Rationale design of unrestricted pRN1 derivatives and their application in construction of a dual plasmid vector system forSaccharolobus islandicus
Pengpeng Zhao,
Xiaonan Bi,
Xiaoning Wang
et al.
Abstract:Sulfolobus species belonging to crenarchaea code for a novel DNA damage response (DDR) system in which an Orc1/Cdc6 family protein, Orc1-2, initiates a global cellular response to DNA damage by functioning as a global transcriptional regulator. However, the mechanism that modulates Orc1-2 activity upon DNA damage remains unclear. In this study, we found that Sulfolobus islandicus Orc1-2 was phosphorylated under normal growth and non-phosphorylated upon DNA damage treatment at Thr356. Interestingly, the phospho… Show more
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