Rationale and Prospects for Rabies Elimination in Developing Countries

Meslin, F. X.; Fishbein, Daniel B.; Matter, Hans C.

doi:10.1007/978-3-642-78490-3_1

Cited by 97 publications

(66 citation statements)

References 15 publications

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“…According to WHO report in 2006, more than 3.3 billion people are at risk for rabies in over 85 countries worldwide 3,4 . About 55 000 deaths from rabies are estimated to occur every year, 99% of which are the consequence of dog bites 5,6 Of these 31 000 are estimated to occur in Asia (20 000 in India alone) and 24 000 in Africa.…”

Section: Introductionmentioning

confidence: 99%

Stray dog trade fuelled by dog meat consumption as a risk factor for rabies infection in Calabar, southern Nigeria

Ekanem¹,

Eyong²,

Philip-Ephraim³

et al. 2014

Afr H. Sci.

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Background: Rabies is a preventable zoonosis with the highest case fatality of any disease in the world. In the developing world, it is transmitted mainly by dog bites. In parts of southern Nigeria, dog meat is a delicacy. Objective: To highlight trade in stray dogs as a major risk factor for rabies in animals and humans in south-south Nigeria. Method: Patients admitted into the University of Calabar Teaching Hospital (UCTH) with a diagnosis of rabies between July and October 2012 were analysed for risk factors, post exposure prophylaxis (PEP), health seeking behaviour and outcome. Focused group interview were also conducted among traders/ handlers of stray dogs. Results: Ten cases of rabies in subjects aged 3 to 52 years were recorded in these five months period. Eight of the cases were male and apparently got infected directly or indirectly through the trade in stray dogs for human consumption. None had proper PEP and all patients died. Conclusion: Stray dog trade, fuelled by eating of dog meat, is a risk factor for human and animal rabies in Calabar, southern Nigeria. Culling of stray dogs, control of stray dogs' trade and public enlightenment on PEP is recommended.

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Section: Introductionmentioning

confidence: 99%

Stray dog trade fuelled by dog meat consumption as a risk factor for rabies infection in Calabar, southern Nigeria

Ekanem¹,

Eyong²,

Philip-Ephraim³

et al. 2014

Afr H. Sci.

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“…Preexposure rabies vaccines are routinely administered by three successive injections of inactivated vaccines. For rabies prevention in domestic and wild animals, live attenuated rabies vaccines (strain SAD-and ERA-based modified live rabies vaccines) and recombinant rabies vaccines based on vaccinia virus expressing RABV glycoprotein (G) (V-RG) have been developed (7)(8)(9). Despite the fact that these vaccines generated a good protective immune response in many species, poor protective immunities were observed in dogs and skunks (10)(11)(12).…”

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confidence: 99%

A Novel Rabies Vaccine Based on a Recombinant Parainfluenza Virus 5 Expressing Rabies Virus Glycoprotein

Chen

Zhou

Gao

et al. 2013

J Virol

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8 PFU of rPIV5-RV-G showed a 50% survival rate, which is comparable to the 60% survival rate among mice inoculated with an attenuated rabies vaccine strain, recombinant LBNSE. This is first report of an orally effective rabies vaccine candidate in animals based on PIV5 as a vector. These results indicate that rPIV5-RV-G is an excellent candidate for a new generation of recombinant rabies vaccine for humans and animals and PIV5 is a potential vector for oral vaccines.

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“…It causes more than 35,000 human deaths per year. 1 Successful application of veterinary vaccines can eliminate canine rabies in an area, but control of rabies in free-ranging carnivores requires other strategies, such as oral vaccination. 2 Live viral vaccines containing modified live rabies or recombinant vaccinia-rabies glycoprotein virus, placed in a bait, are used for disease control in Europe and North America.…”

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confidence: 99%