Rationale and Use of Corticosteroids in Chronic Obstructive Pulmonary Disease

Effects of anabolic steroids on diaphragm impairment induced by methylprednisolone in emphysematous hamsters

“…Indeed, in a previous study, administration of 0.2 mg·kg ‐1 ·day ‐1 MP for 6 months in normal rats caused a 10–15% reduction in diaphragm twitch and maximum tetanic force generation [8]. Although the therapeutic efficacy of glucocorticoids in COPD is controversial [5], prolonged prednisolone administration in doses of 10–15 mg daily are no exception in the treatment of patients. ND was administered in a dose used by others in clinical studies [7], and as recommended for use in patients by the manufacturer.…”

Oxidative Stress in Chronic Obstructive Pulmonary Disease

“…Additional approaches include nutritional supplementation, immuniza tion, breathing exercises, pulmonary rehabilitation, and ulti mately supplemental oxygen, given nocturnally or continu ously. Conventional therapies for COPD are discussed below, focusing on their potential effect on oxidant-antioxidant bal lt is still unclear whether inhaled corticosteroids attenuate COPD, even though several placebo-controlled clinical stud ies have addressed the question (249)(250)(251)(252)(253)(254)(255). However, steroids may have an antioxidant effect by decreasing the numbers as well as the oxidative and chemotactic responses of neutro phils.…”

The response to inhaled and oral steroids in patients with stable chronic obstructive pulmonary disease

“…The subjects' response to bronchodilators (increase in FEV 1 Ͼ 20% following inhalation of 5 mg of salbutamol administered by a Devilbiss no. 646 nebulizer) was determined first and they were categorized as: (1) responders to ␤ 2 -agonist-group A -each patient had at least 20% increase in FEV 1 following bronchodilators; (2) non-responders to ␤ 2 -agonist-group B -no patient had at least 20% increase in FEV 1 following bronchodilators.…”

“…Out (7) Out (12) Out (2) Out (2) Out ( Deterioration (1) Additional effect (1) No effect (8) Deterioration (1) Additional effect (0) No effect (7) Deterioration (1) Additional effect (4) No effect (85) Deterioration (6) Fig. 4 Mean inhaled ␤ 2 -agonist consumption before the study, and during the treatment period of either 800 or 1600 g day Ϫ1 of inhaled budesonide or prednisone.…”