglas-Fillmore theory, and topological invariants of the spectral ring become readily available. We construct KK classes of the spectral curve of the ring and, motivated by the fact that all isospectral Burchnall-Chaundy rings make up the Jacobian of the curve, we compare the (degree-1) K-homology of the curve with that of its Jacobian. We show how the Burchnall-Chaundy C*-algebra extension of the compact operators provides a family of operator-valued τ -functions.Mathematics Subject Classification (2010) Primary: 46L08, 19K33, 19K35. Secondary: 13N10, 14H40, 47C15