RBEOER: a FORTRAN program for the computation of RBEs, OERs, survival ratios, and the effects of fractionation using the theory of dual radiation action

Zaider, Marco; Dicello, J.F.

doi:10.2172/6831213

Cited by 12 publications

(2 citation statements)

References 1 publication

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“…There are also issues related to dose-rate eects. These issues include the role of a sub-alpha re-sponse in the extrapolation of acute exposures to lowdose rates (Williams et al, 1999), adaptive responses (Sasaki, 1992), interphase cell death, G1 arrest, and the non-additivity of responses in mix-®eld irradiation (Cucinotta, 1999;Curtis, 1996;Virsik-Peuckert et al, 1997;Zaider and Dicello, 1978). Genetic factors in radiation responses also need to be considered (Virsik-Peuckert et al, 1997;Williams et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Analysis of MIR-18 results for physical and biological dosimetry: radiation shielding effectiveness in LEO

Cucinotta

Wilson

Williams

et al. 2000

Radiation Measurements

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We compare models of radiation transport and biological response to physical and biological dosimetry results from astronauts on the Mir space station. Transport models are shown to be in good agreement with physical measurements and indicate that the ratio of equivalent dose from the Galactic Cosmic Rays (GCR) to protons is about 3/2:1 and that this ratio will increase for exposures to internal organs. Two biological response models are used to compare to the Mir biodosimetry for chromosome aberration in lymphocyte cells; a track-structure model and the linear-quadratic model with linear energy transfer (LET) dependent weighting coefficients. These models are fit to in vitro data for aberration formation in human lymphocytes by photons and charged particles. Both models are found to be in reasonable agreement with data for aberrations in lymphocytes of Mir crew members: however there are differences between the use of LET dependent weighting factors and track structure models for assigning radiation quality factors. The major difference in the models is the increased effectiveness predicted by the track model for low charge and energy ions with LET near 10 keV/micrometers. The results of our calculations indicate that aluminum shielding, although providing important mitigation of the effects of trapped radiation, provides no protective effect from the galactic cosmic rays (GCR) in low-earth orbit (LEO) using either equivalent dose or the number of chromosome aberrations as a measure until about 100 g/cm 2 of material is used.

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Section: Discussionmentioning

confidence: 99%

Analysis of MIR-18 results for physical and biological dosimetry: radiation shielding effectiveness in LEO

Cucinotta

Wilson

Williams

et al. 2000

Radiation Measurements

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“…Within this framework expressions exist for various temporal patterns of dose delivery. If the dose rate is constant then (Lea and Catcheside 1942, Rossi and Kellerer 1973, Zaider and Dicello 1978)…”

Section: Single Fraction Protracted Exposurementioning

confidence: 99%

Tumour control probability: a formulation applicable to any temporal protocol of dose delivery

1999

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An analytic expression for the tumour control probability (TCP), valid for any temporal distribution of dose, is discussed. The TCP model, derived using the theory of birth-and-death stochastic processes, generalizes several results previously obtained. The TCP equation is [equation: see text] where S(t) is the survival probability at time t of the n clonogenic tumour cells initially present (at t = 0), and b and d are, respectively, the birth and death rates of these cells. Equivalently, b = 0.693/Tpot and d/b is the cell loss factor of the tumour. In this expression t refers to any time during or after the treatment; typically, one would take for t the end of the treatment period or the expected remaining life span of the patient. This model, which provides a comprehensive framework for predicting TCP, can be used predictively, or--when clinical data are available for one particular treatment modality (e.g. fractionated radiotherapy)--to obtain TCP-equivalent regimens for other modalities (e.g. low dose-rate treatments).

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The Relative Biological Effectiveness of Attenuated Protons

Robertson

Glisson

Archambeau

et al. 1993

Biological Effects and Physics of Solar and Galactic Cosmic Radiation Part B

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RBEOER: a FORTRAN program for the computation of RBEs, OERs, survival ratios, and the effects of fractionation using the theory of dual radiation action

Cited by 12 publications

References 1 publication

Analysis of MIR-18 results for physical and biological dosimetry: radiation shielding effectiveness in LEO

Analysis of MIR-18 results for physical and biological dosimetry: radiation shielding effectiveness in LEO

Tumour control probability: a formulation applicable to any temporal protocol of dose delivery

The Relative Biological Effectiveness of Attenuated Protons

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