Rationale for the use of radiolabelled peptides in diagnosis and therapy

Abstract

Nuclear medicine techniques are becoming more important in imaging oncological and infectious diseases. For metabolic imaging of these diseases, antibody and peptide imaging are currently used. In recent years peptide imaging has become important, therefore the rationale for the use of peptide imaging is described in this article. Criteria for a successful peptide tracer are a high target specificity, a high binding affinity, a long metabolic stability and a high target-to-background ratio. Tracer internalization is also beneficial. For oncological imaging, many tracers are available, most originating from regulatory peptides, but penetrating peptides are also being developed. Peptides for imaging inflammatory and infectious diseases include regulatory peptides, antimicrobial peptides and others. In conclusion, for the imaging of oncological, imflammatory and infectious diseases, many promising peptides are being developed. The ideal peptide probe is characterized by rapid and specific target localization and binding with a high tumour-to-background ratio.

Prospective of 68Ga-Radiopharmaceutical Development

“…G-protein and G-protein coupled receptor discoveries, both awarded with Nobel Prize, respectively in 1994 and 2012, provided basis for the important and most explored class of imaging agents comprising small regulatory peptides that are involved in many metabolic processes in almost all organs 41-43. It should be mentioned that one of the factors that tremendously contributed to the progress of 68 Ga applications was the advent of agonist somatostatin ligand analogue (DOTA-D-Phe 1 -Tyr 3 -Octreotide, (DOTA-TOC)).…”

“…RGS resulted in change in the operative procedure in 56%. In addition, overexpression of SSTR has been found in patients with inflammatory bowel diseases, pulmonary diseases, rheumatoid arthritis, Sjogren's syndrome, Grave's disease 43, 216.…”

Radiopeptides for Imaging and Therapy: A Radiant Future

“…(CXCR4) (1). Examples of radiopeptide families and their applications for tumor imaging and therapy are shown in Figure 1.…”

Advancement in treatment and diagnosis of pancreatic cancer with radiopharmaceuticals

“…Radiolabelled receptor-binding peptides have become important radiopharmaceuticals for diagnosis and therapy in tumor [57][58][59][60][61] .…”