Rationally designed mimics of antioxidant manganoenzymes: Role of structural features in the quest for catalysts with catalase and superoxide dismutase activity

Signorella, Sandra; Palopoli, Claudia; Ledesma, Gabriela N.

doi:10.1016/j.ccr.2018.03.005

Cited by 95 publications

(83 citation statements)

References 183 publications

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“…The progress in design and synthesis of low-molecular weight antioxidant catalysts as catalasemimics has been recently reviewed. 18 The Mn⋯Mn separation in these model compounds is usually around 3.0-3.7 Å, mimicking well the Mn-Mn distance in native enzymes. This di-Mn structure has been achieved by judicious ligand design.…”

Section: Introductionmentioning

confidence: 71%

Dinuclear manganese(iii) complexes with bioinspired coordination and variable linkers showing weak exchange effects: a synthetic, structural, spectroscopic and computation study

et al. 2019

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Section: Introductionmentioning

confidence: 71%

Dinuclear manganese(iii) complexes with bioinspired coordination and variable linkers showing weak exchange effects: a synthetic, structural, spectroscopic and computation study

et al. 2019

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“…Many synthetic biomimetics of catalase and peroxidase are being developed as potential therapeutic agents against cancer, Alzheimer's aging and inflammatory and heart diseases [15][16][17][18], and as efficient catalytic systems for the degradation of various pollutants and bleaching which can be applied for example in food, dairy and textile industries [19][20][21][22][23][24]. Recently, we synthesized and characterized a series of mononuclear transition metal complexes with [M II (L n ) 2 ] (M = Fe(II) [25], Mn(II) [26,27], Ni(II) [27], Co(II) [28] and Cu(II) [29], n = 1, 2 and 4-6), [Fe III (L n )Cl 2 ] [30], [Cu II (HL n )X 2 ] (X = ClO 4 , Cl, n = 1, 2 and 4-6)] [29] and [Mn II (HL 1 and 5 )Cl 2 ] [31,32] compositions, and used as biomimetics of superoxide dismutase (SOD) [27], catalase [26,31,32], phenoxazinone synthase, catechol oxidase [33] and dioxygenase [30] enzymes.…”

Section: Introductionmentioning

confidence: 99%

Design and Fine-Tuning Redox Potentials of Manganese(II) Complexes with Isoindoline-Based Ligands: H2O2 Oxidation and Oxidative Bleaching Performance in Aqueous Solution

Meena

Kaizer

2020

Catalysts

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A series of divalent manganese complexes [M II (HL 1-6 )Cl 2 ] with the 1,3-bis(2'-Ar-imino) isoindolines (HL n , n = 1-6, Ar = pyridyl, 4-methylpyridyl, imidazolyl, thiazolyl, benzimidazolyl and N-methylbenzimidazolyl, respectively) including the previously reported ligands (HL 1-2, 4-6 ) and complexes ([M II (HL 1,5 )Cl 2 ]) have been prepared and characterized by electrochemical and spectroscopic methods. In these complexes, it was possible to control the redox potential of the metal center by varying the aryl substituent on the bis-iminoisoindoline moiety, and investigate its effect in a catalase-like reaction, and oxidative bleaching process in buffered aqueous solution. The kinetics of the dismutation of H 2 O 2 into H 2 O and O 2 , and the oxidative degradation of morin by H 2 O 2 were investigated in buffered water, where the reactivity of the catalysts in both systems was markedly influenced by the redox and Lewis acidic properties of the metal centers and the concentration of the bicarbonate ions. Both the catalase-like and bleaching activity of the catalysts showed a linear correlation with the Mn III /Mn II redox potentials. The E 1/2 spans a 561 mV range from 388 mV (Ar = benzymidazolyl) to 948 mV (Ar = 4-methylpyridyl) vs. the SCE. The amount of bicarbonate is a critical issue for the in situ formation of peroxycarbonate as a versatile oxidant, and its participation in the formation of high valent Mn IV = O species.

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“…An enhanced DCF fluorescence intensity was observed in Glu-treated cells 5 Oxidative Medicine and Cellular Longevity declined. Superoxide dismutase (SOD) is an antioxidant metalloenzyme that specifically acts as a disproportionation catalyst to suppress superoxide anion radical generation [29]. As Figure 2(c) demonstrated, Glu severely inhibited activity of SOD in PC12 cells.…”

Section: Thvf Alleviated Oxidative Stress Caused By Glumentioning

confidence: 99%

Tetrastigma hemsleyanum Vine Flavone Ameliorates Glutamic Acid-Induced Neurotoxicity via MAPK Pathways

Chu

Zheng

et al. 2020

Oxidative Medicine and Cellular Longevity

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Glutamic acid (Glu) is a worldwide flavor enhancer with various positive effects. However, Glu-induced neurotoxicity has been reported less. Tetrastigma hemsleyanum (TH), a rare herbal plant in China, possesses high medicinal value. More studies paid attention to tuber of TH whereas vine part (THV) attracts fewer focus. In this study, we extracted and purified flavones from THV (THVF), and UPLC-TOF/MS showed THVF was consisted of 3-caffeoylquinic acid, 5-caffeoylquinic acid, quercetin-3-O-rutinoside, and kaempferol-3-O-rutinoside. In vitro, Glu caused severe cytotoxicity, genotoxicity, mitochondrial dysfunction, and oxidative damage to rat phaeochromocytoma (PC12) cells. Conversely, THVF attenuated Glu-induced toxicity via MAPK pathways. In vivo, the neurotoxicity triggered by Glu restrained the athletic ability in Caenorhabditis elegans (C. elegans). The treatment of THVF reversed the situation induced by Glu. In a word, Glu could cause neurotoxicity and THVF owns potential neuroprotective effects both in vitro and in vivo via MAPK pathways.

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Rationally designed mimics of antioxidant manganoenzymes: Role of structural features in the quest for catalysts with catalase and superoxide dismutase activity

Cited by 95 publications

References 183 publications

Dinuclear manganese(iii) complexes with bioinspired coordination and variable linkers showing weak exchange effects: a synthetic, structural, spectroscopic and computation study

Dinuclear manganese(iii) complexes with bioinspired coordination and variable linkers showing weak exchange effects: a synthetic, structural, spectroscopic and computation study

Design and Fine-Tuning Redox Potentials of Manganese(II) Complexes with Isoindoline-Based Ligands: H2O2 Oxidation and Oxidative Bleaching Performance in Aqueous Solution

Tetrastigma hemsleyanum Vine Flavone Ameliorates Glutamic Acid-Induced Neurotoxicity via MAPK Pathways

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