Rationale and Design of the Registry for Stones of the Kidney and Ureter (ReSKU): A Prospective Observational Registry to Study the Natural History of Urolithiasis Patients

Chang, Hsin-Wen; Tzou, David T.; Usawachintachit, Manint; Duty, Brian; Hsi, Ryan S.; Harper, Jonathan D.; Sorensen, Mathew D.; Stoller, Marshall L.; Sur, Roger L.; Chi, Thomas

doi:10.1089/end.2016.0648

Cited by 37 publications

(33 citation statements)

References 17 publications

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“…With a limited follow-up duration of 8.8 years and cystinuria duration of 17.5 years, it is also possible that some of the unilateral stone formers will ultimately form stone on the other kidney, and our limited followup period does not truly represent the life-long natural history of cystine stone formation. With an ongoing prospective data registry, including all stone patients at our institution, 21 we expect to observe patients in this cohort closely, along with future cystine stone patients as well as stone formers of all types. This registry effort will help verify the natural history and clinical outcomes from this rare genetic disease in a more meaningful manner and over time will be able to generalize findings related to laterality to different types of kidney stones.…”

Section: Discussionmentioning

confidence: 99%

Clinical Outcomes for Cystinuria Patients with Unilateral Versus Bilateral Cystine Stone Disease

Usawachintachit

Sherer

Hudnall

et al. 2018

Journal of Endourology

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Section: Discussionmentioning

confidence: 99%

Clinical Outcomes for Cystinuria Patients with Unilateral Versus Bilateral Cystine Stone Disease

Usawachintachit

Sherer

Hudnall

et al. 2018

Journal of Endourology

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“…Data collection and study design were approved by the local Committee on Human Research (CHR 14-14533). All case data collected were derived from our ongoing prospectively maintained Registry for Stones of the Kidney and Ureter (ReSKUÔ) 12 with a written consent obtained from all patients. All ureteroscopes used for this study were purchased by the institution for clinical care, and there was no funding or support provided by industry sponsors.…”

Section: Methodsmentioning

confidence: 99%

A Prospective Case–Control Study Comparing LithoVue, a Single-Use, Flexible Disposable Ureteroscope, with Flexible, Reusable Fiber-Optic Ureteroscopes

Usawachintachit

Isaacson

Taguchi

et al. 2017

Journal of Endourology

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Objective: LithoVueÔ is a novel, single-use, digital flexible ureteroscope that was released to the US market in January 2016. There are scant data regarding its performance in humans. Procedural outcomes comparing LithoVue with reusable ureteroscopes are presented in patients undergoing ureteroscopy for upper urinary tract pathology. Patients and Methods: Clinical outcomes between two groups of patients undergoing flexible ureteroscopy for upper urinary tract pathology were analyzed. The first group underwent surgery utilizing LithoVue, and the second group used reusable fiber-optic flexible ureteroscopes. Differences in procedural outcomes, operative times, and time spent in hospital were analyzed using two-tailed t-tests and chi-squared and Fisher's exact tests. Results: One hundred fifteen cases utilizing LithoVue and 65 cases utilizing reusable ureteroscopes were included in this study. Demographics, surgical indications, stone size, location, total stone burden, composition, procedural outcomes, and complications were comparable between groups. For all cases, LithoVue procedures lasted 54.1 -25.7 minutes compared with 64.5 -37.0 minutes for reusable scope procedures ( p < 0.05) and for stone removal cases, 57.3 -25.1 vs 70.3 -36.9 minutes, respectively ( p < 0.05). Scope failure occurred in 4.4% of LithoVue cases and 7.7% of reusable cases ( p = 0.27). Conclusions: LithoVue represents a feasible alternative to reusable ureteroscopes with a low rate of scope failure comparable with reusable ureteroscopes. Its use shortens procedure duration, a finding that warrants further investigation.

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“…Of the 85 urine samples from the KSC or KSP group, 50 had 24‐h urine supersaturation results in close temporal proximity to the spot urine samples on which the KIT assay was performed. Additional clinical/demographic data (Table ) were extracted from the electronic health records and the institutional registry, ReSKU . The estimated GFRs (eGFRs) using the Modification of Diet in Renal Disease formula were calculated for all patients .…”

Section: Resultsmentioning

confidence: 99%

“…After obtaining appropriate institutional review board approval (CHR #14‐14533), all patients of any age presenting to the University of California San Francisco urology clinic for evaluation of stone disease who had clinical and current or prior radiographic evidence of nephrolithiasis were included as part of the Registry for Stones of the Kidney and Ureter (ReSKU) study . Clinical evidence of nephrolithiasis was defined as any upper tract urinary stone demonstrated by imaging performed within the 12 months before clinic presentation or adjudicated passage (i.e.…”

Section: Methodsmentioning

confidence: 99%

Non‐radiological assessment of kidney stones using the kidney injury test (KIT), a spot urine assay

Yang

Sarwal

et al. 2020

BJU International

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A total of 136 spot urine samples from 98 individuals, with and without kidney stone disease, were processed in a predefined assay to measure six DNA and protein markers in order to generate a risk score for the non-invasive detection of nephrolithiasis. From this cohort, 56 individuals had spot, non-timed urine samples collected at the time of radiographically confirmed kidney stones, and 54 demographically matched, healthy controls without kidney stone disease also provided spot, non-timed urine samples. Sixteen individuals with persistent stone disease had more than one urine sample. Using a proprietary microwell-based KIT assay, we measured cell-free DNA (cfDNA), methylated cfDNA, clusterin, creatinine, protein and CXCL10. A KIT stone score was computed across all markers using the prior locked KIT algorithm. The KIT stone score, with a scale of 0 to 100, was then correlated with demographic variables, kidney stone burden, obstructive kidney stone disease, and urine solutes in 24-h urine collections. ResultsThe scaled KIT stone score, a composite of all six biomarkers, readily discriminated individuals with current or prior radiographically confirmed kidney stones from healthy controls without kidney stone disease (P < 0.001). In individuals with nephrolithiasis, KIT stone score also correlated with radiologically measured stone size (P = 0.017) and differentiated patients with a clinical radiological diagnosis of obstructive nephrolithiasis associated with upper renal tract dilatation (P = 0.001). Stone burden as assessed by KIT stone score, however, did not correlate with the any of the traditional measures of 24-h urine solutes or the 24-h urine supersaturation levels. In patients with persistent stone disease, where multiple urine samples were collected over time and after different interventions, the use of KIT stone score could non-invasively track stone burden over time through a spot urine, non-timed urine sample. ConclusionsA random, spot urine-based assay, KIT stone score, can noninvasively detect, quantify and monitor current stone burden, and may thus minimize radiographic exposure for kidney stone detection. The KIT stone score assay may also help monitor stone recurrence risk for patients with nephrolithiasis, without the requirement for 24-h urine collections.

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Rationale and Design of the Registry for Stones of the Kidney and Ureter (ReSKU): A Prospective Observational Registry to Study the Natural History of Urolithiasis Patients

Abstract: ReSKU is a longitudinal prospective nephrolithiasis registry that integrates EHR data, lowering the barriers to performing high quality clinical research and quality outcome assessments in urinary stone disease.

Cited by 37 publications

References 17 publications

Clinical Outcomes for Cystinuria Patients with Unilateral Versus Bilateral Cystine Stone Disease

Clinical Outcomes for Cystinuria Patients with Unilateral Versus Bilateral Cystine Stone Disease

A Prospective Case–Control Study Comparing LithoVue, a Single-Use, Flexible Disposable Ureteroscope, with Flexible, Reusable Fiber-Optic Ureteroscopes

Non‐radiological assessment of kidney stones using the kidney injury test (KIT), a spot urine assay

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