Rationally designed meta-implants: a combination of auxetic and conventional meta-biomaterials

Kolken, H.M.A.; Janbaz, Shahram; Leeflang, M.A.; Lietaert, Karel; Weinans, Harrie; Zadpoor, Amir A.

doi:10.1039/c7mh00699c

Cited by 267 publications

(163 citation statements)

References 21 publications

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“…Other potential applications of mechanical metamaterials which makes use of its topological flexibility, size effects, and material constituents includes the creation of architected thermal heat exchangers and insulators, photonic crystals with unique optical properties, phononic crystals with tailorable bandgaps for acoustic cloaking, battery electrodes with optimized topology for electron transport, electrochemical and mechanical properties, and bio‐scaffolds or meta‐biomaterials, which involves the rational design of an optimized combination of mechanical, mass transport and biological properties to enhance tissue regeneration . Recently, microlattices for tunable electromagnetic shielding has also been reported …”

Section: Utilizing Architecture Size Effect and Mechanismmentioning

confidence: 99%

“…Owing to the relieved pressure on the swelling area, the hierarchical design could potentially be used in skin grafts as well . Other recent progresses include a rationally‐designed hip implant (Figure d, e) which combines both auxetic (negative Poisson's ratio) and conventional honeycomb (positive Poisson's ratio) structures to decrease the probability of a bone implant interface failure by minimizing the chance of wear particles entering the enclosed space (Hoffman's criterion) and mechanically stimulating bone growth to enhance fixation . They made use of SLM to 3D print these hybrid meta‐implants with biomedical‐grade titanium alloy Ti6Al4V‐ELI.…”

Section: Typical Examples Of Mechanical Metamaterialsmentioning

confidence: 99%

“…c) 3D reconstruction of a laser scanning microscope (LSM) confocal image stack showing the culturing of Cardiomyocytes cultured in a fibronectin‐functionalized 3D scaffold . d), e) Hybrid metallic meta‐implants consisting of both auxetic (negative Poisson's ratio) and conventional (positive Poisson's ratio) 3D architectures manufactured using Selective Laser Melting (SLM) …”

Section: Typical Examples Of Mechanical Metamaterialsmentioning

confidence: 99%

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Mechanical Metamaterials and Their Engineering Applications

et al. 2019

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In the past decade, mechanical metamaterials have garnered increasing attention owing to its novel design principles which combine the concept of hierarchical architecture with material size effects at micro/nanoscale. This strategy is demonstrated to exhibit superior mechanical performance that allows us to colonize unexplored regions in the material property space, including ultrahigh strength-to-density ratios, extraordinary resilience, and energy absorption capabilities with brittle constituents. In the recent years, metamaterials with unprecedented mechanical behaviors such as negative Poisson's ratio, twisting under uniaxial forces, and negative thermal expansion are also realized. This paves a new pathway for a wide variety of multifunctional applications, for example, in energy storage, biomedical, acoustics, photonics, and thermal management. Herein, the fundamental scientific theories behind this class of novel metamaterials, along with their fabrication techniques and potential engineering applications beyond mechanics are reviewed. Explored examples include the recent progresses for both mechanical and functional applications. Finally, the current challenges and future developments in this emerging field is discussed as well.

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Section: Utilizing Architecture Size Effect and Mechanismmentioning

confidence: 99%

Section: Typical Examples Of Mechanical Metamaterialsmentioning

confidence: 99%

Section: Typical Examples Of Mechanical Metamaterialsmentioning

confidence: 99%

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Mechanical Metamaterials and Their Engineering Applications

et al. 2019

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“…74 These properties make PEO highly suitable for the modification of AM meta-biomaterials, that are currently under development and may in the future significantly improve the fixation of bone scaffolds and orthopedic implants. 75 Assigning antibacterial properties to these highly porous structures will be crucial to fight off IAI. Thus far, some studies have indicated that the enormous surface area of AM porous biomaterials allows for enhanced antibacterial performance of biofunctionalized implants bearing Ag NPs alone 8 or in combination with antibiotics.…”

Section: View Article Onlinementioning

confidence: 99%

Self-defending additively manufactured bone implants bearing silver and copper nanoparticles

et al. 2020

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“…For example, electromagnetic metamaterials can have a negative refractive index (which causes incident radiation to refract in the opposite direction to a conventional material) . Mechanical metamaterials can have a negative Poisson's ratio (where a material expands laterally as it is stretched longitudinally, rather than contracts) . Analogously, a biological metamaterial results in an unnatural biological response.…”

Section: Introductionmentioning

confidence: 99%

High‐Aspect‐Ratio Nanostructured Surfaces as Biological Metamaterials

et al. 2020

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Materials patterned with high‐aspect‐ratio nanostructures have features on similar length scales to cellular components. These surfaces are an extreme topography on the cellular level and have become useful tools for perturbing and sensing the cellular environment. Motivation comes from the ability of high‐aspect‐ratio nanostructures to deliver cargoes into cells and tissues, access the intracellular environment, and control cell behavior. These structures directly perturb cells' ability to sense and respond to external forces, influencing cell fate, and enabling new mechanistic studies. Through careful design of their nanoscale structure, these systems act as biological metamaterials, eliciting unusual biological responses. While predominantly used to interface eukaryotic cells, there is growing interest in nonanimal and prokaryotic cell interfacing. Both experimental and theoretical studies have attempted to develop a mechanistic understanding for the observed behaviors, predominantly focusing on the cell–nanostructure interface. This review considers how high‐aspect‐ratio nanostructured surfaces are used to both stimulate and sense biological systems.

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Rationally designed meta-implants: a combination of auxetic and conventional meta-biomaterials

Abstract: Rationally designed meta-implants were found to create compression along both of their contact lines with the surrounding bone, thereby decreasing the chance of bone–implant interface failure (Hoffman's criterion) and wear particle-induced osteolysis, and improving bone ingrowth.

Cited by 267 publications

References 21 publications

Mechanical Metamaterials and Their Engineering Applications

Mechanical Metamaterials and Their Engineering Applications

Self-defending additively manufactured bone implants bearing silver and copper nanoparticles

High‐Aspect‐Ratio Nanostructured Surfaces as Biological Metamaterials

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