Rationale for adding trace elements to total parenteral nutrient solutions—a brief review

Odne, Mary Ann L.; Lee, Susan C.; Jeffrey, Louis P.

doi:10.1093/ajhp/35.9.1057

Cited by 2 publications

(1 citation statement)

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“…The first discussion of a specific biological function dependent on zinc came with the discovery in 1940 that zinc was essential to carbonic anhydrase's mechanism of action (6). Since then, zinc has proved to be an important constituent of more than 20 human metalloenzymes (9,19,20). Zinc is thought to act at the catalytic site, forming highly specific associations with metalloenzymes.…”

Section: Physiological Roles Of Zinc Metalloenzymesmentioning

confidence: 99%

Clinical Aspects of Trace Elements: Zinc in Human Nutrition – A Biochemical and Physiological Perspective

Pluhator

Thomson

Fedorak

1995

Canadian Journal of Gastroenterology and Hepatology

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The tremendous technological advances in trace element analysis seen in recent years have stimulated and facilitated research in a number of disciplines including microbiology, nutrition, agriculture, clinical medicine and, most recently, psychology. The importance of trace elements to human health is receiving greater attention as clinical cases of deficiency and toxicity are described. Zinc has been recognized as an essential trace element for humans since the early 1960s. It has been found to play a critical role in the physiological and biochemical well-being of humans. This review discusses the tissue distribution, concentration and intracellular binding of zinc in healthy humans. (Other reviews in this five-part series will appear in following issues.) The biochemical roles of zinc, including its involvement in the actions of metalloenzymes, cell synthesis, wound healing, growth, reproduction, hormone metabolism, cellular structural stability and immunological processes, are highlighted in order to provide an understanding of the unique and extensive role zinc plays in the biochemistry of the human body.

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