Rats with differential self-grooming expression in the elevated plus-maze do not differ in anxiety-related behaviors

Reimer, Adriano E.; Oliveira, Amanda Ribeiro de; Diniz, Juliana Belo; Hoexter, Marcelo Q.; Chiavegatto, Silvana; Brandão, Marcus Lira

doi:10.1016/j.bbr.2015.06.036

Cited by 29 publications

(17 citation statements)

References 67 publications

(81 reference statements)

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“…The EPM used was similar to that described in previous studies (Daniels et al, 2004;Walf and Frye, 2007;Reimer et al, 2015). It consists of four arms (two open without walls and two enclosed by 15.25 cm high walls) 50 cm long and 5 cm wide.…”

Section: The Elevated Plus-maze (Epm)mentioning

confidence: 99%

Anti‐parkinsonian effects of fluvoxamine maleate in maternally separated rats

Dallé¹,

Daniels²,

Mabandla³

2016

Intl J of Devlp Neuroscience

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Exposure to early life stress has been shown to result in anxiety-like symptoms and exacerbates degeneration of dopaminergic neurons in a rat model of Parkinson's disease (PD). First line treatment for anxiety disorders includes the use of Fluvoxamine maleate (FM). In this study, we investigated whether treating anxiety-like symptoms with FM has an effect in alleviating the neurotoxic effects of 6-OHDA in a parkinsonian rat model. Early maternal separation was used to create a rat model that depicts anxiety-like symptoms. Maternally separated adult Sprague-Dawley rats were treated with FM prior to and following lesion with 6-hydroxydopamine (6-OHDA). The elevated plus-maze (EPM) and the forelimb akinesia tests were used to evaluate anxiety-like symptoms and motor impairment respectively. Blood plasma was used to measure corticosterone concentration, and striatal tissue was collected for dopamine (DA) and serotonin (5-HT) analysis. Our results show that animals exposed to early life stress displayed increased anxiety-like symptoms and elevated basal plasma corticosterone concentration which were attenuated by treatment with FM. A 6-OHDA lesion effect was evidenced by impairment in the forelimb akinesia test as well as decreased DA and 5-HT concentrations in the lesioned striatum. These effects were attenuated on DA neurons by FM treatment in the pre-lesion treated as opposed to the post-lesion treated rats. This study suggests that early treatment of anxiety-like behavior decreases the vulnerability of DA neurons to neurotoxic insults later in life thus slowing down DA degeneration in PD.

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Section: The Elevated Plus-maze (Epm)mentioning

confidence: 99%

Anti‐parkinsonian effects of fluvoxamine maleate in maternally separated rats

Dallé¹,

Daniels²,

Mabandla³

2016

Intl J of Devlp Neuroscience

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“…Rat subcohorts selected on the basis of self-grooming duration show no differences in anxiety-like behaviours or neurochemical and neuroendocrine parameters 5 …”

mentioning

confidence: 95%

“…For example, high-frequency, short bouts of self-grooming can yield a cumulative duration that is similar to that of fewer, longer bouts of such behaviour. Moreover, rats that exhibit different self-grooming durations may show no differences in anxiety-related behavioural or neuroendocrine parameters 5 . In addition, as self-grooming frequency (the rate of initiation) and bout length (execution) under stress probably have differential neural underpinnings, these aspects of self-grooming may differentially change during stress (BOX 1).…”

mentioning

confidence: 99%

'Stressing' rodent self-grooming for neuroscience research

2016

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“…The work by Begemann and colleagues 3 suggests that childhood trauma may partially explain the association between hallucinatory experiences and measures of executive function and working memory, but also that childhood trauma is of no explanatory value in terms of the verbal and general knowledge deficits associated with psychotic features. Similarly, the work by Aas and colleagues 4 suggests that childhood trauma is associated with deficits in general, but not specific, cognitive domains. Indeed, in our sample, we found only negligible, statistically nonsignificant correlations between childhood trauma and cognition.…”

Section: Childhood Trauma As a Neglected Factor In Psychotic Experienmentioning

confidence: 93%

Childhood Trauma as a Neglected Factor in Psychotic Experiences and Cognitive Functioning

Begemann

Sommer

2016

JAMA Psychiatry

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of inherent limitations, detailed in our publication, cautious interpretation of the findings is suggested.In this context, use of estrogen-based therapies for prevention or treatment of postmenopausal depression in the general population, on the basis of our findings, was clearly not recommended. This option is precluded owing to known adverse effects of currently available hormone therapy regimens and uncertainties regarding appropriate combination of estrogens and progestogens in postmenopausal women with intact uterus. However, owing to its potential clinical implication, we considered of interest and accordingly highlighted, the 2-fold increased depression risk of women with premature ovarian insufficiency (menopause at <40 years). These women represent only 1% of the female population but comprise a high-risk group for additional postmenopausal diseases; therefore, they deserve to be appropriately followed up for early recognition and evaluation of depressive symptoms. Hormone therapy has been recommended for treatment of estrogen deficiency symptoms in this group, 5 albeit its effect on preventing depression should be explored following our findings. All in all, our meta-analysis points to novel research questions regarding the effect of the cumulative lifetime sex hormone exposure on nervous system and mental health and the sustained neuroprotective and antidepressive properties of estrogens or progesterone.

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Rats with differential self-grooming expression in the elevated plus-maze do not differ in anxiety-related behaviors

Cited by 29 publications

References 67 publications

Anti‐parkinsonian effects of fluvoxamine maleate in maternally separated rats

Anti‐parkinsonian effects of fluvoxamine maleate in maternally separated rats

'Stressing' rodent self-grooming for neuroscience research

Childhood Trauma as a Neglected Factor in Psychotic Experiences and Cognitive Functioning

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