Rationale for and Results From a Randomised, Double-Blind Trial of Tetrachlorodecaoxygen Anion Complex in Wound Healing

J, Hinz; Hautzinger, H.; Stahl, Kurt-Wilhelm

doi:10.1016/s0140-6736(86)90939-6

Cited by 48 publications

(35 citation statements)

References 4 publications

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“…These indications have been studied extensively and reviewed [2]. Oxoferrin is used topically to enhance healing of chronic wounds such as diabetic ulcers [3]. The clinical uses of this drug have been expanding as new research has evolved regarding the mechanism of WF10's activity in regulating immunologic activation.…”

mentioning

confidence: 99%

Balanced Macrophage Activation Hypothesis: A Biological Model for Development of Drugs Targeted at Macrophage Functional States

McGrath

Kodelja²

1999

Pathobiology

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Macrophages play a central role in the immune response and are major targets for chronic infection with viruses such as HIV. Recent studies on macrophage differentiation have shown the existence of classical activation and the counter-balancing anti-inflammatory alternative activation states. In the ‘balanced macrophage activation hypothesis’ we propose that macrophage activation is a cyclic process that balances these two states to achieve proper immunologic function. Dysregulation of this cycle would, therefore, be associated with various forms of chronic disease. This model has been utilized in the drug development of WF10, a novel macrophage-targeted drug, currently in advanced clinical testing for the treatment of HIV disease.

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confidence: 99%

Balanced Macrophage Activation Hypothesis: A Biological Model for Development of Drugs Targeted at Macrophage Functional States

McGrath

Kodelja²

1999

Pathobiology

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“…It forms a TCDO-hemo complex with heme part ofhemoglobin, myoglobin and peroxidases. This mechanism in turn activates the macrophages and modulates the process of phagocytosis to engulf pathogens and cell debris which is present on the wound surface, thus cleansing of wound surface and regenerative process at wound site is accelerated [12]. There are many reports which indicate the use of these herbal products as wound healing agents, but their evaluation in comparison with some established wound healing agent have never been done, so keeping in view the economics the proposed study has been planned with the objectives; …”

Section: Introductionmentioning

confidence: 99%

Comparative Wound Healing Efficacy of Neem Oil, Turmeric and Oxoferin® On Full Thickness Cutaneous Wounds in a Rabbit Model

Shahbaz¹

2017

IOSR JAVS

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“…Initially, in its locally applicable form (Oxoferin®), it was described as an effective wound-healing agent [4,5]. In addition, skin necroses and chronic ulcers caused by extravasation of cytostatics could be prevented by topical application of TCDO [6].…”

Section: Introductionmentioning

confidence: 99%

Influence of Tetrachlorodecaoxide (Ryoxon®) on the Development of Leukemia after Total-Body Gamma-Irradiation

Kempf

Blaszkiewitz²,

Port³

et al. 1994

Oncology

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The effect of tetrachlorodecaoxide (TCDO) treatment after total-body irradiation (TBI) with γ-rays (single dose, about LD 50) on the development of radiation-induced leukemia was tested in rats. TCDO was applied intravenously from day 4 through day 11. The control group was exposed to the same dosage of X-rays (TBI), but received physiological saline solution instead of TCDO. Compared to the control group, TCDO therapy initially markedly increased the survival rate: 72 versus 44% (6 months after TBI) and 36 versus 20% (1-year survival rate). The overall survival, however, was not significantly prolonged. TBI caused leukemia in 36% of the rats in the irradiation control group without TCDO treatment, however, none of 24 rats treated with TCDO after X-ray exposure developed leukemia. Since in this study TCDO was only administered for 8 days during the acute phase of radiation syndrome, we suppose that additional TCDO treatment at various times later on would lead to even better results.

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Rationale for and Results From a Randomised, Double-Blind Trial of Tetrachlorodecaoxygen Anion Complex in Wound Healing

Cited by 48 publications

References 4 publications

Balanced Macrophage Activation Hypothesis: A Biological Model for Development of Drugs Targeted at Macrophage Functional States

Balanced Macrophage Activation Hypothesis: A Biological Model for Development of Drugs Targeted at Macrophage Functional States

Comparative Wound Healing Efficacy of Neem Oil, Turmeric and Oxoferin® On Full Thickness Cutaneous Wounds in a Rabbit Model

Influence of Tetrachlorodecaoxide (Ryoxon®) on the Development of Leukemia after Total-Body Gamma-Irradiation

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