Rats with scopolamine- or MK-801-induced spatial discrimination deficits in the cone field task: animal models for impaired spatial orientation performance

Bouger, Pascale; Staay, Franz Josef van der

doi:10.1016/j.euroneuro.2004.11.006

Cited by 23 publications

(27 citation statements)

References 83 publications

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“…It is thought that these deficits can be at least partly modeled by the administration of scopolamine to normal adult animals [21] . In the current study, PGS32 at dosages of 0.125 and 2 mg/kg improved scopolamineinduced spatial cognitive deficits.…”

Section: Discussionmentioning

confidence: 99%

Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory

Xue

Yuan

et al. 2009

Acta Pharmacol Sin

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Aim: The aim of this study was to investigate the cognition-enhancing activity and underlying mechanisms of a triterpenoid saponin (polygalasaponin XXXII, PGS32) isolated from the roots of Polygala tenuifolia Willd. Methods: The Morris water maze was used to evaluate the spatial learning and memory of mice. To detect the basic properties of synaptic transmission and long-term potentiation (LTP) in the dentate gyrus of rats, electrophysiological recordings were made of evoked potentials. Western blotting analysis and immunofluorescence assays were used to determine the phosphorylation of extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB), synapsin I and the expression of brain derived neurotrophic factor (BDNF). Results: When administered at 0.125, 0.5, or 2 mg/kg, PGS32 could significantly prevent scopolamine-induced cognitive impairments in mice. Intracerebroventricular (icv) administration of PGS32 greatly enhanced basic synaptic transmission in the dentate gyrus of rats and induced LTP. In primary hippocampal neurons, as well as in the hippocampus of maze-trained mice, PGS32 activated the mitogen-activated protein (MAP) kinase cascade by promoting phosphorylation of ERK, CREB and synapsin I. The expression of BDNF was also greatly enhanced in the hippocampus. Conclusion: Our findings suggest that PGS32 can improve hippocampus-dependent learning and memory, possibly through improvement of synaptic transmission, activation of the MAP kinase cascade and enhancement of the level of BDNF. Therefore, PGS32 shows promise as a potential cognition-enhancing therapeutic drug.

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Section: Discussionmentioning

confidence: 99%

Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory

Xue

Yuan

et al. 2009

Acta Pharmacol Sin

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“…Spatial WM and RM capabilities have been measured in the cone-field task under various conditions (van der Staay et al, , 1990Bouger and van der Staay, 2005). This task has been found to be sensitive to transection of the fimbria that caused pronounced cholinergic denervation, predominantly of the more ventral pole of the hippocampus, as indicated by reduced AChE histochemistry .…”

Section: Discussionmentioning

confidence: 99%

“…This measure could range from 1 (completely different sequence) to 4 (identical sequence of all four food-reinforced visits). The measure reflects the variability of the pattern of cone visits, but it neglects all erroneous choices (van der Staay et al, 1986van der Staay, 1999;Bouger and van der Staay, 2005);…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Infrared photocells detected whether a rat poked its nose into a food cup (for details see Fig. 2 in Bouger and van der Staay, 2005).…”

Section: Apparatusmentioning

confidence: 99%

“…Rats are unable to discriminate between baited and unbaited cones by olfactory cues (cf. Willner et al, 1986;van der Staay et al, 1990;Bouger and van der Staay, 2005). One 45 mg food pellet was available in each baited cone as a reward.…”

Section: Apparatusmentioning

confidence: 99%

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Long‐term effects of immunotoxic cholinergic lesions in the septum on acquisition of the cone‐field task and noncognitive measures in rats

et al. 2006

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In rats, nonspecific mechanical or neurotoxic lesions of the septum impair spatial memory in, e.g., Morris water- and radial-maze tasks. Unfortunately, the lack of specificity of such lesions limits inferences about the role of the cholinergic hippocampal projections in spatial cognition. We therefore tested the effects of septal lesions produced by 192 IgG-saporin in rats, which is highly selective for basal forebrain cholinergic neurons, on home cage activity, noncognitive tests (modified Irwin test, open field and forced swimming tests, and various sensorimotor tasks), and the cone-field spatial learning task. The immunotoxic lesion reduced acetylcholine (ACh) levels in the septum (-61%) and hippocampus (>-75%). Rats with lesions showed mild home-cage hyperactivity at 4 weeks postlesion, but no noncognitive deficits at 13 weeks postsurgery. In the cone-field task, rats with septal lesions made more working- and reference-memory errors than the controls, but acquisition curves were parallel in both groups. The speed of visiting cones was faster in the rats with lesions, indicative of disturbed attention or increased motivation. These data support the growing evidence that involvement of the septohippocampal cholinergic system in spatial learning and memory may have been overestimated in studies that used lesions with poor selectivity.

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Zebrafish: An Animal Model to Study Nicotinic Drugs on Spatial Memory and Visual Attention

Ponzoni

Sala

Braida

2016

Nicotinic Acetylcholine Receptor Technologies

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Rats with scopolamine- or MK-801-induced spatial discrimination deficits in the cone field task: animal models for impaired spatial orientation performance

Cited by 23 publications

References 83 publications

Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory

Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory

Long‐term effects of immunotoxic cholinergic lesions in the septum on acquisition of the cone‐field task and noncognitive measures in rats

Zebrafish: An Animal Model to Study Nicotinic Drugs on Spatial Memory and Visual Attention

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