Rawls, Hume, and Original Contract

HE DEVELOPMENT OF CURAtive therapy for most pediatric malignancies provides the opportunity to investigate the impact of cancer treatment on health status of large numbers of long-term survivors. Numerous studies have established that cancer and its treatment predispose to late morbidity and increase the risk of early mortality in longterm childhood cancer survivors. 1-8 In general, children with aggressive tumor histologies have required more intensive treatment, which predispose them to heightened risks of physical morbidity. Treatment-related late sequelae with significant potential impact on physical functioning include neurocognitive dysfunction, cardiopulmonary toxicity, endocrinopathy, and second malignancy. The frequency and severity of many of the common sequelae have been correlated with sex, age at diagnosis, and cumulative dose-exposures of specific treatment modalities. 9-12

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Health Status of Adult Long-term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

Hudson¹

2003

JAMA: The Journal of the American Medical Association

728

591

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Trends and advances in cancer survivorship research: challenge and opportunity

Aziz

Rowland

2003

Seminars in Radiation Oncology

303

195

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The prevalence of hearing loss in children and adolescents with cancer

Silva¹,

Latorre

Cristófani

et al. 2007

Brazilian Journal of Otorhinolaryngology

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The treatment of cancer in children has several side effects, including ototoxicity. Inner ear structures may be affected and hearing loss may ensue. Aim: To estimate the prevalence of hearing loss in patients with cancer using the American Speech-Language-Hearing Association (ASHA), the Pediatric Oncology Group Toxicity (POGT), and the Bilateral Hearing Loss (PAB) criteria. Study design: a prospective study. Material and Methods: 94 patients admitted between 2003 and 2004 were analyzed. Visual inspection of the external auditory meatus and an audiologic evaluation were done. Descriptive statistics was used to characterize the sample, and Kappa statistics was used to investigate concordance of hearing loss in the three types of classification. Results: The prevalence of hearing loss was 42.5% using ASHA, 40.4% using POGT, and 12.8% using PAB. The concordance of hearing loss was weak for POGT and PAB (k=0.36) and for PAB and ASHA (k=0.33). The concordance between ASHA and POGT was almost perfect (k=0.96). Conclusions: Hearing loss is an important side effect of the treatment of cancer in children. Periodic audiology monitoring is recommended to detect early hearing loss and to revise the treatment if necessary. Adoption of a classification system that detects mild hearing loss (ASHA) is recommended.

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Rawls, Hume, and Original Contract

Cited by 13 publications

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Health Status of Adult Long-term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

Health Status of Adult Long-term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

Trends and advances in cancer survivorship research: challenge and opportunity

The prevalence of hearing loss in children and adolescents with cancer

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