Rationally designed dual functional block copolymers for bottlebrush-like coatings: In vitro and in vivo antimicrobial, antibiofilm, and antifouling properties

Gao, Qiang; Yu, Meng; Su, Yajuan; Xie, Meihua; Zhao, Xin; Li, Peng; Peter, X.

doi:10.1016/j.actbio.2017.01.061

Cited by 168 publications

(97 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accumulation of organic debris on the surface might lead to shielding of the active killing material (in particular for chemically functionalized surfaces), thereby reducing the bactericidal efficacy. Some attempts have hence been made to combine passive-defense antibacterial surfaces, which reduce the rate of bacteria sticking, with the bactericidal functionality [46,47].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Nanostructured Coatings: A Gas Phase Deposition and Magnetron Sputtering Perspective

et al. 2020

View full text Add to dashboard Cite

Counteracting the spreading of multi-drug-resistant pathogens, taking place through surface-mediated cross-contamination, is amongst the higher priorities in public health policies. For these reason an appropriate design of antimicrobial nanostructured coatings may allow to exploit different antimicrobial mechanisms pathways, to be specifically activated by tailoring the coatings composition and morphology. Furthermore, their mechanical properties are of the utmost importance in view of the antimicrobial surface durability. Indeed, the coating properties might be tuned differently according to the specific synthesis method. The present review focuses on nanoparticle based bactericidal coatings obtained via magneton-spattering and supersonic cluster beam deposition. The bacteria–NP interaction mechanisms are first reviewed, thus making clear the requirements that a nanoparticle-based film should meet in order to serve as a bactericidal coating. Paradigmatic examples of coatings, obtained by magnetron sputtering and supersonic cluster beam deposition, are discussed. The emphasis is on widening the bactericidal spectrum so as to be effective both against gram-positive and gram-negative bacteria, while ensuring a good adhesion to a variety of substrates and mechanical durability. It is discussed how this goal may be achieved combining different elements into the coating.

show abstract

Section: Introductionmentioning

confidence: 99%

Antimicrobial Nanostructured Coatings: A Gas Phase Deposition and Magnetron Sputtering Perspective

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Surface modification techniques such as block co-polymerization [26,27], covalent grafting of hydrophilic groups to surfaces [28], nanoparticle functionalization [29,30], atom transfer radical polymerization [31], Radio Frequency plasma deposition and modifications of surfaces have been used to fabricate surfaces showing antifouling properties. Kim et al modified nanofiltration thin film composite membranes to be more hydrophilic by a treatment with NH 3 plasma.…”

Section: Introductionmentioning

confidence: 99%

In-Situ Surface Modification of Terpinen-4-ol Plasma Polymers for Increased Antibacterial Activity

et al. 2020

View full text Add to dashboard Cite

Surface modification of thin films is often performed to enhance their properties. In this work, in situ modification of Terpinen-4-ol (T4) plasma polymer is carried out via simultaneous surface functionalization and nanoparticle immobilization. Terpinen-4-ol plasma polymers surface were decorated with a layer of ZnO nanoparticles in an oxygen plasma environment immediately after polymer deposition. A combination of hydrophilic modification and ZnO nanoparticle functionalization of the T4 polymer surface led to an enhancement in antibacterial properties by factor of 3 (from 0.75 to 0.25 CFU.mm−2). In addition, ZnO nanoparticle-modified coatings demonstrated improved UV absorbing characteristics in the region of 300–400 nm by 60% relative to unmodified coatings. The ZnO modified coatings were transparent in the visible region of 400–700 nm. The finding points towards the potential use of ZnO nanoparticle-modified T4 plasma polymers as optically transparent UV absorbing coatings.

show abstract

“…As shown in Figs and , PU‐2 had no effect or led to a modest increase in bacterial attachment compared to PU‐1, which means the small amount of EF in the material did not improve its anti‐adhesion properties. This result was not unexpected, as a fluorine‐containing material surface has been previously shown to support bacterial attachment . Researchers also found that polymer having a low fluorine content could not effectively inhibit benthic diatom adhesion .…”

Section: Resultsmentioning

confidence: 77%

“…However, biofouling of bacteria and proteins on PU surfaces is also found frequently which limits the application of PUs as indwelling biomaterials. Surface modification of PUs with hydrophilic poly(ethylene glycol), betaine or hydrophobic perfluorocarbon chains renders PUs with good antifouling activities . As typical multi‐blocked copolymers, microphase separation between the soft and hard blocks is a characteristic property for PUs which is known to relate to their good mechanical properties and biocompatibilities .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antifouling activities of fluorinated polyurethanes

Qiao

Yan

et al. 2019

Polymer International

View full text Add to dashboard Cite

A series of fluorinated polyurethanes (FPUs) with various contents of fluorinated chain extender (EF) and the same amount of poly(oxytetramethylene glycol) and diphenylmethanediisocyanate were synthesized to explore the relationship between the surface physicochemical properties and bulk microphase separation structures of these FPUs and their antifouling activities against model bacteria and platelets. The bulk microphase separation of FPUs increased with the amount of incorporated EF. It was found that the surfaces of all FPUs were saturated by a layer of fluorocarbon chains which resulted in similar chemical composition and wetting activities for the three kinds of FPUs. The FPUs with lower or similar microphase separation compared with non-fluorinated polyurethane chain-extended with 1,4-butanediol showed similar or even increased adhesion of bacteria and platelets. Notably, FPU with a higher degree of microphase separation than non-fluorinated polyurethane displayed excellent antifouling activities against both model bacteria and blood platelets. It is therefore concluded that the increased microphase separation of the FPUs results in enhanced antifouling properties.

show abstract

Rationally designed dual functional block copolymers for bottlebrush-like coatings: In vitro and in vivo antimicrobial, antibiofilm, and antifouling properties

Cited by 168 publications

References 59 publications

Antimicrobial Nanostructured Coatings: A Gas Phase Deposition and Magnetron Sputtering Perspective

Antimicrobial Nanostructured Coatings: A Gas Phase Deposition and Magnetron Sputtering Perspective

In-Situ Surface Modification of Terpinen-4-ol Plasma Polymers for Increased Antibacterial Activity

Synthesis and antifouling activities of fluorinated polyurethanes

Contact Info

Product

Resources

About