Rationale for a Minimum Number of Lymph Nodes Removed with Non-Small Cell Lung Cancer Resection: Correlating the Number of Nodes Removed with Survival in 98,970 Patients

Abstract

Survival of early-stage NSCLC patients is associated with the number of LNs removed. The surgical management of early-stage NSCLC should include thoracic lymphadenectomy of at least 10 nodes.

The lymph node status and histologic subtypes influenced the effect of postoperative radiotherapy on patients with N2 positive IIIA non–small cell lung cancer

“…Lymph nodes metastasis status was a strong predictor of both local control and OS for patients with NSCLC . The previous study in our institution has revealed that patients with pathologic single station N2 diseases could get favorable survival outcomes from upfront surgery followed by adjuvant therapy .…”

“…In 576 patients, 403 recurrence events were observed, in which distant recurrence accounted for 70% (282 events). The failure pattern was a major reason why no OS or RFS improvement was observed in IIIA-N2 cohort.Lymph nodes metastasis status was a strong predictor of both local control and OS for patients with NSCLC [22][23][24]. The previous study in our institution has revealed that patients with pathologic single station N2 diseases could get favorable survival outcomesF I G U R E 4 Kaplan-Meier survival curves of matched patients with different adenocarcinoma subtypes who received POCT.…”

Does surgery or radiation provide the best overall survival in Ewing's sarcoma? A review of the National Cancer Data Base

“…The NCDB captures treatment and outcomes data for 70% of new cancer diagnoses in the United States, serving as a valuable resource for researchers as well as those interested in quality control . Similar investigations have utilized the NCDB to report on survival after various forms of treatment in many malignancies . However, the NCDB has not been previously utilized to investigate the overall survival associated with various methods of local control in patients with Ewing's sarcoma.…”

Scientific Advances in Thoracic Oncology 2016

“…The benefit of thorough thoracic lymphadenectomy in early-stage NSCLC was further emphasized with multiple metaanalysis and population-based studies demonstrating improved OS when greater numbers of lymph nodes were resected and examined. [104][105][106][107][108] Adjuvant Therapy in Completely Resected NSCLC Section Authors: Heather Wakelee, MD, and Yi-Long Wu, MD…”