Ratlarda Methotrexate Kaynaklı Karaciğer Toksisitesine Karşı Silymarin ve Naringin’in Yararlı Etkileri

Çağlayan, Cüneyt

doi:10.17094/ataunivbd.347970

Cited by 5 publications

(1 citation statement)

References 11 publications

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“…Although there are many studies investigating the effects of plant extracts on healthy rats (Kandemir et al, 2017;Mercan et al, 2017;El Hendy and Al Gemeai, 2014;Oduola et al, 2010), no study has been found evaluating the effects of L. orientalis on the kidney and liver when oral administered. The most relevant study on this topic investigated the protective effects on different doses of L. orientalis oil on carbon tetrachloride (CCI4)-induced liver damage in rats, but were not evaluated effects on the livers of healthy rats (Aydýngöz et al, 2013).…”

Section: Kidneymentioning

confidence: 99%

Effects of Liquidambar Orientalis Oil on Liver and Kidneys in Heathy Wistar Rats

Kıyıcı,

Karaayvaz,

Akkan

et al. 2024

IJAR

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Background: Nowadays, the tendency towards alternative herbal therapies has increased due to the side effects of drugs. However, since the contents, method of use, dosage and toxic effects of herbal products are not fully known, undesirable situations are occasionally encountered. However, there are many experimental studies on the cytotoxicity of L. orientalis oil, most of these studies are in vivo modelling. In this study, the cytotoxic effects of L. orientalis oil on the liver and kidneys were investigated in healthy rats by oral administered. Methods: The study material consisted of 18 female Wistar albino rats (190-280 g) aged 8-10 weeks. All animals were housed under optimal temperature, light and humidity conditions and fed with normal rat pellet food ad libitum. Housing conditions were checked daily. Three groups were organized as L. orientalis oil, olive oil and control group, respectively. Each group consisted of 6 rats. L. orientalis oil group: L. orientalis oil (150 mg/kg) dissolved olive oil (0.6 mL). Olive oil group: Olive oil (0.6 mL). Control group: Empty gavage. The entire trial was performed by intragastric gavage once a day for 14 days. Result: The obtained data showed that serum biochemical parameters remained within normal ranges in oral use of Liquidambar orientalis oil (150 mg/kg) and did not show any difference with the control and olive oil groups. No pathological changes related to cytotoxicity were found in the samples taken from liver and kidney tissues.

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Section: Kidneymentioning

confidence: 99%

Effects of Liquidambar Orientalis Oil on Liver and Kidneys in Heathy Wistar Rats

Kıyıcı,

Karaayvaz,

Akkan

et al. 2024

IJAR

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Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy, and DNA damage

Çağlayan

Temel

Kandemir

et al. 2018

Environ Sci Pollut Res

166

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Cyclophosphamide (CP) is a common chemotherapeutic agent that is effective against a wide variety of tumors. The associated hepatotoxicity and nephrotoxicity, however, limit its therapeutic use. Naringin (NG) is a natural flavanone glycoside that has pharmacological and therapeutic activities, such as anti-inflammation, anti-apoptotic, and antioxidant properties. Therefore, the present study was undertaken to evaluate the protective effect of NG against CP-induced hepatotoxicity and nephrotoxicity in rats. Rats were pre-treated with NG (50 and 100 mg/kg b.w.) for 7 days before administering a single dose of CP (200 mg/kg b.w.) on the seventh day. CP-induced hepatotoxicity and nephrotoxicity were associated with an increase in serum toxicity markers and a decrease in antioxidant enzyme activities. CP also induced inflammatory responses by increasing the levels of tumor necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB), interleukin-6 (IL-6), and interleukin-1β (IL-1β), and activities of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, it activated the apoptotic and autophagic pathway by increasing cysteine aspartate-specific protease-3 (caspase-3) expression and light chain 3B (LC3B) level and also increased the expression of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is the marker of oxidative DNA damage. Pre-treatment with NG (50 and 100 mg/kg), however, significantly decreased serum toxicity markers, increased antioxidant enzyme activities, and regulated inflammation, apoptosis, autophagy, and oxidative DNA damage in hepatic and renal tissues. These results indicated that NG was an effective protectant against CP-induced hepatotoxicity and nephrotoxicity.

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Protective Effect of Hesperidin on Sodium Arsenite-Induced Nephrotoxicity and Hepatotoxicity in Rats

Türk

Kandemir

Yıldırım

et al. 2018

Biol Trace Elem Res

106

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The present study was conducted to investigate the protective effects of hesperidin (HSP) against sodium arsenite (SA)-induced nephrotoxicity and hepatotoxicity in rats. Thirty-five male Sprague Dawley rats were divided into five groups as follows: control, HSP, SA, SA + HSP 100, and SA + HSP 200. Rats were orally gavaged with SA (10 mg/kg body weight) and HSP (100 and 200 mg/kg body weight) for 15 days. SA increased oxidative damage by decreasing antioxidant enzyme activities, such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx), and glutathione (GSH) level and increasing malondialdehyde (MDA) level in the kidney and liver tissues. In addition, it increased serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and serum urea and creatinine levels. Furthermore, SA caused inflammation, apoptosis, and oxidative DNA damage by increasing tumor necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB), interleukin-1β (IL-1β), cysteine aspartate-specific protease-3 (caspase-3), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in the kidney and liver tissues and by increasing liver p53 and kidney interleukin-6 (IL-6) expressions. In other words, HSP administration reduced apoptosis, oxidative stress, inflammation, and oxidative DNA damage significantly in SA-induced kidney and liver tissues depending on dose. In this study, it was seen that HSP showed a protective effect against SA-induced kidney and liver toxicity.

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Ratlarda Methotrexate Kaynaklı Karaciğer Toksisitesine Karşı Silymarin ve Naringin’in Yararlı Etkileri

Cited by 5 publications

References 11 publications

Effects of Liquidambar Orientalis Oil on Liver and Kidneys in Heathy Wistar Rats

Effects of Liquidambar Orientalis Oil on Liver and Kidneys in Heathy Wistar Rats

Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy, and DNA damage

Protective Effect of Hesperidin on Sodium Arsenite-Induced Nephrotoxicity and Hepatotoxicity in Rats

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