2024
DOI: 10.21203/rs.3.rs-3842489/v1
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RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce EMT in lung cancer

Zhenlong Yu,
Wen Zhang,
Yulin Peng
et al.

Abstract: Metastasis serves as a malignant indicator and biological characteristic of pulmonary carcinoma. Epithelial-mesenchymal transition (EMT) plays a pivotal role in facilitating tumor invasion and metastasis, and enhances the aggressiveness of tumor cells. Prostaglandin E synthase 3 (PTGES3) functions as an HSP90 co-chaperone. Our previous study revealed its HSP90-independent role as a transcription factor involved in cancer-related inflammation. Our present study aims to investigate the impact and mechanism of p2… Show more

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