RBM24 suppresses cancer progression by upregulating miR-25 to target MALAT1 in nasopharyngeal carcinoma

Hua, Wen; Zhong, Qian; Xia, Tian; Chen, Qi; Zhang, Mei Yin; Zhou, Ai Jun; Tu, Zi Wei; Qu, Chen; Li, Man Zhi; Xia, Yun; Wang, Hui Yun; Xie, Dan; Claret, François X.; Song, Er Wei; Zeng, Mu‐Sheng

doi:10.1038/cddis.2016.252

Cited by 62 publications

(61 citation statements)

References 53 publications

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“…The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), also known as nuclear-enriched transcript 2 (NEAT2), is a lncRNA consisting of more than 8700 nt located on chromosome 11q13 and acts as a transcriptional regulator for various genes including those involved in cell proliferation, migration and metastasis. Several studies have shown that the aberrant expression of MALAT1 is found in various cancer types, and associated with clinical progression in human cancers including NPC [89-91]. LncRNA MALAT1 was highly expressed in 5-8F cells with a high metastatic potential compared to that in normal nasopharyngeal epithelium cells.…”

Section: Oncogenic Lncrnasmentioning

confidence: 99%

Functions and Roles of Long-Non-Coding RNAs in Human Nasopharyngeal Carcinoma

Hann²

2018

Cell Physiol Biochem

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Nasopharyngeal carcinoma (NPC) is one of the most common cancers originating in the nasopharynx and occurring at high frequency in South-eastern Asia and North Africa. Long non-coding RNAs (lncRNAs) are a class of non-protein-coding RNA molecules and key regulators of developmental, physiological, and pathological processes in humans. Emerging studies have shown that lncRNAs play critical roles in tumorgenicity and cancer prognosis. With the development of deep sequencing analyses, an extensive amount of functional lncRNAs have been discovered in nasopharyngeal carcinoma tissues and cell lines. However, the roles and mechanisms of aberrantly expressed lncRNAs in the pathogenesis of NPC are not fully understood. In this review, we briefly illustrate the concept, identification, functional characterization, and summarize recent advancements of biological functions of lncRNAs with heterogeneous mechanistic characterization and their involvement in NPC. Then, we describe individual lncRNAs that have been associated with tumorgenesis, growth, invasion, cancer stem cell differentiation, metastasis, drug resistance and discuss the strategies of their therapeutic manipulation in NPC. We also review the emerging insights into the role of lncRNAs and their potential as biomarkers and therapeutic targets for novel treatment paradigms. Finally, we highlight the up-to-date of clinical information involving lncRNAs and future directions in the linking lncRNAs to potential gene therapies, and how modifications of lncRNAs can be exploited for prevention and treatment of NPC.

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Section: Oncogenic Lncrnasmentioning

confidence: 99%

Functions and Roles of Long-Non-Coding RNAs in Human Nasopharyngeal Carcinoma

Hann²

2018

Cell Physiol Biochem

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“…Many lncRNAs, such as MALAT1, H19, and HOTAIR have been demonstrated as critical regulator of carcinogenesis and development of many cancers [8-12]. LncROR was first discovered in induced pluripotent stem cells (iPSCs).…”

Section: Introductionmentioning

confidence: 99%

LncROR Promotes Bladder Cancer Cell Proliferation, Migration, and Epithelial-Mesenchymal Transition

Chen

Peng

et al. 2017

Cell Physiol Biochem

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Background: LncRNA ROR, a tumor oncogene associated with various human cancers, has been reported to be involved in regulating various cellular processes, such as proliferation, apoptosis and invasion through targeting multiple genes. However, the molecular biological function in bladder cancer has not been clearly elucidated. The aim of this study is to explore ROR expression levels and evaluated its function in bladder cancer. Methods: LncRNA ROR expression levels in the 36 pairs of bladder cancer tissues (and corresponding non-tumor tissues) and bladder cancer cells were assessed by qRT-PCR. MTT assay, colony formation assay, flow cytometric analysis, wound healing assay, cell transwell assays, attachment/detachment and western blotting were performed to assess the effects of ROR on proliferation, apoptosis, migration/invasion and epithelial-to-mesenchymal (EMT) phenotypes in BC cells in vitro. ZEB1 is target of ROR. Rescue assays were performed to further confirm that ROR contributes to the progression of BC cells through targeting ZEB1. Results: LncRNA ROR was up-regulated in bladder cancer tissues (compared to adjacent non-tumor tissues) and was almost overexpression in bladder cancer cells (compared with normal urothelial cell line SVHUC-1 cells). Increased lncRNA ROR expression significantly promoted tumor cells proliferation, inhibited cells apoptosis, facilitated cells metastasis and contributed to the formation of EMT phenotype. While down-regulated ROR could obviously inhibit cells proliferation, promote cells apoptosis, inhibit metastasis and reverse EMT to MET. ZEB1 was a target gene of ROR and was positive correlation with the level of ROR in cancer tissues. Conclusion: These results indicated that lncRNA ROR was associated with tumor progression in bladder cancer cells.

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“…Previously, has‐miR‐615‐3p and MCM4 were identified to serve as new biomarkers for NPC via gene expression profiles GSE12452 (31 NPC and 10 normal samples) and GSE53819 (18 NPC and 18 normal samples), as well as miRNA expression profiles GSE32960 (312 NPC and 18 normal samples) and GSE36682 (62 NPC and six normal samples) obtained from the GEO database . Additionally, RBM24 is demonstrated to be a tumor suppressor in NPC after retrieval of the mRNA expression profiles from two data sets GSE12452 and GSE53819 . By contrast, in our study, the differentially expressed genes c9orf24, PCDP1, and LRRC46 related to NPC were retrieved in the data set GSE53819 were only comprised of 18 NPC and 18 normal samples.…”

Section: Discussionmentioning

confidence: 61%

“…44 Additionally, RBM24 is demonstrated to be a tumor suppressor in NPC after retrieval of the mRNA expression profiles from two data sets GSE12452 and GSE53819. 45 By contrast, in our study, the differentially expressed genes c9orf24, PCDP1, and LRRC46 related to NPC were retrieved in the data set GSE53819 were only comprised of 18 NPC and 18 normal samples. Therefore, c9orf24, PCDP1, and LRRC46 are not the only key genes related to NPC, and further studies are needed to compare the efficacy of these genes above.…”

Section: Degs Mebluementioning

confidence: 82%

Identification of Potential Therapeutic Gene Markers in Nasopharyngeal Carcinoma Based on Bioinformatics Analysis

Xue

Cao

Wang

et al. 2019

Clinical Translational Sci

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Nasopharyngeal carcinoma (NPC) is a common cancer found in the nasopharynx with high metastatic and invasive nature. Increasing evidences have identified the critical role of gene therapy in NPC treatment. Hence, this study was designed to identify specific gene markers that affected NPC progression through gene expression profile analysis. NPC‐related gene expression data set gene set enrichment (GSE)53819 were retrieved and analyzed to screen out differentially expressed genes (DEGs), followed by determination of their expression in noncancerous tissues and NPC specimens. Next, weighted gene co‐expression network analysis (WGCNA) was conducted on DEGs to obtain tumor‐associated gene modules. Genes in those modules were intersected with DEGs for gene ontology and Kyoto Encyclopedia of Genes and Genomes functional enrichment analysis. Then protein‐protein interaction network of tumor‐associated genes was constructed to select genes most closely linked to NPC. Afterward, expression of chromosome 9 open reading frame 24 (c9orf24), primary ciliary dyskinesia protein 1 (PCDP1), and leucine‐rich repeat‐containing protein 46 (LRRC46) was detected in GSE53819 and further verified in GSE12452 and GSE64634. Differential analysis on GSE53819 found that 2,173 genes were aberrantly expressed in NPC, among which 917 genes are upregulated and 1,256 genes are downregulated. WGCNA showed that genes were enriched in 17 modules and 727 genes exhibited ectopic expression in NPC and enriched in cytokine‐cytokine receptor interaction, cytochrome P450, and chemical carcinogenesis signaling pathways, among which c9orf24, PCDP1, and LRRC46 were poorly expressed in NPC. Therefore, c9orf24, PCDP1, and LRRC46 might serve as prominent diagnostic markers for NPC, which presents new insights for NPC therapy.

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RBM24 suppresses cancer progression by upregulating miR-25 to target MALAT1 in nasopharyngeal carcinoma

Cited by 62 publications

References 53 publications

Functions and Roles of Long-Non-Coding RNAs in Human Nasopharyngeal Carcinoma

Functions and Roles of Long-Non-Coding RNAs in Human Nasopharyngeal Carcinoma

LncROR Promotes Bladder Cancer Cell Proliferation, Migration, and Epithelial-Mesenchymal Transition

Identification of Potential Therapeutic Gene Markers in Nasopharyngeal Carcinoma Based on Bioinformatics Analysis

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