Rats with a truncated ghrelin receptor (GHSR) do not respond to ghrelin, and show reduced intake of palatable, high-calorie food

Mackay, Harry A.; Charbonneau, Valerie R.; St-Onge, Veronique; Murray, E. Selkirk; Watts, A.; Wellman, Martin; Abizaid, Alfonso

doi:10.1016/j.physbeh.2016.04.048

Cited by 23 publications

(21 citation statements)

References 66 publications

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“…Thus, although the importance of GHSR activity for enhancing food reward (Valdivia et al, 2014(Valdivia et al, , 2015MacKay et al, 2016;Chuang et al, 2011) through its interaction with DA cells in the VTA, which enhances DA output in the NAc (Abizaid et al, 2006) is well established, it does not seem to be necessary for the expression of bingeing on a high-fat diet under the current experimental paradigm.…”

Section: Chow Intake On Non-access Daysmentioning

confidence: 77%

“…Conversely, blocking ghrelin in the VTA using a selective GHSR antagonist, BIM28163, blunted peripherally induced ghrelin food intake, reflecting less of an interest in food (Abizaid et al, 2006). More recent work from our lab has shown that rats with a truncated GHSR gene (GHSR m1/Mcwi ) demonstrate reduced food anticipatory activity as well as reduced "dessert" consumption while satiated, which could reflect disrupted reward system functioning (MacKay et al, 2016).…”

Section: Ghrelin and Dopamine In The Regulation Of Food Rewardmentioning

confidence: 99%

“…Conversely, rodents lacking GHSR show deficits in food reward behaviours (Chuang et al, 2011;Perello et al, 2011;King et al, 2016;MacKay et al, 2016). GHSRs are found in the VTA of rats and mice (Guan et al, 1997;Zigman et al, 2006) and approximately 60% colocalize with cells expressing tyrosine hydroxylase (TH; Abizaid et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies from our lab have also demonstrated the importance of intact ghrelin signaling in palatable food intake in rodents. Rats with a truncated ghrelin receptor (FHH-GHSR m1/Mcwi ) show reduced intake of a palatable and energy-dense "dessert" when satiated, relative to WT rats (MacKay et al, 2016). GHSR signaling is also important in developing a conditioned place preference (CPP) for HFD in food restricted mice (Perello et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Investigating the Role of the Growth Hormone Secretagogue Receptor in Food-Motivated Behaviours

King¹

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Section: Chow Intake On Non-access Daysmentioning

confidence: 77%

Section: Ghrelin and Dopamine In The Regulation Of Food Rewardmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigating the Role of the Growth Hormone Secretagogue Receptor in Food-Motivated Behaviours

King¹

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“…Ghrelin administration also increases preference for palatable foods such as those high in fat and/or sugar, whereas mice with a genetic mutation of the GHSR as well as those treated systemically with a GHSR antagonist show a decrease in preference for palatable food (Disse et al, 2010;Egecioglu et al, 2010;Perello et al, 2010;King et al, 2011;MacKay et al, 2016). Moreover, both fasted and sated mice show increased palatable food seeking behavior after exogenous ghrelin administration even in a novel environment (Lockie et al, 2017).…”

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confidence: 99%

Stranger Danger! The Role of Ghrelin in Modulation of Social Behavior

Park¹

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Ghrelin is a gut-derived peptide hormone associated with feeding, energy balance, reward and the stress response. Among many of its identified functions, the role of ghrelin in anxiety has been particularly controversial with some authors reporting anxiogenic and others reporting anxiolytic effects of ghrelin receptor activity. In this thesis, we demonstrated that increasing ghrelin receptor activity in mice has anxiolytic effects in tests of anxiety involving stimuli with positive incentive value (i.e. palatable food or a novel conspecific mouse). We also found that this anxiolytic effect is mediated, at least in part, by ghrelin receptors in the ventral tegmental area. A role for ghrelin in social anxiety is particularly intriguing because social withdrawal and social anxiety are common symptoms of depression and there is strong evidence that ghrelin has other antidepressant properties. Depressive-like behaviors can be generated in mice by psychosocial stressors such as chronic social defeat. Thus we explored the possibility that treatment with the ghrelin agonist GHRP6 could prevent and/or alleviate stress-induced social anxiety when administered alone or in combination with the commonly prescribed antidepressant citalopram. We found that peripheral GHRP6 treatment was not sufficient to prevent or treat social withdrawal induced by chronic stress exposure. Chronic GHRP6 treatment, however, increased the number of immature neurons in the hippocampus.Furthermore, we found that chronic GHRP6 treatment reduced weight gain when administered alone as well as in combination with citalopram. Weight gain is a common side effect of antidepressant treatment thus the finding that GHRP6 can reduce these metabolic side effects has potential therapeutic potential.3.

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Preclinical evidence for the addiction potential of highly palatable foods: Current developments related to maternal influence

et al. 2017

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Rats with a truncated ghrelin receptor (GHSR) do not respond to ghrelin, and show reduced intake of palatable, high-calorie food

Cited by 23 publications

References 66 publications

Investigating the Role of the Growth Hormone Secretagogue Receptor in Food-Motivated Behaviours

Investigating the Role of the Growth Hormone Secretagogue Receptor in Food-Motivated Behaviours

Stranger Danger! The Role of Ghrelin in Modulation of Social Behavior

Preclinical evidence for the addiction potential of highly palatable foods: Current developments related to maternal influence

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