Rays of Positive Electricity and their Application to Chemical Analysis

Thomson, J. J.

doi:10.1259/jrs.1914.0021

Cited by 42 publications

(50 citation statements)

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“…It occurred, however, in a timeframe of milliseconds within the mass spectrometry equipment. Ion-molecule reactions within mass spectrometry are old phenomena that were first noticed as early as 1913 [25]. They are mainly observed and monitored within ion trap (IT) mass analyzers (quadrupole IT and Fourier Transform MS) [26 -29].…”

Section: Discussionmentioning

confidence: 99%

Establishment of mass spectrometric fingerprints of novel synthetic cholesteryl neoglycolipids: The presence of a unique C-glycoside species during electrospray ionization and during collision-induced dissociation tandem mass spectrometry

El‐Aneed

Banoub

Koen‐Alonso

et al. 2007

J. Am. Soc. Mass Spectrom.

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In this study we evaluated the fragmentation pattern of 16 novel amphiphilic neoglycolipid cholesteryl derivatives that can be efficiently used to increase cationic liposomal stability and to enhance gene transfer ability. These neoglycolipids bear different sugar moieties, such as D-glucosamine, In addition, we observed a unique ion that could not be rationally explained by the expected fragmentation of these amphiphilic molecules. The structure of this ion was tentatively proposed with that of a C-glycoside species formed by a chemical reaction between the sugar portion and the cholesterol. MS/MS analysis of this unique [C-glycoside] ϩ confirmed the validity of the proposed structure of this ion. The presence of an amino group at position C-2 and free hydroxyl groups of the sugar motif is crucial for the formation of a "reactive" sugar oxonium ion that can form the [C-glycoside] ϩ species. In summary, we precisely established the fragmentation patterns of the tested series of neoglycolipid cholesteryl derivatives and authenticated their structure as well; moreover, we speculated on the formation of a C-glycoside with the ESI source under atmospheric pressure and in the collision cell during MS/MS analysis. (J Am Soc Mass Spectrom 2007, 18, 294 -310)

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Section: Discussionmentioning

confidence: 99%

Establishment of mass spectrometric fingerprints of novel synthetic cholesteryl neoglycolipids: The presence of a unique C-glycoside species during electrospray ionization and during collision-induced dissociation tandem mass spectrometry

El‐Aneed

Banoub

Koen‐Alonso

et al. 2007

J. Am. Soc. Mass Spectrom.

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“…When J. J. Thomson described his first mass spectrometry instrument almost a century ago [30], he predicted that the measured masses of a molecule and its fragments would provide uniquely valuable structural information, e.g., the masses 12, 16, and 28 for carbon monoxide. The basic idea of top-down MS was also established more than a half century ago for electron ionization mass spectra, and this application has been extensively developed [31].…”

Section: Origins Of Top-down Mass Spectrometrymentioning

confidence: 99%

Top-down identification and characterization of biomolecules by mass spectrometry

Breuker

Jin

Han

et al. 2008

J. Am. Soc. Mass Spectrom.

112

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The most widely used modern mass spectrometers face severe performance limitations with molecules larger than a few kDa. For far larger biomolecules, a common practice has been to break these up chemically or enzymatically into fragments that are sufficiently small for the instrumentation available. With its many sophisticated recent enhancements, this "bottom-up" approach has proved highly valuable, such as for the rapid, routine identification and quantitation of DNA-predicted proteins in complex mixtures. Characterization of smaller molecules, however, has always measured the mass of the molecule and then that of its fragments. This "top-down" approach has been made possible for direct analysis of large biomolecules by the uniquely high (>10 5 ) mass resolving power and accuracy (~1 ppm) of the Fourier-transform mass spectrometer. For complex mixtures, isolation of a single component's molecular ions for MS/MS not only gives biomolecule identifications of far higher reliability, but directly characterizes sequence errors and posttranslational modifications. Protein sizes amenable for current MS/MS instrumentation are increased by a "middle-down" approach in which limited proteolysis forms large (e.g., 10 kDa) polypeptides that are then subjected to the top-down approach, or by "prefolding dissociation". The latter, which extends characterization to proteins >200 kDa, was made possible by greater understanding of how molecular ion tertiary structure evolves in the gas phase.

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“…Nevertheless, they are not a recent invention. The first mass spectrometer was built beginning in 1905 (Thomson, 1913). More complex instruments were built shortly thereafter (Dempster, 1918;Aston, 1919).…”

Section: A Introductionmentioning

confidence: 99%

Stable isotopes in obesity research

Dolnikowski

Marsh

Das

et al. 2004

Mass Spectrometry Reviews

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Obesity is recognized as a major public health problem. Obesity is a multifactorial disease and is often associated with a wide range of comorbidities including hypertension, non-insulin dependent (Type II) diabetes mellitus, and cardiovascular disease, all of which contribute to morbidity and mortality. This review deals with stable isotope mass spectrometric methods and the application of stable isotopes to metabolic studies of obesity. Body composition and total energy expenditure (TEE) can be measured by mass spectrometry using stable isotope labeled water, and the metabolism of protein, lipid, and carbohydrate can be measured using appropriate labeled tracer molecules.

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Rays of Positive Electricity and their Application to Chemical Analysis

Cited by 42 publications

References 0 publications

Establishment of mass spectrometric fingerprints of novel synthetic cholesteryl neoglycolipids: The presence of a unique C-glycoside species during electrospray ionization and during collision-induced dissociation tandem mass spectrometry

Establishment of mass spectrometric fingerprints of novel synthetic cholesteryl neoglycolipids: The presence of a unique C-glycoside species during electrospray ionization and during collision-induced dissociation tandem mass spectrometry

Top-down identification and characterization of biomolecules by mass spectrometry

Stable isotopes in obesity research

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