Raynaud’s phenomenon — the clinical picture, treatment and diagnostics

Walecka, Irena; Malewska, Aleksandra; Roszkiewicz, Marek; Wieczorek, Marta; Lagun, Zuzanna; Szymańska, Elżbieta

doi:10.5603/aa.2017.0003

Cited by 2 publications

(3 citation statements)

References 16 publications

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“…Having a very distinctive triphasic clinical pattern, including sudden pallor of the fingers, followed by a cyanotic phase and ending with redness due to reactive hyperemia, it remains one of the most common symptoms in rheumatic diseases. The pathophysiology of RP, however, is a highly complex mechanism of neurogenic, inflammatory and immune responses [ 2 ]. Very promising research, such as its association with the release of Endothelin-1 and nitric oxide [ 3 , 4 ], facilitates a better understanding of the pathophysiology of RP (Fig.…”

Section: Introductionmentioning

confidence: 99%

The effect of vitamin D3 and thyroid hormones on the capillaroscopy-confirmed microangiopathy in pediatric patients with a suspicion of systemic connective tissue disease-a single-center experience with Raynaud phenomenon

2021

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Raynaud phenomenon (RP) may be the first manifestation of a systemic connective tissue disease (SCTD). Early detection of dysfunction of small vessels called microangiopathy is essential for the diagnostic process. The focus of this single-center, retrospective study was to investigate the potential dependencies between microvascular image and laboratory markers measured in children with RP. The study analyzed the nail-fold video-capillaroscopy (NVC) findings and laboratory results of 81 children between the ages 6 and 17 who were referred to pediatric rheumatologist with a suspicion of SCTD. Out of 52 patients presenting with RP at the time of evaluation, abnormalities in capillary microscopic imaging were found in 34. NVC findings were then compared to levels of specific biomarkers in serum. Vitamin D3 serum levels have been significantly decreased in patients with RP (23.4 ng/mL ± 8.76 vs. 30.0 ng/mL ± 12.66, P = 0.0148). There were positive significant correlations between levels of vitamin D3 and acute-phase reactants in serum, such as C-reactive protein ( P = 0.0292). Furthermore, free thyroxine levels (fT4) in patients with both RP ( P = 0.0126) and micro-angiopathy ( P = 0.05496) persisted in the lower range of the normal limit (< 1.0 ng/dL). Regular oral supplementation of vitamin D3 should be always considered in children with RP if deficiency is found. Additionally, low fT4 level (< 1.0 ng/dL) should be considered as an indication to perform NVC in patients suspected of SCTD even when they do not present RP.

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Section: Introductionmentioning

confidence: 99%

The effect of vitamin D3 and thyroid hormones on the capillaroscopy-confirmed microangiopathy in pediatric patients with a suspicion of systemic connective tissue disease-a single-center experience with Raynaud phenomenon

2021

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“…Laboratory findings showed an accelerated sedimentation rate, hypokaliemia and hyperglicemia. A previous capillaroscopy of the fingers revealed a late phase of scleroderma pattern-an irregular enlargement of vascular loops, lack of hemorrhages and severe capillary atrophy of the avascular regions of the nail bed [6].…”

Section: Case Reportmentioning

confidence: 99%

“…The most common finding in patients with SSc is Raynaud's phenomenon, a sudden paling of distal parts of the body, followed by cyanosis and further occurrence of erythema in the last stage [6].…”

Section: Introductionmentioning

confidence: 99%

Successful Intensification of Intravenous Rheological Treatment of Phalanges Ischemia in SSc Patient Using Alprostadil

Walecka¹,

Malewska²,

Lagun³

et al. 2017

J Cardiovasc Dis Diagn

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Systemic sclerosis (SSc) is a rare, auto immunological, connective tissue disease characterized by vasomotor disturbances, fibrosis and further atrophy of the skin and internal organs. There are many factors leading to immunological and vascular changes. One of the most prominent vascular symptoms is Raynaud's phenomenon, which may be caused by different factors such as cold or excessive stress. This case report presents a 37-year old Caucasian woman with SSc, with severely impaired microcirculation of the hands and necrosis of the distal phalanges due to several hours of exposure to the cold. The patient required intensification of intravenous rheological treatment with alprostadil and oral usage of sildenafil, which had a positive effect on the improvement of the impaired microcirculation. Like many others, this case demonstrates that IV. rheological treatment may be effective in restoring microcirculation in such cases among SSc patients.

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Raynaud’s phenomenon — the clinical picture, treatment and diagnostics

Abstract: Raynaud

Cited by 2 publications

References 16 publications

The effect of vitamin D3 and thyroid hormones on the capillaroscopy-confirmed microangiopathy in pediatric patients with a suspicion of systemic connective tissue disease-a single-center experience with Raynaud phenomenon

The effect of vitamin D3 and thyroid hormones on the capillaroscopy-confirmed microangiopathy in pediatric patients with a suspicion of systemic connective tissue disease-a single-center experience with Raynaud phenomenon

Successful Intensification of Intravenous Rheological Treatment of Phalanges Ischemia in SSc Patient Using Alprostadil

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