Rationale and design of the application value of Beijing Vascular Health Stratification (BVHS): predictive value of combined assessment of vascular structure and function for cardiovascular events in general Chinese population

Abstract

Background Vascular endothelial dysfunction, arteriosclerosis and atherosclerotic plaque are well-known risk factors for cardiovascular disease (CVD). Studies on vascular health markers have been well-established, however, there is still a lack of related research on combined vascular structure and function indicators. Method Beijing vascular health stratification (BVHS) is an evaluation system aiming at vascular health, combined the endothelial function, arteriosclerosis, atherosclerotic plaque and vascular lumen stenosis to comprehensively assess the vascular health and grade it. This study will explore the predictive value of the combined evaluation of vascular structure and function for cardiovascular events and assess the predictive value of BVHS and compare it with the existing risk assessment systems. A total of 1500 subjects will be enrolled into the prospective cohort study from a community and will be followed up for at least 3 years from July 1, 2020 to June 30, 2023. Subjects aged 40 or above, without coronary heart disease, stroke or peripheral artery disease, with written informed consent will be included; subjects with end-stage hepatorenal diseases (uremia, renal failure, cirrhosis, liver failure), mental disorders or cognitive disorders, with any other factors that the researcher thinks are not suitable for the study will be excluded. Traditional cardiovascular risk factors will be collected as adjusted confounders. Discussion BVHS is a potential and scientific vascular health evaluation system. The study will be the first to grade vascular health by combing various vascular indicators and explore the prediction value and compare with other risk prediction system in general Chinese population. Trial registration: The trial is registered on http://www.chictr.org.cn/ (ChiCTR2000034085).

Adipose tissue specific insulin resistance and prognosis of nondiabetic patients with ischemic stroke

“…First, inflammation and fibrosis are widely present in the adipose tissue of insulin-resistant patients, and this process is to blame for more ischemic brain injuries, such as stroke and stroke recurrence [ 35 ]. Second, patients with high Adipo-IR frequently have other obesity-related risk factors such as high body mass index, triglycerides, total cholesterol, low-density lipoprotein cholesterol, and a history of hyperlipidemia, which are key players in favoring combined cardiovascular and cerebrovascular events [ 28 , 36 – 38 ]. Third, glucose uptake and lipogenesis are diminished in adipose tissue specific insulin resistance, and lipolysis is repressed to a lesser amount.…”

Vascular Health Promotion Project and Vascular Medicine in China-CCVM2004-2023

“…The BVHS study (ChiCTR2000034085) was initiated in 2020 and is ongoing, combining vascular structural and functional indicators to further validate the predictive value of BVHS for future cardiovascular events. 51…”