Rationally Designed Circularly Arranged Sextuple Molecule with Dimethoxyphenolic Tentacles for Ample Hunting of Cyanide

Abstract

Herein, we report the design, synthesis, and cyanide-scavenging behavior of circularly arranged sextuple molecule 4. The six syringaldehyde units carrying equal number of dimethoxyphenolic moieties projecting at the periphery make the molecule highly efficient for cleaning up cyanide from the aqueous solution. The stoichiometric data 1:6 showed that six units of cyanide interact with one unit of compound 4. The association constant of the compound for cyanide was 2.5 × 10 4 M –1 , and its detection limit for cyanide was 10 nM. The compound was also found to remove cyanide bound to cytochrome c oxidase.

Synthesis of (E)‐3‐Alkylideneindolin‐2‐ones by an Iron‐Catalyzed Aerobic Oxidative Condensation of Csp3–H Bonds of Oxindoles and Benzylamines

“…Besides, many of the synthesized 3-alkylideneindolin-2-one compounds, namely (E)-3-benzylidene-7chloroindolin-2-one (3j), (E)-3-benzylidene-5-bromoindolin-2one (3k) and (E)-3-(4-methylbenzylidene)indolin-2-one (4a) are used as key precursors for the synthesis of bioactive molecules; [1a,18] and (E)-3-(3,4,5-trimethoxybenzylidene)indolin-2one (4g) is employed as precursor for the preparation of cyanide-scavenging material. [19] Scheme 4. Synthesis of pharmaceutically relevant (E)-3-alkylideneindolin-2one products.…”