RCAN1 is a marker of oxidative stress, induced in acute pancreatitis

Norberg, K. Jessica; Nania, Salvatore; Li, Xuan; Gao, Hui; Szatmary, Peter; Segersvärd, Ralf; Haas, Stephan; Wagman, Annika; Arnelo, Urban; Heuchel, Rainer; Löhr, Matthias

doi:10.1016/j.pan.2018.08.005

Cited by 35 publications

(22 citation statements)

References 62 publications

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“…On the other hand, Sestrins may block oxidative damage-associated chemotherapy by reducing ROS (Budanov and Karin, 2008;Hagenbuchner et al, 2012). Sestrins were upregulated upon drug treatments in various type of pre-and mature-tumors as cell survival mechanism: head and neck cancers (Won et al, 2019), non-alcoholic steatohepatitis (Huang et al, 2020), HCC (Dai et al, 2018), osteosarcoma (Yen et al, 2018), acute pancreatitis (Norberg et al, 2018), colitis (Ro et al, 2016), bladder cancer (Hua et al, 2018), and prostate cancer (Fu et al, 2018;Shan et al, 2019). The distinctive roles of Sestrins as tumor suppressor or oncogene in the early or late stages of cancers need further investigation (Sanchez-Alvarez et al, 2019).…”

Section: Sestrins In Nutrient Stress-sensing and Metabolic Dysfunctionmentioning

confidence: 99%

SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health

Fay

Cyuzuzo

et al. 2020

Front. Cell Dev. Biol.

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Proper timely management of various external and internal stresses is critical for metabolic and redox homeostasis in mammals. In particular, dysregulation of mechanistic target of rapamycin complex (mTORC) triggered from metabolic stress and accumulation of reactive oxygen species (ROS) generated from environmental and genotoxic stress are well-known culprits leading to chronic metabolic disease conditions in humans. Sestrins are one of the metabolic and environmental stress-responsive groups of proteins, which solely have the ability to regulate both mTORC activity and ROS levels in cells, tissues and organs. While Sestrins are originally reported as one of several p53 target genes, recent studies have further delineated the roles of this group of stress-sensing proteins in the regulation of insulin sensitivity, glucose and fat metabolism, and redox-function in metabolic disease and aging. In this review, we discuss recent studies that investigated and manipulated Sestrins-mediated stress signaling pathways in metabolic and environmental health. Sestrins as an emerging dynamic group of stress-sensor proteins are drawing a spotlight as a preventive or therapeutic mechanism in both metabolic stress-associated pathologies and aging processes at the same time.

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Section: Sestrins In Nutrient Stress-sensing and Metabolic Dysfunctionmentioning

confidence: 99%

SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health

Fay

Cyuzuzo

et al. 2020

Front. Cell Dev. Biol.

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“…Alcohol is a major cause of acute and chronic pancreatitis in man, but little information is available on the molecular mechanisms that underly this pancreatic disease. Currently, the effects of alcohol have been largely studied on cell lines that exhibit features of acinar cells or on primary acinar cells isolated from rodents [92, 93]. However, these screens are labor intensive and largely limited by quantity of non-expanded primary tissue.…”

Section: Introductionmentioning

confidence: 99%

Organoids from the Human Fetal and Adult Pancreas

et al. 2019

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Purpose of ReviewNovel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue–derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine.Recent FindingsOrganoids derived from human fetal and adult pancreatic tissue have been used to study pancreas development and repair. Generated adult human pancreatic organoids harbor the capacity for clonal expansion and endocrine cell formation. In addition, organoids have been generated from human pancreatic ductal adenocarcinoma in order to study tumor behavior and assess drug responses.SummaryPancreatic organoids constitute an important translational bridge between in vitro and in vivo models, enhancing our understanding of pancreatic cell biology. Current applications for pancreatic organoid technology include studies on tissue regeneration, disease modelling, and drug screening.

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“…The following keywords were used: "acute pancreatitis" and "Mus musculus." The microarray datasets GSE109227, GSE3644 and GSE65146 were downloaded from the website (Table 1) [15][16][17] . The Affymetrix Mouse Expression 430A Array and Affymetrix Mouse Gene 1.0 ST Array were included in our study.…”

Section: Resultsmentioning

confidence: 99%

Acute Pancreatitis-Associated Genes Identified by Integrative Analysis of Gene Expression Data

Zeng

Zhu

Chen

2021

Preprint

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Background Acute pancreatitis (AP) is a common digestive disease. A better understanding of the biology and molecular pathogenesis of AP may provide the basis for the prevention and therapy of AP.Methods The gene expression datasets GSE109227, GSE3644 and GSE65146, which included gene expression profiles of pancreas samples from AP and control mice, were obtained from the Gene Expression Omnibus database. All differentially expressed genes (DEGs) were identified using GEO2R and annotated using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Results Thirty-eight DEGs were found to overlap among the three datasets. A protein-protein interaction (PPI) network was constructed; hub proteins were identified; and functional modules were extracted. Three genes (Cdh1, Iqgap1 and Actn4), which are involved in the adherens junction pathway, were identified using PPI analysis and may provide potential biomarkers for the diagnosis and treatment of AP.Conclusions We will further study the effects of the Cdh1, Iqgap1 and Actn4 genes on the occurrence and development of acute pancreatitis, which may provide new targets for the diagnosis and treatment of AP.

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RCAN1 is a marker of oxidative stress, induced in acute pancreatitis

Cited by 35 publications

References 62 publications

SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health

SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health

Organoids from the Human Fetal and Adult Pancreas

Acute Pancreatitis-Associated Genes Identified by Integrative Analysis of Gene Expression Data

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