Rationale, design and methodology of the EPIC (Epidemiology of Polypharmacy and potential drug-drug Interactions in elderly Cardiac outpatients) study

Özlek, Eda; Çekiç, Edip Güvenç; Özlek, Bülent; Çil, Cem; Çeli̇k, Oğuzhan; Doğan, Volkan; Başaran, Özcan; Tanık, Veysel Ozan; Özdemir, İbrahim Halil; Çelik, Yunus; Kaçmaz, Caner; Şimşek, Zeki; Güneş, Hacı Murat; Şafak, Özgen; Özkan, Bülent; Taşar, Onur; Önal, Çağatay; Bekar, Lütfü; Biteker, Murat

doi:10.5543/tkda.2019.27724

Cited by 3 publications

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“…As a result of the growing proportion of older adults in the general population and the prevalence of multiple chronic diseases, there are, among aged individuals, prescriptions for multiple medications that lead to drug interactions and polypharmacy 21 , defined as the regular use of five or more medications. Polypharmacy has the following consequences: greater demand for care in health services, greater number of hospitalization days and higher costs for the health system 22 .…”

Section: Discussionmentioning

confidence: 99%

Adherence and Barriers to Drug Therapy: Relationship With the Risk of Falls in Older Adults

Soares

Fukujima

Costa

et al. 2022

Texto contexto - enferm.

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Objective: to verify the association of adherence and barriers to drug therapy with the risk of falls and the sociodemographic, clinical and economic variables. Method: a cross-sectional study, carried out with 117 aged individuals in a Medical Clinic of Specialties for Older Adults in the Southeast region of the city of São Paulo (SP), from March to November 2019. The following scales were applied: Downton Fall Risk, Morisky-Green Test and Brief Medication Questionnaire. Logistic regression was use to verify the association between adherence to the treatment and types of barriers to adherence and the risk of falls. A 5% significance level was used. Results: the older adults with low adherence to the drug treatment presented 5.57 times more chances of having a high risk of falling when compared to those with greater adherence, and those with a barrier in the recall domain had 22.75 times more chances of having a high risk of falling, in relation to the aged individuals without barriers in the recall domain. Conclusion: low and average adherence to drug therapy and the barrier related to the recall domain were associated with high risk of falls in the older adults.

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Section: Discussionmentioning

confidence: 99%

Adherence and Barriers to Drug Therapy: Relationship With the Risk of Falls in Older Adults

Soares

Fukujima

Costa

et al. 2022

Texto contexto - enferm.

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Rationale, Design, and Methodology of the MORCOR-TURK Trial: Predictors of In-hospital MORtality in CORonary Care Patients in Turkey

et al. 2023

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Aging and Cardiovascular Diseases

Topuz,

Topuz

2024

JHS

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According to the World Health Organization, the term “elderly” refers to people over the age of 65. Decreases in heart rate, heart function, oxygen consumption and stroke rate occur with aging. Many changes occur in the cardiovascular system with aging, and this predisposes to diseases. The aim of this review article is to examine the physiological relationship between aging and cardiovascular diseases. Depending on genetic differences and age, the heart's ability to pump blood decreases, the myocardium loses flexibility, and the heart valves thicken and increase in diameter. Aging is an inevitable part of life and constitutes the most important risk factor for cardiovascular diseases. Arteriosclerosis increases the thickness of blood vessels while decreasing their elasticity. Functional and structural changes in the cardiovascular system in older ages increase the risk of coronary artery disease, heart diseases, heart failure, venous thrombosis, and hypertension. Cardiac output and stroke volume decreases and the risk of postural hypotension increases. With advancing age, a continuous rise in systolic blood pressure occurs as a result of a hardening of the vessels and their diminished elasticity. After the age of 60, either a slight decrease or no change is seen in diastolic blood pressure.

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Rationale, design and methodology of the EPIC (Epidemiology of Polypharmacy and potential drug-drug Interactions in elderly Cardiac outpatients) study

Cited by 3 publications

References 0 publications

Adherence and Barriers to Drug Therapy: Relationship With the Risk of Falls in Older Adults

Adherence and Barriers to Drug Therapy: Relationship With the Risk of Falls in Older Adults

Rationale, Design, and Methodology of the MORCOR-TURK Trial: Predictors of In-hospital MORtality in CORonary Care Patients in Turkey

Aging and Cardiovascular Diseases

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